POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG  RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL  PROPAGATION PATTERNS IN SCALP EEG

Şirin İnan Nermin; Samancı Bedia; Yılmaz Ebru; Gökyiğit Ayşen; Baykan Betül; Gürses Rabia; Bebek Nerses

doi:https://dx.doi.org/10.26650/IUITFD.2020.0053

Research Article

DOI :10.26650/IUITFD.2020.0053 IUP :10.26650/IUITFD.2020.0053 Full Text (PDF)

POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG

Nermin Görkem Şirin İnan, Bedia Samancı, Ebru Yılmaz, Ayşen Zehra Gökyiğit, Betül Baykan, Rabia Candan Gürses, Nerses Bebek

Objective: In presurgical evaluation, positron emission tomography with fluorodeoxyglucose-F18 (FDG-PET) is an important tool in identifying epileptogenic area. The aim of this study was to evaluate glucose metabolism in FDG-PET in patients with temporal lobe epilepsy (TLE) showing ‘switch-of lateralisation’ (SL) and ‘bilateral asynchrony’ (BA) in ictal scalp EEG and compare their results with patients with TLE and none of these patterns. Methods: Twenty-four patients with TLE showing SL and/or BA in at least one of their seizures in video-EEG monitoring and 38 patients with TLE and without these patterns who had epilepsy surgery and a follow-up at least 5-years were included. The clinical, electrophysiological and imaging features were evaluated and a statistical comparison was performed between the groups. Results: Bilateral hypometabolism was more frequent in patients with SL and/or BA (39%) than in patients without these patterns (0%, p=0.040) in parallel with bilateral interictal epileptiform discharges and bilateral abnormalities in MRI. The presence of unilateral or bilateral hypometabolism was not related to postsurgical outcome in patients with SL and/or BA. Conclusion: The possibility of low accuracy in the lateralisation of hypometabolism in FDG-PET might be interpreted cautiously in TLE with bilateral independent ictal activity like SL and BA.

Keywords: Temporal lobe epilepsy, ictal propagation patterns, switch-of lateralisation, bilateral asynchrony, FDG-PET, functional imaging

DOI :10.26650/IUITFD.2020.0053 IUP :10.26650/IUITFD.2020.0053 Full Text (PDF)

YÜZEYEL EEG’DE FARKLI İKTAL YAYILIM PATERNLERİ GÖSTEREN İLACA DİRENÇLİ TEMPORAL LOB EPİLEPSİLİ HASTALARDA POZİTRON EMİSYON TOMOGRAFİ

Nermin Görkem Şirin İnan, Bedia Samancı, Ebru Yılmaz, Ayşen Zehra Gökyiğit, Betül Baykan, Rabia Candan Gürses, Nerses Bebek

Amaç: Temporal lob epilepsili (TLE) hastaların cerrahi öncesi değerlendirilmesinde epileptojenik alanın belirlenmesi amacıyla yapılan flurodeoksiglukoz F 18’li positron emisyon tomografisi (FDG-PET) incelemesi önemli bilgiler sağlamaktadır. Bu çalışmada, yüzeyel iktal EEG kayıtlarında ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarının interiktal FDG-PET incelemelerinde glukoz metabolizma verilerinin incelenmesi ve bu paternlerin izlenmediği TLE hastaları ile karşılaştırılması amaçlandı. Gereç ve Yöntem: Video-EEG monitörizasyon (VEM) incelemesinde en az bir nöbetinde ‘switch-of lateralizasyon’ ve ‘bilateral asenkroni’ saptanan yirmi dört TLE’li hasta çalışmaya dahil edildi. Kontrol grubu olarak, bu iktal paternlerin izlenmediği, epilepsi cerrahisi geçirmiş ve 5 yıllık izlemi olan TLE hastaları belirlendi. Klinik, elektrofizyolojik ve görüntüleme bulguları değerlendirildi ve hasta grupları arasında istatistiksel olarak kıyaslandı. Bulgular: VEM’de ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarda (%39), bu paternlerin izlenmediği gruba kıyasla (%0) FDG-PET incelemelerinde bilateral temporal hipometabolizma görülme oranı daha fazlaydı (p=0.040). Bu oran, bilateral interiktal epileptiform aktivite ve bilateral manyetik rezonans görüntülme anomalileri için de benzerdi. Opere olmuş ve VEM incelemelerinde ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalar içerisinde FDG-PET’de bilateral temporal hipometabolizma varlığı, cerrahi sonrası sonlanım açısından farklılık göstermemekteydi.

