The Turkish Journal of Ear Nose and Throat

TR-ENT

SUBMITINFORMATION
EnglishTürkçe

Research Article


DOI :10.26650/Tr-ENT.2024.1402917   IUP :10.26650/Tr-ENT.2024.1402917    Full Text (PDF)

Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma

Saber Chebouki, Zeynep Nil Ünal, Kemal Koray Bal, Harun Gür, Onur İsmi, Murat Ünal

Objective: The paradoxical relationship between cancer and vitamin D has been known since 1990. Vitamin D receptor (VDR) is found in several tissues and, in contrast to popular belief, it is not only responsible for calcium and phosphorus metabolism but also associated with several other metabolic events. We conducted this study to investigate the effects of these factors on head and neck cancers by examining vitamin D, calcium, and phosphorus levels and polymorphisms of the VDR genes FokI and Bsm in patients with head and neck cancer.

Material and Methods: A total of 51 patients with head and neck squamous cell carcinoma aged 31-88 years and 51 healthy individuals aged 33-89 years who applied to the otorhinolaryngology outpatient clinic of Mersin University Faculty of Medicine were included in this study.

Results: No difference was observed in the distribution of the genotype ratios of the VDR genes FokI and Bsm between the two groups. However, a statistically significant difference was found in calcium levels between the two groups.

Conclusion: An individual with known VDR gene polymorphisms can provide possible risk information regarding which disease risk group he/she is in, and VDR gene polymorphism can be used as a biomarker.

Keywords: Vitamin D, genes, neoplasms, calcium, phosphorus, real-time polymerase chain reaction

PDF View

References

  • 1. Matsushita K, Sasagawa T, Miyashita M, Ishizaki A, Morishita A, Hosaka N, et al. Oral and cervical human papillomavirus infection among female sex workers in Japan. Jpn J Infect Dis 2011;64(1):34-9. google scholar
  • 2. Rosen CJ, Adams JS, Bikle DD, Black DM, Demay MB, Manson JE, et al. The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. Endocr Rev 2012;33(3):456-92. google scholar
  • 3. Tanakol R. D Vitamin. In: Sencer E, editor . Endokrinoloji, Metabolizma ve Beslenme Hastalıkları Geriatri ilavesi ile. İstanbul: Nobel Tıp Kitapevi; 2001. pp 569-582. google scholar
  • 4. Baker AR, McDonnell DP, Hughes M, Crisp TM, Mangelsdorf DJ, Haussler MR, et al. Cloning and expression of full-length cDNA encoding human vitamin D receptor. Proc Natl Acad Sci U S A 1988;85(10):3294-8. google scholar
  • 5. Tangpricha V. Vitamin D Deficiency and Related Disorders: Practice Essentials, Background, Pathophysiology. Medscape. 2016. November 8, 2016. https://emedicine.medscape.com/ article/128762-overview?form=fpf google scholar
  • 6. Karki R, Pandya D, Elston RC, Ferlini C. Defining “mutation” and “polymorphism” in the era of personal genomics. BMC Med Genomics 2015;8:37. google scholar
  • 7. Lee JH, O’Keefe JH, Bell D, Hensrud DD,Holick MF. Vitamin D deficiency an important,common, and easily treatable cardiovascular risk factor? J Am Coll Cardiol 2008;52(24):1949-56. google scholar
  • 8. Shaikh F, Baig S, Jamal Q. Do VDR gene polymorphisms contribute to breast cancer? Asian Pac J Cancer Prev 2016;17(2):479-83. google scholar
  • 9. Ekmekçi A, Konaç E, Önen Hİ. Gen polimorfizmi ve kansere yatkınlık. Marmara Medical Journal 2008;21:282-95. google scholar
  • 10. Slattery ML. Defining dietary consumption: is the sum greater than its parts? Am J Clin Nutr 2008;88(1):14-5. google scholar
  • 11. Liu JH, Li HW, Wang JQ, Li M, Xin DQ, Na X, et al. Vitamin D receptor gene Bsm I polymorphism and the susceptibility to prostate cancer in northern Chinese Han population. Zhonghua Nan Ke Xue 2003;9(6):413-6. google scholar
  • 12. Slattery ML, Schumacher MC, Smith KR, West DW, Abd-Elghany N. Physical activity, diet, and risk of colon cancer in Utah. Am J Epidemiol 1988;128(5):989-99. google scholar
  • 13. Kawase T, Matsuo K, Suzuki T, Hirose K, Hosono S, Watanabe M, et al. Association between vitamin D and calcium intake and breast cancer risk according to menopausal status and receptor status in Japan. Cancer Sci 2010;101(5):1234-40. google scholar
  • 14. Grant WB, Garland CF. The association of solar ultraviolet B (UVB) with reducing risk of cancer: multifactorial ecologic analysis of geographic variation in age-adjusted cancer mortality rates. Anticancer Res 2006;26(4A):2687-99. google scholar
  • 15. Zhang X, Giovannucci E. Calcium, vitamin D and colorectal cancer chemoprevention. Best Pract Res Clin Gastroenterol 2011;25(4-5):485-94. google scholar
  • 16. Kornfehl J, Formanek M, Temmel A, Knerer B, Willheim M. Antiproliferative effects of the biologically active metabolite of vitamin D3 (1,25[OH]2D3) on head and neck squamous cell carcinoma cell lines. Eur Arch Otorhinolaryngol 1996;253(6):341-4. google scholar
  • 17. Gandini S, Boniol M, Haukka J, Byrnes G, Cox B, Sneyd MJ, et al. Meta-analysis of observational studies of serum 25-hydroxyvitamin D levels and colorectal, breast and prostate cancer and colorectal adenoma. Int J Cancer 2011;128(6):1414-24. google scholar
  • 18. Kim Y, Je Y. Vitamin D intake, blood 25(OH)D levels, and breast cancer risk or mortality: A meta-analysis. Br J Cancer 2014;110(11):2772-84. google scholar
  • 19. Duffy MJ, Murray A, Synnott NC, O’Donovan N, Crown J. Vitamin D analogues: Potential use in cancer treatment. Crit Rev Oncol Hematol 2017;112:190-7. google scholar
  • 20. Gandini S, Gnagnarella P, Serrano D, Pasquali E, Raimondi S. Vitamin D receptor polymorphisms and cancer. Adv Exp Med Biol 2014;810:69-105. google scholar
  • 21. Liu Z, Calderon JI, Zhang Z, Sturgis EM, Spitz MR, Wei Q. Polymorphisms of vitamin D receptor gene protect against the risk of head and neck cancer. Pharmacogenet Genomics 2005;15(3):159-65. google scholar
  • 22. Fanidi A, Muller DC, Midttun 0, Ueland PM, Vollset SE, Relton C, et al. Circulating vitamin D in relation to cancer incidence and survival of the head and neck and oesophagus in the EPIC cohort. Sci Rep 2016;6:36017. google scholar
  • 23. Bobko AA, Eubank TD, Driesschaert B, Dhimitruka I, Evans J, Mohammad R, et al. Interstitial Inorganic Phosphate as a Tumor Microenvironment Marker for Tumor Progression. Sci Rep 2017;7:41233. google scholar
  • 24. de Carvalho CCCR, Caramujo MJ. Tumor metastasis as an adaptation of tumor cells to fulfill their phosphorus requirements. Med Hypotheses 2012;78:664-7. google scholar
  • 25. Tucci M, Mosca A, Lamanna G, Porpiglia F, Terzolo M, Vana F, et al. Prognostic significance of disordered calcium metabolism in hormone-refractory prostate cancer patients with metastatic bone disease. Prostate Cancer Prostatic Dis 2009;12(1):94-9. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Chebouki, S., Ünal, Z.N., Bal, K.K., Gür, H., İsmi, O., & Ünal, M. (2024). Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat, 34(1), 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


