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Case Report


DOI :10.26650/IUITFD.2019.0098   IUP :10.26650/IUITFD.2019.0098    Full Text (PDF)

CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION

Ayşe Süleyman, Esra Özek Yücel, Sevgi Sipahi Çimen, Zeynep Hızlı Demirkale, Cevdet Özdemir, Zeynep Tamay, Nermin Güler

Clarithromycin and azithromycin are the most frequently prescribed oral macrolide antibiotics for children. Macrolides are relatively safe antibiotics due to their low allergenicity, but are nevertheless known to cause hypersensitivity reactions. Azithromycin appears to be responsible for severe reactions more often than clarithromycin. The most common reactions are maculopapular exanthems, and macrolide-induced anaphylaxis is exceptionally rare. Skin tests are not enough for the diagnosis of macrolide allergies, and oral provocation tests are necessary for a definite diagnosis. Here, we present a case of anaphylaxis during oral provocation with azithromycin, in which intolerance to amoxicillin-clavulanic acid and clarithromycin have been verified by provocation testing previously.

Keywords: Anaphylaxis, azithromycin, drug allergy, drug provocation test
DOI :10.26650/IUITFD.2019.0098   IUP :10.26650/IUITFD.2019.0098    Full Text (PDF)

OLGU SUNUMU: AZİTROMİSİN PROVOKASYONU ESNASINDA ANAFİLAKSİ

Ayşe Süleyman, Esra Özek Yücel, Sevgi Sipahi Çimen, Zeynep Hızlı Demirkale, Cevdet Özdemir, Zeynep Tamay, Nermin Güler

Klaritromisin ve azitromisin çocuklarda sık kullanılan oral makrolid antibiyotiklerdir. Makrolidler düşük alerjenitelerinden dolayı nispeten güvenli antibiyotiklerdir yine de hipersensitivite reaksiyonlarına neden olabilecekleri bilinmektedir. Azitromisin, klaritromisine kıyasla daha ağır reaksiyonlar yapabilmektedir. En sık reaksiyon makülopapüler döküntüdür ve makrolidlerle ilişkili anafilaksi son derece nadirdir. Bugüne kadar az sayıda makrolidlerle ilişkili anafilaksi olgusu bildirilmiştir. Makrolid alerjilerinin tanısı için deri testleri yeterli değildir ve kesin tanı için oral provokasyon testi yapılması gerekmektedir. Burada amoksisilin-klavulanik asit ve klaritromisini tolere edemediği provokasyon testi ile gösterilmiş ve oral azitromisin provokasyon testi sırasında anafilaksi gelişen bir vakayı sunduk. 

Keywords: Anafilaksi, azitromisin, ilaç alerjisi, ilaç provokasyon testi

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Citations

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APA

Süleyman, A., Özek Yücel, E., Sipahi Çimen, S., Hızlı Demirkale, Z., Özdemir, C., Tamay, Z., & Güler, N. (2021). CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION. Journal of Istanbul Faculty of Medicine, 84(2), 278-280. https://doi.org/10.26650/IUITFD.2019.0098


AMA

Süleyman A, Özek Yücel E, Sipahi Çimen S, Hızlı Demirkale Z, Özdemir C, Tamay Z, Güler N. CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION. Journal of Istanbul Faculty of Medicine. 2021;84(2):278-280. https://doi.org/10.26650/IUITFD.2019.0098


ABNT

Süleyman, A.; Özek Yücel, E.; Sipahi Çimen, S.; Hızlı Demirkale, Z.; Özdemir, C.; Tamay, Z.; Güler, N. CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 84, n. 2, p. 278-280, 2021.


Chicago: Author-Date Style

Süleyman, Ayşe, and Esra Özek Yücel and Sevgi Sipahi Çimen and Zeynep Hızlı Demirkale and Cevdet Özdemir and Zeynep Tamay and Nermin Güler. 2021. “CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION.” Journal of Istanbul Faculty of Medicine 84, no. 2: 278-280. https://doi.org/10.26650/IUITFD.2019.0098


Chicago: Humanities Style

Süleyman, Ayşe, and Esra Özek Yücel and Sevgi Sipahi Çimen and Zeynep Hızlı Demirkale and Cevdet Özdemir and Zeynep Tamay and Nermin Güler. “CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION.” Journal of Istanbul Faculty of Medicine 84, no. 2 (Apr. 2024): 278-280. https://doi.org/10.26650/IUITFD.2019.0098


Harvard: Australian Style

Süleyman, A & Özek Yücel, E & Sipahi Çimen, S & Hızlı Demirkale, Z & Özdemir, C & Tamay, Z & Güler, N 2021, 'CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION', Journal of Istanbul Faculty of Medicine, vol. 84, no. 2, pp. 278-280, viewed 30 Apr. 2024, https://doi.org/10.26650/IUITFD.2019.0098


Harvard: Author-Date Style

Süleyman, A. and Özek Yücel, E. and Sipahi Çimen, S. and Hızlı Demirkale, Z. and Özdemir, C. and Tamay, Z. and Güler, N. (2021) ‘CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION’, Journal of Istanbul Faculty of Medicine, 84(2), pp. 278-280. https://doi.org/10.26650/IUITFD.2019.0098 (30 Apr. 2024).


MLA

Süleyman, Ayşe, and Esra Özek Yücel and Sevgi Sipahi Çimen and Zeynep Hızlı Demirkale and Cevdet Özdemir and Zeynep Tamay and Nermin Güler. “CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION.” Journal of Istanbul Faculty of Medicine, vol. 84, no. 2, 2021, pp. 278-280. [Database Container], https://doi.org/10.26650/IUITFD.2019.0098


Vancouver

Süleyman A, Özek Yücel E, Sipahi Çimen S, Hızlı Demirkale Z, Özdemir C, Tamay Z, Güler N. CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION. Journal of Istanbul Faculty of Medicine [Internet]. 30 Apr. 2024 [cited 30 Apr. 2024];84(2):278-280. Available from: https://doi.org/10.26650/IUITFD.2019.0098 doi: 10.26650/IUITFD.2019.0098


ISNAD

Süleyman, Ayşe - Özek Yücel, Esra - Sipahi Çimen, Sevgi - Hızlı Demirkale, Zeynep - Özdemir, Cevdet - Tamay, Zeynep - Güler, Nermin. “CASE REPORT: ANAPHYLAXIS DURING AZITHROMYCIN PROVOCATION”. Journal of Istanbul Faculty of Medicine 84/2 (Apr. 2024): 278-280. https://doi.org/10.26650/IUITFD.2019.0098



TIMELINE


Submitted09.12.2019
Accepted25.04.2020
Published Online04.03.2021

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