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DOI :10.26650/Tr-ENT.2024.1426956   IUP :10.26650/Tr-ENT.2024.1426956    Full Text (PDF)

Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study

Bilge Tuna, Gökhan Tüzemen

Objective: Gentamicin (GM) is a potent antibiotic but is known to cause irreversible ototoxic effects. Nigella sativa oil (NSO) can offer protective prophylaxis against ototoxicity when administered prior to GM treatment. This study aims to assess the impact of delayed NSO administration on GM-induced ototoxicity using the auditory brainstem response (ABR) test.

Material and Methods: Adult male Sprague-Dawley rats were randomly divided into three groups, each consisting of six animals. All groups received intraperitoneal (i.p.) GM (120 mg/kg i.p.) for a duration of 10 days. The first two groups were given 0.3 ml/kg/day NSO for five days, while the third group received 0.9% saline for the same duration. Group 1 involves the early administration of NSO (NSOE) 10 days after starting GM, Group 2 involves the late administration of NSO (NSOL) 25 days after starting GM, and Group 3 is the saline (control) group. Hearing thresholds were recorded for both ears prior to treatment initiation and again 30 days after the start of treatment.

Results: Two rats expired and were excluded from the study. A total of 64 ABR test results were obtained. No difference was found between the pre- and post-treatment ABR values in Groups 1 and 2. However, a significant increase in ABR thresholds was observed only in Group 3. A significant difference was found in post-treatment hearing thresholds (p<0.001) between Group 3 and the other two groups.

Conclusion: The results suggest the delayed administration of NSO within a period of 30 days, whether earlier or later, to be able to effectively reverse the GM-induced ototoxic effects.

Keywords: Gentamicin, nigella sativa oil, ototoxicity, auditory brainstem response test

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APA

Tuna, B., & Tüzemen, G. (2024). Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study. The Turkish Journal of Ear Nose and Throat, 34(2), 37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956


AMA

Tuna B, Tüzemen G. Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study. The Turkish Journal of Ear Nose and Throat. 2024;34(2):37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956


ABNT

Tuna, B.; Tüzemen, G. Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 34, n. 2, p. 37-41, 2024.


Chicago: Author-Date Style

Tuna, Bilge, and Gökhan Tüzemen. 2024. “Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study.” The Turkish Journal of Ear Nose and Throat 34, no. 2: 37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956


Chicago: Humanities Style

Tuna, Bilge, and Gökhan Tüzemen. “Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study.” The Turkish Journal of Ear Nose and Throat 34, no. 2 (Mar. 2025): 37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956


Harvard: Australian Style

Tuna, B & Tüzemen, G 2024, 'Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study', The Turkish Journal of Ear Nose and Throat, vol. 34, no. 2, pp. 37-41, viewed 10 Mar. 2025, https://doi.org/10.26650/Tr-ENT.2024.1426956


Harvard: Author-Date Style

Tuna, B. and Tüzemen, G. (2024) ‘Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study’, The Turkish Journal of Ear Nose and Throat, 34(2), pp. 37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956 (10 Mar. 2025).


MLA

Tuna, Bilge, and Gökhan Tüzemen. “Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study.” The Turkish Journal of Ear Nose and Throat, vol. 34, no. 2, 2024, pp. 37-41. [Database Container], https://doi.org/10.26650/Tr-ENT.2024.1426956


Vancouver

Tuna B, Tüzemen G. Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study. The Turkish Journal of Ear Nose and Throat [Internet]. 10 Mar. 2025 [cited 10 Mar. 2025];34(2):37-41. Available from: https://doi.org/10.26650/Tr-ENT.2024.1426956 doi: 10.26650/Tr-ENT.2024.1426956


ISNAD

Tuna, Bilge - Tüzemen, Gökhan. “Is Gentamicin-Induced Ototoxicity Reversible with Delayed Administration of Nigella Sativa Oil? An Experimental Study”. The Turkish Journal of Ear Nose and Throat 34/2 (Mar. 2025): 37-41. https://doi.org/10.26650/Tr-ENT.2024.1426956



TIMELINE


Submitted28.01.2024
Accepted29.04.2024
Published Online04.06.2024

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