AMA

Chebouki S, Ünal Z N, Bal K K, Gür H, İsmi O, Ünal M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat. 2024;34(1):1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


ABNT

Chebouki, S.; Ünal, Z.N.; Bal, K.K.; Gür, H.; İsmi, O.; Ünal, M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 34, n. 1, p. 1-7, 2024.


Chicago: Author-Date Style

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. 2024. “Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat 34, no. 1: 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


Chicago: Humanities Style

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. “Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat 34, no. 1 (May. 2024): 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917


Harvard: Australian Style

Chebouki, S & Ünal, ZN & Bal, KK & Gür, H & İsmi, O & Ünal, M 2024, 'Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma', The Turkish Journal of Ear Nose and Throat, vol. 34, no. 1, pp. 1-7, viewed 4 May. 2024, https://doi.org/10.26650/Tr-ENT.2024.1402917


Harvard: Author-Date Style

Chebouki, S. and Ünal, Z.N. and Bal, K.K. and Gür, H. and İsmi, O. and Ünal, M. (2024) ‘Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma’, The Turkish Journal of Ear Nose and Throat, 34(1), pp. 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917 (4 May. 2024).


MLA

Chebouki, Saber, and Zeynep Nil Ünal and Kemal Koray Bal and Harun Gür and Onur İsmi and Murat Ünal. “Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma.” The Turkish Journal of Ear Nose and Throat, vol. 34, no. 1, 2024, pp. 1-7. [Database Container], https://doi.org/10.26650/Tr-ENT.2024.1402917


Vancouver

Chebouki S, Ünal ZN, Bal KK, Gür H, İsmi O, Ünal M. Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma. The Turkish Journal of Ear Nose and Throat [Internet]. 4 May. 2024 [cited 4 May. 2024];34(1):1-7. Available from: https://doi.org/10.26650/Tr-ENT.2024.1402917 doi: 10.26650/Tr-ENT.2024.1402917


ISNAD

Chebouki, Saber - Ünal, ZeynepNil - Bal, KemalKoray - Gür, Harun - İsmi, Onur - Ünal, Murat. “Evaluation of the Relationship Between Vitamin D Receptor Gene Polymorphism and Head and Neck Squamous Cell Carcinoma”. The Turkish Journal of Ear Nose and Throat 34/1 (May. 2024): 1-7. https://doi.org/10.26650/Tr-ENT.2024.1402917



TIMELINE


Submitted10.12.2023
Accepted14.03.2024
Published Online26.03.2024

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE




Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.