Mi̇krobi̇yotanın İnsan Sağlığı Üzeri̇ne Etki̇leri̇

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DOI :10.26650/B/LS34CH11CH22/2024.011.006   IUP :10.26650/B/LS34CH11CH22/2024.011.006    Tam Metin (PDF)

Fekal Mi̇krobi̇yota Transplantasyonunun Çocuk Hastalarda Kullanımı

Tuğçe Göksu Yılmaz, Elif Türkmen

İntestinal mikrobiyota; metabolik, sistemik ve immünolojik birçok olayda önemli rol oynar. Bu bağlamda disbiyozisin; hem gastrointestinal sistem (GİS) ile ilgili hem de GİS dışı birçok hastalığın patogenezinde etkili olduğu kabul edilmektedir. Fekal mikrobiyota transplantasyonu (FMT); sağlıklı mikrobiyotaya sahip bir donörden alınan gaitanın, hasta bireyin GİS’ine transfer edilmesi işlemidir; böylece bozulmuş olan mikrobiyota sağlıklı bir flora ile değiştirilmiş olur. Transplantasyonun alıcıda yeni bir hastalık hali yaratmaması adına uygun endikasyonların konulması ve donörlerin ayrıntılı şekilde incelenmesi önem arz etmektedir. Pediatrik yaş grubunda FMT uygulaması erişkinlerden farklılıklar içermektedir. Tekrarlayan Clostridium difficile enfeksiyonu, FDA onaylı bir tedavi yöntemi olup, FMT’nin en sık yapıldığı endikasyondur. Buna ek olarak hem erişkin hem pediatrik popülasyonda, başta inflamatuvar bağırsak hastalığı olmak üzere disbiyozisin neden olduğu birçok hastalıkta, kullanımı giderek yaygınlaşan, etkin ve güvenli bir tedavi yöntemidir.


Anahtar Kelimeler: Fekal mikrobiyota transplantasyonu, mikrobiyom, intestinal flora
DOI :10.26650/B/LS34CH11CH22/2024.011.006   IUP :10.26650/B/LS34CH11CH22/2024.011.006    Tam Metin (PDF)

The Use of Fecal Microbiota Transplantation in Pediatric Patients

Tuğçe Göksu Yılmaz, Elif Türkmen

Intestinal microbiota plays an important role in many metabolic, systemic and immunologic events. In this context, dysbiosis is recognized to be effective in the pathogenesis of many gastrointestinal and non-GI diseases. Fecal microbiota transplantation (FMT) is the process of transferring stool from a donor with a healthy microbiota into the GI tract of a sick individual, thus replacing the impaired microbiota with a healthy flora. It is important to establish appropriate indications and to thoroughly examine donors so that transplantation does not create a new disease state in the recipient. FMT application in the pediatric age group includes differences from adults. Recurrent Clostridium difficile infection is an FDA-approved treatment method and is the most common indication for FMT. In addition, it is an effective and safe treatment modality that is increasingly being used in many diseases primarily inflammatory bowel diseases caused by dysbiosis in both adult and pediatric populations.


Anahtar Kelimeler: Fecal microbiota transplantation, microbiome, intestinal flora

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