The Turkish Journal of Ear Nose and Throat

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Research Article


DOI :10.26650/Tr-ENT.2025.1602039   IUP :10.26650/Tr-ENT.2025.1602039    Full Text (PDF)

Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre

Mehmet Murat Günay, Mehmet Furkan Doğan, İlker Akyıldız, Sibel Alicura Tokgöz, Gökhan Toptaş, Muharrem Dağlı, Mustafa Tarık Alay

Objective: This study assesses the demographic and clinical characteristics, diagnostic and treatment methods, and long-term outcomes of patients diagnosed with and treated for otogenic skull base osteomyelitis (OSBO). Second, we attempted to determine the effect of hyperbaric oxygen treatment (HBOT) on the treatment of OSBO.

Material and Methods: We conducted a retrospective analysis of the medical records of 17 patients hospitalised with an OSBO diagnosis in our clinic from 2017 to 2024. We reviewed the demographic infor mation, symptoms, laboratory results, imaging and treatment methods, length of hospital stay, associated complications, and follow-up periods.

Results: Nearly all patients, except one, were elderly males (mean age: 68.9 years; range: 57–81 years). All patients had type 2 DM, with 88.2% (n=15) having multiple comorbidities, including hypertension and coronary artery disease. The most common symptoms were otalgia, hearing loss, and otorrhea, with cranial nerve (CN) palsy observed in 70.6% (n=12). Five patients experienced single CN involvement (CN VII in three, CN XII in one, and CN VI in one), while seven had multiple CN palsy. The mean length of hospital stay was 45 days (range: 21–80 days). In addition to intravenous antibiotic therapy, hyperbaric oxygen therapy (HBOT) was administered to 52.9% (n=9). In the HBOT group, no significant reduction was observed in morbidity or length of hospital stay. During the 7-year follow-up period, mortality occurred in 17.6% (n=3).

Conclusion: OSBO should be considered as a differential diagnosis in elderly diabetic patients with persistent otalgia and otorrhea who do not respond to empirical antibiotic therapy. Although our study did not reveal any significant effects of HBOT on OSBO prognosis or length of hospital stay, randomised controlled trials are needed to assess its potential benefits.

Keywords: Skull base osteomyelitis, temporal bone osteomyelitis, malignant otitis externa, hyperbaric oxygen therapy, cranial nerve palsy, diabetes mellitus

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APA

Günay, M.M., Doğan, M.F., Akyıldız, İ., Alicura Tokgöz, S., Toptaş, G., Dağlı, M., & Alay, M.T. (2021). Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre. The Turkish Journal of Ear Nose and Throat, 0(0), -. https://doi.org/10.26650/Tr-ENT.2025.1602039


AMA

Günay M M, Doğan M F, Akyıldız İ, Alicura Tokgöz S, Toptaş G, Dağlı M, Alay M T. Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre. The Turkish Journal of Ear Nose and Throat. 2021;0(0):-. https://doi.org/10.26650/Tr-ENT.2025.1602039


ABNT

Günay, M.M.; Doğan, M.F.; Akyıldız, İ.; Alicura Tokgöz, S.; Toptaş, G.; Dağlı, M.; Alay, M.T. Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre. The Turkish Journal of Ear Nose and Throat, [Publisher Location], v. 0, n. 0, p. -, 2021.


Chicago: Author-Date Style

Günay, Mehmet Murat, and Mehmet Furkan Doğan and İlker Akyıldız and Sibel Alicura Tokgöz and Gökhan Toptaş and Muharrem Dağlı and Mustafa Tarık Alay. 2021. “Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre.” The Turkish Journal of Ear Nose and Throat 0, no. 0: -. https://doi.org/10.26650/Tr-ENT.2025.1602039


Chicago: Humanities Style

Günay, Mehmet Murat, and Mehmet Furkan Doğan and İlker Akyıldız and Sibel Alicura Tokgöz and Gökhan Toptaş and Muharrem Dağlı and Mustafa Tarık Alay. “Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre.” The Turkish Journal of Ear Nose and Throat 0, no. 0 (Mar. 2025): -. https://doi.org/10.26650/Tr-ENT.2025.1602039


Harvard: Australian Style

Günay, MM & Doğan, MF & Akyıldız, İ & Alicura Tokgöz, S & Toptaş, G & Dağlı, M & Alay, MT 2021, 'Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre', The Turkish Journal of Ear Nose and Throat, vol. 0, no. 0, pp. -, viewed 10 Mar. 2025, https://doi.org/10.26650/Tr-ENT.2025.1602039


Harvard: Author-Date Style

Günay, M.M. and Doğan, M.F. and Akyıldız, İ. and Alicura Tokgöz, S. and Toptaş, G. and Dağlı, M. and Alay, M.T. (2021) ‘Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre’, The Turkish Journal of Ear Nose and Throat, 0(0), pp. -. https://doi.org/10.26650/Tr-ENT.2025.1602039 (10 Mar. 2025).


MLA

Günay, Mehmet Murat, and Mehmet Furkan Doğan and İlker Akyıldız and Sibel Alicura Tokgöz and Gökhan Toptaş and Muharrem Dağlı and Mustafa Tarık Alay. “Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre.” The Turkish Journal of Ear Nose and Throat, vol. 0, no. 0, 2021, pp. -. [Database Container], https://doi.org/10.26650/Tr-ENT.2025.1602039


Vancouver

Günay MM, Doğan MF, Akyıldız İ, Alicura Tokgöz S, Toptaş G, Dağlı M, Alay MT. Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre. The Turkish Journal of Ear Nose and Throat [Internet]. 10 Mar. 2025 [cited 10 Mar. 2025];0(0):-. Available from: https://doi.org/10.26650/Tr-ENT.2025.1602039 doi: 10.26650/Tr-ENT.2025.1602039


ISNAD

Günay, MehmetMurat - Doğan, MehmetFurkan - Akyıldız, İlker - Alicura Tokgöz, Sibel - Toptaş, Gökhan - Dağlı, Muharrem - Alay, MustafaTarık. “Otogenic Skull Base Osteomyelitis: Clinical Presentation, Diagnostic and Therapeutic Challenges, and Long-Term Outcomes from a Single Tertiary Centre”. The Turkish Journal of Ear Nose and Throat 0/0 (Mar. 2025): -. https://doi.org/10.26650/Tr-ENT.2025.1602039



TIMELINE


Submitted16.12.2024
Accepted14.01.2025
Published Online30.01.2025

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