Sonuç: Sonuçlarımız, cerrahi öncesi değerlendirmede VEM’de ‘switch-of lateralizasyon’ ve/veya ‘bilateral asenkroni’ izlenen TLE’li hastalarda FDG-PET bulgularının lateralizasyon değerlerinin dikkatli yorumlanması gerektiğini göstermiştir.

Keywords: Temporal lob epilepsisi, iktal yayılım paternleri, switch-of lateralizasyon, bilateral asenkroni, FDG-PET, fonksiyonel görüntüleme

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APA

Şirin İnan, N.G., Samancı, B., Yılmaz, E., Gökyiğit, A.Z., Baykan, B., Gürses, R.C., & Bebek, N. (2021). POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. Journal of Istanbul Faculty of Medicine, 84(2), 175-180. https://doi.org/10.26650/IUITFD.2020.0053

AMA

Şirin İnan N G, Samancı B, Yılmaz E, Gökyiğit A Z, Baykan B, Gürses R C, Bebek N. POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. Journal of Istanbul Faculty of Medicine. 2021;84(2):175-180. https://doi.org/10.26650/IUITFD.2020.0053

ABNT

Şirin İnan, N.G.; Samancı, B.; Yılmaz, E.; Gökyiğit, A.Z.; Baykan, B.; Gürses, R.C.; Bebek, N. POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 84, n. 2, p. 175-180, 2021.

Chicago: Author-Date Style

Şirin İnan, Nermin Görkem, and Bedia Samancı and Ebru Yılmaz and Ayşen Zehra Gökyiğit and Betül Baykan and Rabia Candan Gürses and Nerses Bebek. 2021. “POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG.” Journal of Istanbul Faculty of Medicine 84, no. 2: 175-180. https://doi.org/10.26650/IUITFD.2020.0053

Chicago: Humanities Style

Şirin İnan, Nermin Görkem, and Bedia Samancı and Ebru Yılmaz and Ayşen Zehra Gökyiğit and Betül Baykan and Rabia Candan Gürses and Nerses Bebek. “POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG.” Journal of Istanbul Faculty of Medicine 84, no. 2 (May. 2024): 175-180. https://doi.org/10.26650/IUITFD.2020.0053

Harvard: Australian Style

Şirin İnan, NG & Samancı, B & Yılmaz, E & Gökyiğit, AZ & Baykan, B & Gürses, RC & Bebek, N 2021, 'POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG', Journal of Istanbul Faculty of Medicine, vol. 84, no. 2, pp. 175-180, viewed 17 May. 2024, https://doi.org/10.26650/IUITFD.2020.0053

Harvard: Author-Date Style

Şirin İnan, N.G. and Samancı, B. and Yılmaz, E. and Gökyiğit, A.Z. and Baykan, B. and Gürses, R.C. and Bebek, N. (2021) ‘POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG’, Journal of Istanbul Faculty of Medicine, 84(2), pp. 175-180. https://doi.org/10.26650/IUITFD.2020.0053 (17 May. 2024).

MLA

Şirin İnan, Nermin Görkem, and Bedia Samancı and Ebru Yılmaz and Ayşen Zehra Gökyiğit and Betül Baykan and Rabia Candan Gürses and Nerses Bebek. “POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG.” Journal of Istanbul Faculty of Medicine, vol. 84, no. 2, 2021, pp. 175-180. [Database Container], https://doi.org/10.26650/IUITFD.2020.0053

Vancouver

Şirin İnan NG, Samancı B, Yılmaz E, Gökyiğit AZ, Baykan B, Gürses RC, Bebek N. POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG. Journal of Istanbul Faculty of Medicine [Internet]. 17 May. 2024 [cited 17 May. 2024];84(2):175-180. Available from: https://doi.org/10.26650/IUITFD.2020.0053 doi: 10.26650/IUITFD.2020.0053

ISNAD

Şirin İnan, NerminGörkem - Samancı, Bedia - Yılmaz, Ebru - Gökyiğit, AyşenZehra - Baykan, Betül - Gürses, RabiaCandan - Bebek, Nerses. “POSITRON EMISSION TOMOGRAPHY IN PATIENTS WITH DRUG RESISTANT TEMPORAL LOBE EPILEPSY WITH DIFFERENT ICTAL PROPAGATION PATTERNS IN SCALP EEG”. Journal of Istanbul Faculty of Medicine 84/2 (May. 2024): 175-180. https://doi.org/10.26650/IUITFD.2020.0053

Volume 84, Issue 22021, P. 175-180

TIMELINE

Submitted	10.05.2020
Accepted	10.05.2020
Published Online	23.03.2021

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