Original Research


DOI :https://doi.org/10.18017/iuitfd.59478   IUP :https://doi.org/10.18017/iuitfd.59478    Full Text (PDF)

BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES

Ayşegül ÖzelEbru Alıcı DavutoğluNevin YılmazRıza Madazlı

Objective: The aim of this paper is to present 11 cases of patients diagnosed with breast cancer during pregnancy and their perinatal outcomes.

Material and methods: A retrospective analysis of 11 cases of breast cancer diagnosed during pregnancy between 2010-2015 was conducted in our clinic. In addition, the parents were surveyed regarding the health outcomes of the children exposed to chemotherapy and radiotherapy in utero.

Results: Mean maternal age was 33,7±4,7 , mean parity was 1,6±1,2 . All patients had invasive ductal carsinoma histopathologically. Mean gestational age during the diagnosis was 21,9±9,3 weeks . Any treatment had given for three patients (%27,3) during the pregnancy. Two patients operated (%22,2), one patient exposed only chemotherapy (%7,1), four patients operated and exposed adjuvant chemotherapy (%36,3), one patient operated and exposed radiotherapy (%7,1) during pregnancy. Mean gestational age at the delivery was 36,7±3,4 weeks and all neonates were appropriate for gestational age. The children exposed any kind of treatment in utero were normally without any significant exposured-related toxicity or health problems.

Conclusion: Pregnant women with breast cancer can be treated safely without concerns for serious complications or short-term health concerns for their offspring during the second and third trimesters.

DOI :https://doi.org/10.18017/iuitfd.59478   IUP :https://doi.org/10.18017/iuitfd.59478    Full Text (PDF)

GEBELİKTE TANI ALAN MEME KANSERİ:11 OLGUNUN OBSTETRİK VE PERİNATAL SONUÇLARI

Ayşegül ÖzelEbru Alıcı DavutoğluNevin YılmazRıza Madazlı

Amaç: Bu çalışmada amaç gebeliği sırasında meme kanseri tanısı almış 11 olgunun perinatal sonuçlarının sunulmasıdır.

Gereç ve yöntem: 2010-2015 yılları arasında kliniğimizde takip edilmiş, gebeliği sırasında meme kanseri tanısı alan 11 olgunun dosya verileri geriye dönük incelenmiştir. Ayrıca, intrauterin kemoterapi ve radyoterapiye maruz kalan çocukların ebeveynleri ile telefonla görüşülerek, güncel sağlık durumları ile ilgili bilgi edinilmiştir.

Bulgular: Hastaların tanı sırasındaki ortama yaşı 33,7±4,7, ortalama pariteleri 1,6±1,2 idi. Histopatolojik tip tüm hastalarda invaziv duktal karsinomdu. Tanı anındaki ortalama gebelik haftası 21,9±9,3 idi. Gebeliği sırasında üç hasta hiçbir tedavi almamıştı (%27,3). İki hasta opere edilmiş (%22,2), bir hastaya yalnızca kemoterapi verilmiş (%7,1), dört hastaya operasyon ve adjuvant kemoterapi uygulanmış (%36,3), bir hastaya da operasyon ve adjuvant radyoterapi verilmişti (%7,1). Doğum zamanında ortalama gestasyonel hafta 36,7±3,4 idi. Tüm yenidoğanların doğumdaki kilolarının gebelik haftalarına göre uygun olduğu görüldü. Gebeliği sırasında herhangi bir tedavi alan gebelerin çocuklarında tedaviye ilişkin olduğu düşünülen bir komplikasyona rastlanmadı.

Sonuç: Gebeliği sırasında meme kanseri tanısı alan kadınların gebelikleri sırasında tedavi edilmeleriyle gebelik ürünlerinin bu tedavilere intrauterin maruz kalmaları ciddi komplikasyon ve kısa dönem sağlık problemleri doğurmayabilir.


