THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN  EVALUATING THE RESPONSE TO STEROID THERAPY IN  IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS

Rona Günay; Arifoğlu Meral; Kadıoğlu Voyvoda Şadiye; Çetin Kenan; Damgacı Lale

doi:https://dx.doi.org/10.26650/IUITFD.1125446

Research Article

DOI :10.26650/IUITFD.1125446 IUP :10.26650/IUITFD.1125446 Full Text (PDF)

THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS

Günay Rona, Meral Arifoğlu, Şadiye Nuray Kadıoğlu Voyvoda, Kenan Çetin, Lale Damgacı

Objective: The aim of this study was to investigate the role of diffusion-weighted magnetic resonance imaging (DW MRI) with an apparent diffusion coefficient (ADC) map in evaluating the response to treatment of steroid-treated idiopathic granulomatous mastitis (IGM) lesions. Materials and Methods: This retrospective study included 99 lesions of 58 female patients (average age: 32.91 years; range: 22–55 years) with biopsy-proven IGM. Patients were treated with oral and topical steroids. All pre-treatment and post-treatment MR examinations were evaluated. The maximal size of the masses and nonmass enhancement (NME) lesions were measured. Patients were classified as complete response (CR), partial response (PR), and non-response (NR) according to the dynamic contrast-enhanced (DCE) MR findings after treatment. Results: ADC values of areas occupied by IGM (0.933±0.317x10-3 mm2 /sec) were lower than contralateral normal parenchyma (1.259±0.423x10-3 mm2 /sec). Twenty-two (22.22%) of the lesions were in the NR group, 30 (30.30%) in the PR group, and 47 (47.47%) in the CR group. There was no significant difference between the pre-treatment ADC values in NR, PR, and CR groups (p=0.228). There was a significant difference between the pre-treatment and post-treatment ADC values in the PR groups (p=0.001). Conclusion: DW MR imaging in IGM is a useful method to monitor the response to treatment. However, it is not successful in predicting response to treatment.

Keywords: Granulomatous Mastitis, Magnetic Resonance Imaging, Diffusion-Weighted MRI, Treatment Response, Steroid Therapy

DOI :10.26650/IUITFD.1125446 IUP :10.26650/IUITFD.1125446 Full Text (PDF)

İDİYOPATİK GRANÜLOMATÖZ MASTİT LEZYONLARINDA STEROİD TEDAVİSİNE YANITIN DEĞERLENDİRİLMESİNDE DİFÜZYON AĞIRLIKLI MR GÖRÜNTÜLEMENİN ROLÜ

Günay Rona, Meral Arifoğlu, Şadiye Nuray Kadıoğlu Voyvoda, Kenan Çetin, Lale Damgacı

Amaç: Bu çalışmanın amacı, idiyopatik granülomatöz mastit (İGM) lezyonlarının steroit tedavisine yanıtını değerlendirmede, görünür bir difüzyon katsayısı (ADC) haritası ile difüzyon ağırlıklı manyetik rezonans görüntülemenin (DW MRG) rolünü araştırmaktı. Gereç ve Yöntem: Bu retrospektif çalışma, biyopsi ile kanıtlanmış İGM’li 58 kadın (ortalama yaş 32,91 yıl, aralık=22-55 yıl) hastanın 99 lezyonunu içeriyordu. Hastalar oral ve topikal steroidlerle tedavi edildi. Tüm tedavi öncesi ve tedavi sonrası MR incelemeleri değerlendirildi. Kitlelerin ve kitlesel olmayan kontrastlanmaların maksimum boyutu ölçüldü. Tedavi sonrası dinamik kontrastlı (DK) MR bulgularına göre hastalar tam yanıt, kısmi yanıt ve yanıtsız olarak sınıflandırıldı. Bulgular: İGM (0,933±0,317x10-3 mm2 /sn) tarafından işgal edilen alanların ADC değerleri, kontralateral normal parankimden (1,259±0,423x10-3 mm2 /sn) daha düşüktü. Lezyonların 22’si (%22,22) yanıtsız, 30’u (%30,30) kısmi yanıt ve 47’si tam yanıt (%47,47) grubundaydı. Üç tedavi grubunda tedavi öncesi ADC değerleri arasında anlamlı bir fark yoktu (p=0,228). Kısmi yanıt grubunda tedavi öncesi ve tedavi sonrası ADC değerleri arasında anlamlı fark vardı (p=0,001). Sonuç: İGM’de DW MR görüntüleme, tedaviye yanıtı izlemek için yararlı bir yöntemdir. Ancak tedaviye yanıtı tahmin etmede başarılı değildir.

