Davetli Derleme

DOI :10.26650/eor.20241423117 IUP :10.26650/eor.20241423117 Tam Metin (PDF)

Apikal periodontitiste inflamatuar mediatörlerin özü

Nikola Milojevic, Ema Krdzovic Lazic, Lazar Lukic, Dobroslav Puresevic, Milana Markovic, Aleksandar Jakovljevic

Apikal periodontitis (AP), dişlerin periradiküler dokularının nekrotik pulpa ile kronik inflamatuar reaksiyonunu ifade eder. AP çok faktörlü bir hastalık olarak kabul edilmesine rağmen, enfekte kök kanallarından farklı mikroorganizmalar ve bunların virülans faktörlerinin periradiküler inflamatuar sürecin birincil nedeni olduğu düşünülmektedir. Mikroplar ve konakçı arasındaki etkileşim, bağışıklığın doğuştan gelen ve adaptif bileşenlerinin aktivasyonunu içeren inflamatuar bir olaylar dizisine yol açar. AP'de farklı bağışıklık hücrelerinin aktivasyonuna, inflamasyon aracıları olarak bilinen farklı moleküller aracılık eder. Bu moleküller iltihaplı periapikal bölgede çeşitli ağ ilişkileri kurar ve alveolar kemik emilimini indükler. Bu derleme makalesi, sitokinler, matriks metalloproteinazlar, kemik rezorpsiyon düzenleyicileri ve AP'de alveoler kemik rezorpsiyonunda rol oynayan oksidatif stres bileşenleri dahil olmak üzere bazı inflamatuar mediatörlerle ilgili mevcut bilgileri sunmayı amaçlamaktadır.

Anahtar Kelimeler: periapikal periodontitis, sitokinler, oksidatif stres, matriks metalloproteinazlar, kemik rezorpsiyonu

DOI :10.26650/eor.20241423117 IUP :10.26650/eor.20241423117 Tam Metin (PDF)

Inflammatory mediators’ essence in apical periodontitis

Nikola Milojevic, Ema Krdzovic Lazic, Lazar Lukic, Dobroslav Puresevic, Milana Markovic, Aleksandar Jakovljevic

Apical periodontitis (AP) represents chronic inflammatory reaction of periradicular tissues of teeth with necrotic pulp. Although AP has been considered as a multifactorial disease, different microorganisms and their virulence factors from infected root canals are considered to be the primary cause of periradicular inflammatory process. The interplay between microbes and host leads to an inflammatory cascade of events that includes activation of innate and adaptive components of immunity. Activation of different immune cells in AP is intermediated by different molecules known as mediators of inflammation. These molecules establish various network interrelationships in the inflamed periapical area and induce alveolar bone resorption. This narrative review aimed to explore and present the current knowledge of selected inflammatory mediators, including cytokines, matrix metalloproteinases, bone resorption regulators and components of oxidative stress involved in the alveolar bone resorption in AP.

Anahtar Kelimeler: periapical periodontitis, cytokines, oxidative stress, matrix metalloproteinases, bone resorption

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APA

Milojevic, N., Krdzovic Lazic, E., Lukic, L., Puresevic, D., Markovic, M., & Jakovljevic, A. (2019). Apikal periodontitiste inflamatuar mediatörlerin özü. European Oral Research, 0(0), -. https://doi.org/10.26650/eor.20241423117

AMA

Milojevic N, Krdzovic Lazic E, Lukic L, Puresevic D, Markovic M, Jakovljevic A. Apikal periodontitiste inflamatuar mediatörlerin özü. European Oral Research. 2019;0(0):-. https://doi.org/10.26650/eor.20241423117

ABNT

Milojevic, N.; Krdzovic Lazic, E.; Lukic, L.; Puresevic, D.; Markovic, M.; Jakovljevic, A. Apikal periodontitiste inflamatuar mediatörlerin özü. European Oral Research, [Publisher Location], v. 0, n. 0, p. -, 2019.

Chicago: Author-Date Style

Milojevic, Nikola, and Ema Krdzovic Lazic and Lazar Lukic and Dobroslav Puresevic and Milana Markovic and Aleksandar Jakovljevic. 2019. “Apikal periodontitiste inflamatuar mediatörlerin özü.” European Oral Research 0, no. 0: -. https://doi.org/10.26650/eor.20241423117

Chicago: Humanities Style

Milojevic, Nikola, and Ema Krdzovic Lazic and Lazar Lukic and Dobroslav Puresevic and Milana Markovic and Aleksandar Jakovljevic. “Apikal periodontitiste inflamatuar mediatörlerin özü.” European Oral Research 0, no. 0 (May. 2024): -. https://doi.org/10.26650/eor.20241423117

Harvard: Australian Style

Milojevic, N & Krdzovic Lazic, E & Lukic, L & Puresevic, D & Markovic, M & Jakovljevic, A 2019, 'Apikal periodontitiste inflamatuar mediatörlerin özü', European Oral Research, vol. 0, no. 0, pp. -, viewed 4 May. 2024, https://doi.org/10.26650/eor.20241423117

Harvard: Author-Date Style

Milojevic, N. and Krdzovic Lazic, E. and Lukic, L. and Puresevic, D. and Markovic, M. and Jakovljevic, A. (2019) ‘Apikal periodontitiste inflamatuar mediatörlerin özü’, European Oral Research, 0(0), pp. -. https://doi.org/10.26650/eor.20241423117 (4 May. 2024).

MLA

Milojevic, Nikola, and Ema Krdzovic Lazic and Lazar Lukic and Dobroslav Puresevic and Milana Markovic and Aleksandar Jakovljevic. “Apikal periodontitiste inflamatuar mediatörlerin özü.” European Oral Research, vol. 0, no. 0, 2019, pp. -. [Database Container], https://doi.org/10.26650/eor.20241423117

Vancouver

Milojevic N, Krdzovic Lazic E, Lukic L, Puresevic D, Markovic M, Jakovljevic A. Apikal periodontitiste inflamatuar mediatörlerin özü. European Oral Research [Internet]. 4 May. 2024 [cited 4 May. 2024];0(0):-. Available from: https://doi.org/10.26650/eor.20241423117 doi: 10.26650/eor.20241423117

ISNAD

Milojevic, Nikola - Krdzovic Lazic, Ema - Lukic, Lazar - Puresevic, Dobroslav - Markovic, Milana - Jakovljevic, Aleksandar. “Apikal periodontitiste inflamatuar mediatörlerin özü”. European Oral Research 0/0 (May. 2024): -. https://doi.org/10.26650/eor.20241423117

Sayı 02019, S. -

ZAMAN ÇİZELGESİ

Gönderim	18.01.2024
Kabul	15.02.2024
Çevrimiçi Yayınlanma	29.02.2024

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European Oral Research