PDF View

References

  • 1.Loibl S, Han SN, von Minckwitz G,et al. Treatment of breast cancer during pregnancy: an observational study. Lancet Oncol 2012;13:887-96. google scholar
  • 2. Janni W, Hepp P, Nestle-Kraemling C, et al. Treatment of pregnancy –associated breast cancer. Expert Opin Pharmacother 2009;10:2259-67 google scholar
  • 3. Smith LH, Danielsen B, Allen ME, Cress R. Cancer associated with obstetric delivery: results of linkage with the California cancer registry. Am J Obstet Gynecol 2003;189:1128–35. google scholar
  • 4. Van Calsteren K, Heyns L, De Smet F, et al. Cancer during pregnancy: an analysis of 215 patients emphasizing the obstetrical and the neonatal outcomes. J Clin Oncol 2010;28:683–9. google scholar
  • 5. Ishida T, Yokoe T, Kasumi F, et al. Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation:analysis of case-control study in Japan. Jpn J Cancer Res 1992; 83:1143–9. google scholar
  • 6. Guinee VF, Olsson H, Moller T, et al. Effect of pregnancy on prognosis for young women with breast cancer. Lancet 1994;343:1587–9. google scholar
  • 7. Stensheim H, Moller B, van Dijk T, Fossa SD. Cause-specific survival for women diagnosed with cancer during pregnancy or lactation: a registrybased cohort study. J Clin Oncol 2009;27:45–51. google scholar
  • 8. Halaska MJ, Pentheroudakis G, Strnad P, et al. Presentation, management and outcome of 32 patients with pregnancy-associated breast cancer: a matched controlled study. Breast J 2009;15:461–7. google scholar
  • 9. Stensheim H, Moller B, van Dijk T et al. Causespecific survival for women diagnosed with cancer during pregnancy or lactation: A registry-based cohort study. J Clin Oncol 2009;27:45–51. google scholar
  • 10. Martin JA, Kochanek KD, Strobino DM et al. Annual summary of vital statistics–2003. Pediatrics 2005;115:619–34. google scholar
  • 11. Navrozoglou I, Vrekoussis T, Kontostolis E et al. Breast cancer during pregnancy: A mini-review. ESJO 2008;34: 837-43. google scholar
  • 12. Middleton LP, Amin M, Gwyn K, Theriault R, Sahin A. Breast carcinoma in pregnant women: assessment of clinicopathologic and immunohistochemical features. Cancer 2003;98:1055–60. google scholar
  • 13.Ring AE, Smith IE, Jones A, Shannon C, Galani E, Ellis PA. Chemotherapy for breast cancer during pregnancy: an 18-year experience from five London teaching hospitals. J Clin Oncol 2005;23:4192–7. google scholar
  • 14.Bonnier P, Romain S, Dilhuydy JM, et al. Infulence of pregnancy on the outcome of breast cancer: a case–control study. Societe Francaise de Senologie et de Pathologie Mammaire Study Group. Int J Cancer 1997;72:720–7. google scholar
  • 15.Ishida T, Yokoe T, Kasumi F, et al. Clinicopathologic characteristics and prognosis of breast cancer patients associated with pregnancy and lactation: analysis of case– control study in Japan. Jpn J Cancer Res 1992;83:1143–9. google scholar
  • 16. Litton JK and Theriault RL , et al. Breast cancer and pregnancy: current concepts in diagnosis and treatment. Oncologist 2010;15 (12)1238–47. google scholar
  • 17. Amant F, Deckers S, Van Calsteren K, et al. Breast cancer in pregnancy: Lancet 2012;379:570-79 . google scholar
  • 18. Lenhard MS, Bauerfeind I and Untch M. Breast cancer and pregnancy: challenges of chemotherapy. Crit Rev Oncol Hematol 2008; 67: 196–203. google scholar
  • 19. Hahn KM, Johnson PH, Gordon N, Kuerer H, Middleton L, Ramirez M, Yang W, Perkins G, Hortobagyi, Theriault RL: Treatment of pregnant breast cancer patients and outcomes of children exposed to chemotherapy in utero. Cancer 2006;107:1219–26. google scholar
  • 20. Avíles A, Neri N: Hematological malignancies and pregnancy: a final report of 84 children who received chemotherapy in utero. Clin Lymphoma 2001;2:173–7. google scholar
  • 21. Henk B. K, Henk S: Radiotherapy during pregnancy: fact and fiction. Lancet Oncol 2005;6:328-33. google scholar
  • 22. Van der Giessen PH. Measurement of the peripheral dose for the tangential breast treatment technique with Co-60 gamma radiation and high energy Xrays. Radiother Oncol 1997;42:257–64. google scholar
  • 23. Ngu SL, Duval P, Collins C. Foetal radiation dose in radiotherapy for breast cancer. Australas Radiol 1992;36:321–2. google scholar
  • 24. Antypas C, Sandilos P, Kouvaris J, et al. Fetal dose evaluation during breast cancer radiotherapy. Int J Radiat Oncol Biol Phys 1998;40:995–9. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Özel, A., Alıcı Davutoğlu, E., Yılmaz, N., & Madazlı, R. (0001). BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES. Journal of Istanbul Faculty of Medicine, 79(2), 61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478