Keywords: Granülomatöz mastitis, Manyetik rezonans görüntüleme, Difüzyon ağırlıklı MRG, Tedavi yanıtı, Steroid tedavisi

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APA

Rona, G., Arifoğlu, M., Kadıoğlu Voyvoda, Ş.N., Çetin, K., & Damgacı, L. (2022). THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS. Journal of Istanbul Faculty of Medicine, 85(4), 456-461. https://doi.org/10.26650/IUITFD.1125446

AMA

Rona G, Arifoğlu M, Kadıoğlu Voyvoda Ş N, Çetin K, Damgacı L. THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS. Journal of Istanbul Faculty of Medicine. 2022;85(4):456-461. https://doi.org/10.26650/IUITFD.1125446

ABNT

Rona, G.; Arifoğlu, M.; Kadıoğlu Voyvoda, Ş.N.; Çetin, K.; Damgacı, L. THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS. Journal of Istanbul Faculty of Medicine, [Publisher Location], v. 85, n. 4, p. 456-461, 2022.

Chicago: Author-Date Style

Rona, Günay, and Meral Arifoğlu and Şadiye Nuray Kadıoğlu Voyvoda and Kenan Çetin and Lale Damgacı. 2022. “THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS.” Journal of Istanbul Faculty of Medicine 85, no. 4: 456-461. https://doi.org/10.26650/IUITFD.1125446

Chicago: Humanities Style

Rona, Günay, and Meral Arifoğlu and Şadiye Nuray Kadıoğlu Voyvoda and Kenan Çetin and Lale Damgacı. “THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS.” Journal of Istanbul Faculty of Medicine 85, no. 4 (Nov. 2024): 456-461. https://doi.org/10.26650/IUITFD.1125446

Harvard: Australian Style

Rona, G & Arifoğlu, M & Kadıoğlu Voyvoda, ŞN & Çetin, K & Damgacı, L 2022, 'THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS', Journal of Istanbul Faculty of Medicine, vol. 85, no. 4, pp. 456-461, viewed 18 Nov. 2024, https://doi.org/10.26650/IUITFD.1125446

Harvard: Author-Date Style

Rona, G. and Arifoğlu, M. and Kadıoğlu Voyvoda, Ş.N. and Çetin, K. and Damgacı, L. (2022) ‘THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS’, Journal of Istanbul Faculty of Medicine, 85(4), pp. 456-461. https://doi.org/10.26650/IUITFD.1125446 (18 Nov. 2024).

MLA

Rona, Günay, and Meral Arifoğlu and Şadiye Nuray Kadıoğlu Voyvoda and Kenan Çetin and Lale Damgacı. “THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS.” Journal of Istanbul Faculty of Medicine, vol. 85, no. 4, 2022, pp. 456-461. [Database Container], https://doi.org/10.26650/IUITFD.1125446

Vancouver

Rona G, Arifoğlu M, Kadıoğlu Voyvoda ŞN, Çetin K, Damgacı L. THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS. Journal of Istanbul Faculty of Medicine [Internet]. 18 Nov. 2024 [cited 18 Nov. 2024];85(4):456-461. Available from: https://doi.org/10.26650/IUITFD.1125446 doi: 10.26650/IUITFD.1125446

ISNAD

Rona, Günay - Arifoğlu, Meral - Kadıoğlu Voyvoda, ŞadiyeNuray - Çetin, Kenan - Damgacı, Lale. “THE ROLE OF DIFFUSION-WEIGHTED MR IMAGING IN EVALUATING THE RESPONSE TO STEROID THERAPY IN IDIOPATHIC GRANULOMATOUS MASTITIS LESIONS”. Journal of Istanbul Faculty of Medicine 85/4 (Nov. 2024): 456-461. https://doi.org/10.26650/IUITFD.1125446

Volume 85, Issue 42022, P. 456-461

TIMELINE

Submitted	02.06.2022
Published Online	12.10.2022

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