THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF  INFLAMMATORY BOWEL DISEASES

Kutlu Yasin; Toprak İlkim; Gökden Yasemin; Eruzun Hasan; Arman Yücel; Aydın Yoldemir Şengül; Toprak Zeki; Tükek Tufan

doi:https://dx.doi.org/10.26650/IUITFD.2020.0090

Research Article

DOI :10.26650/IUITFD.2020.0090 IUP :10.26650/IUITFD.2020.0090 Full Text (PDF)

THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES

Yasin Kutlu, İlkim Deniz Toprak, Yasemin Gökden, Hasan Eruzun, Yücel Arman, Şengül Aydın Yoldemir, Zeki Toprak, Tufan Tükek

Objective: In inflammatory bowel disease (IBD), there is no reliable biomarker, yet. We aimed to determine whether Serum Soluble Triggering Receptor Expressed on Myeloid Cells-1 (sTREM-1) could be useful as a marker for the diagnosis and/or the determination of disease activity in patients with IBD. Material and Method: A total of 47 patients with ulcerative colitis (UC) and 25 patients with Crohn’s disease (CD) were prospectively enrolled. Clinical disease activity was analyzed using the Crohn’s Disease Activity Index (CDAI) for CD and the Truelove-Witts index for UC. Results: sTREM-1 levels were significantly lower in patients with IBD compared to healthy controls (p=0.001). In comparison of the levels of sTREM-1 between the different groups (CD, UC, and healthy controls) the difference was statistically significant. No considerable differences in sTREM-1 levels were determined in patients with active versus quiescent disease. The sTREM-1 levels negatively correlated with C-reactive protein, blood neutrophil-lymphocyte ratio, and positively with haemoglobin levels. Conclusion: sTREM-1 levels are decreased in IBD patients compared with the healthy individuals. It may, therefore, be useful for the diagnosis of IBD. However, it does not seem to be a precise marker of disease activity in IBD and cannot be suggested for assessing disease activity in these patients.

Keywords: sTREM-1, inflammatory bowel diseases, Crohn’s disease, ulcerative colitis

DOI :10.26650/IUITFD.2020.0090 IUP :10.26650/IUITFD.2020.0090 Full Text (PDF)

İNFLAMATUAR BARSAK HASTALIKLARI AKTİVASYONU İLE sTREM-1 ARASINDAKİ İLİŞKİ

Yasin Kutlu, İlkim Deniz Toprak, Yasemin Gökden, Hasan Eruzun, Yücel Arman, Şengül Aydın Yoldemir, Zeki Toprak, Tufan Tükek

Amaç: İnflamatuar barsak hastalıkları (İBS) tanısında henüz uygun bir biyobelirteç bulunmamıştır. Çalışmamızda STREM-1 molekülünün bir belirteç olarak, İBS tanısında ve hastalık aktivitesini belirlemede uygunluğunu belirlemeyi amaçladık. Gereç ve Yöntem: Toplam 47 ülseratif kolit ve 25 Crohn hastalığı tanılı vaka çalışmaya dahil edildi. Crohn hastalığı için aktiviteyi belirlemede Crohn Hastalığı Aktivite İndeksi (CDAI), ülseratif kolit için ise Truelove-Witts indeksi kullanıldı. Bulgular: Sağlıklı grupla kıyaslandığında, sTREM-1 molekülü, İBS hastalarında anlamlı derecede düşük saptandı. Ülseratif kolit, Crohn hastalığı ve sağlıklı grup arasında sTREM-1 molekülü kıyaslandığında ise fark istatiksel olarak anlamlıydı. Aktif ve remisyonda olan hastalarda sTREM-1 düzeylerinde önemli bir fark bulunmamıştır. sTREM-1 seviyeleri C-reaktif protein, nötrofil-lenfosit oranı ve hemoglobin düzeyleri ile negatif korelasyon gösterdi. Sonuç: sTREM-1 seviyeleri İBS’de sağlıklı bireylere göre daha düşüktür. İBS tanısı için yararlı olabilir. Ancak, İBS’de hastalık aktivitesinin belirlemede doğru bir belirteç gibi görünmemektedir ve bu hastalarda hastalığın aktivitesini değerlendirmek için önerilemez.