AMA

Özel A, Alıcı Davutoğlu E, Yılmaz N, Madazlı R. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES. Journal of Istanbul Faculty of Medicine. 0001;79(2):61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478


ABNT

Özel, A.; Alıcı Davutoğlu, E.; Yılmaz, N.; Madazlı, R. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 79, n. 2, p. 61-65, 0001.


Chicago: Author-Date Style

Özel, Ayşegül, and Ebru Alıcı Davutoğlu and Nevin Yılmaz and Rıza Madazlı. 0001. “BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES.” Journal of Istanbul Faculty of Medicine 79, no. 2: 61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478


Chicago: Humanities Style

Özel, Ayşegül, and Ebru Alıcı Davutoğlu and Nevin Yılmaz and Rıza Madazlı. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES.” Journal of Istanbul Faculty of Medicine 79, no. 2 (Oct. 2024): 61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478


Harvard: Australian Style

Özel, A & Alıcı Davutoğlu, E & Yılmaz, N & Madazlı, R 0001, 'BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES', Journal of Istanbul Faculty of Medicine, vol. 79, no. 2, pp. 61-65, viewed 13 Oct. 2024, https://doi.org/https://doi.org/10.18017/iuitfd.59478


Harvard: Author-Date Style

Özel, A. and Alıcı Davutoğlu, E. and Yılmaz, N. and Madazlı, R. (0001) ‘BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES’, Journal of Istanbul Faculty of Medicine, 79(2), pp. 61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478 (13 Oct. 2024).


MLA

Özel, Ayşegül, and Ebru Alıcı Davutoğlu and Nevin Yılmaz and Rıza Madazlı. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES.” Journal of Istanbul Faculty of Medicine, vol. 79, no. 2, 0001, pp. 61-65. [Database Container], https://doi.org/https://doi.org/10.18017/iuitfd.59478


Vancouver

Özel A, Alıcı Davutoğlu E, Yılmaz N, Madazlı R. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES. Journal of Istanbul Faculty of Medicine [Internet]. 13 Oct. 2024 [cited 13 Oct. 2024];79(2):61-65. Available from: https://doi.org/https://doi.org/10.18017/iuitfd.59478 doi: https://doi.org/10.18017/iuitfd.59478


ISNAD

Özel, Ayşegül - Alıcı Davutoğlu, Ebru - Yılmaz, Nevin - Madazlı, Rıza. BREAST CANCER DURING PREGNANCY: THE OBSTETRIC AND PERINATAL OUTCOMES OF 11 CASES”. Journal of Istanbul Faculty of Medicine 79/2 (Oct. 2024): 61-65. https://doi.org/https://doi.org/10.18017/iuitfd.59478



Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.