Keywords: sTREM-1, inflamatuar barsak hastalıkları, crohn hastalığı, ülseratif kolit

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APA

Kutlu, Y., Toprak, İ.D., Gökden, Y., Eruzun, H., Arman, Y., Aydın Yoldemir, Ş., Toprak, Z., & Tükek, T. (2021). THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES. Journal of Istanbul Faculty of Medicine, 84(3), 318-323. https://doi.org/10.26650/IUITFD.2020.0090

AMA

Kutlu Y, Toprak İ D, Gökden Y, Eruzun H, Arman Y, Aydın Yoldemir Ş, Toprak Z, Tükek T. THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES. Journal of Istanbul Faculty of Medicine. 2021;84(3):318-323. https://doi.org/10.26650/IUITFD.2020.0090

ABNT

Kutlu, Y.; Toprak, İ.D.; Gökden, Y.; Eruzun, H.; Arman, Y.; Aydın Yoldemir, Ş.; Toprak, Z.; Tükek, T. THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 84, n. 3, p. 318-323, 2021.

Chicago: Author-Date Style

Kutlu, Yasin, and İlkim Deniz Toprak and Yasemin Gökden and Hasan Eruzun and Yücel Arman and Şengül Aydın Yoldemir and Zeki Toprak and Tufan Tükek. 2021. “THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES.” Journal of Istanbul Faculty of Medicine 84, no. 3: 318-323. https://doi.org/10.26650/IUITFD.2020.0090

Chicago: Humanities Style

Kutlu, Yasin, and İlkim Deniz Toprak and Yasemin Gökden and Hasan Eruzun and Yücel Arman and Şengül Aydın Yoldemir and Zeki Toprak and Tufan Tükek. “THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES.” Journal of Istanbul Faculty of Medicine 84, no. 3 (Dec. 2024): 318-323. https://doi.org/10.26650/IUITFD.2020.0090

Harvard: Australian Style

Kutlu, Y & Toprak, İD & Gökden, Y & Eruzun, H & Arman, Y & Aydın Yoldemir, Ş & Toprak, Z & Tükek, T 2021, 'THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES', Journal of Istanbul Faculty of Medicine, vol. 84, no. 3, pp. 318-323, viewed 23 Dec. 2024, https://doi.org/10.26650/IUITFD.2020.0090

Harvard: Author-Date Style

Kutlu, Y. and Toprak, İ.D. and Gökden, Y. and Eruzun, H. and Arman, Y. and Aydın Yoldemir, Ş. and Toprak, Z. and Tükek, T. (2021) ‘THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES’, Journal of Istanbul Faculty of Medicine, 84(3), pp. 318-323. https://doi.org/10.26650/IUITFD.2020.0090 (23 Dec. 2024).

MLA

Kutlu, Yasin, and İlkim Deniz Toprak and Yasemin Gökden and Hasan Eruzun and Yücel Arman and Şengül Aydın Yoldemir and Zeki Toprak and Tufan Tükek. “THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES.” Journal of Istanbul Faculty of Medicine, vol. 84, no. 3, 2021, pp. 318-323. [Database Container], https://doi.org/10.26650/IUITFD.2020.0090

Vancouver

Kutlu Y, Toprak İD, Gökden Y, Eruzun H, Arman Y, Aydın Yoldemir Ş, Toprak Z, Tükek T. THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES. Journal of Istanbul Faculty of Medicine [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];84(3):318-323. Available from: https://doi.org/10.26650/IUITFD.2020.0090 doi: 10.26650/IUITFD.2020.0090

ISNAD

Kutlu, Yasin - Toprak, İlkimDeniz - Gökden, Yasemin - Eruzun, Hasan - Arman, Yücel - Aydın Yoldemir, Şengül - Toprak, Zeki - Tükek, Tufan. “THE RELATIONSHIP BETWEEN sTREM-1 AND ACTIVATION OF INFLAMMATORY BOWEL DISEASES”. Journal of Istanbul Faculty of Medicine 84/3 (Dec. 2024): 318-323. https://doi.org/10.26650/IUITFD.2020.0090

Volume 84, Issue 32021, P. 318-323

TIMELINE

Submitted	15.07.2020
Accepted	01.11.2020
Published Online	05.07.2021

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