Araştırma Makalesi


DOI :10.26650/experimed.1438153   IUP :10.26650/experimed.1438153    Tam Metin (PDF)

Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population

Nur Çınar ŞirinSerhat KılınçCanan KüçükgerginParvana MikailovaSelçuk ErdemMehmet Öner ŞanlıFaruk ÖzcanŞule Seçkin

Objective: Renal cell carcinoma (RCC) is considered as a major type of cancer of the kidney and is estimated to account for about 2-3% of all malignancies in adults. DNA repair mechanisms play a crucial role in defending genomic integrity against DNA damage, and defects in DNA repair mechanisms are associated with cancer susceptibility. The XRCC3 gene plays a pivotal role in the DNA repair system through homologous recombination and chromosomal activity. Therefore, our research aimed to clarify whether XRCC3 Thr241Met polymorphism affects the initiation and progression of RCC.

Materials and Methods: This study included 129 patients with RCC and 212 healthy individuals. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was employed to analyze XRCC3 Thr241Met gene polymorphism using SPSS 23 software to facilitate data analysis.

Results: Our results revealed no remarkable differences in the genotype and allele frequencies of the Thr241Met polymorphism of XRCC3 between the patient and control groups. However, a greater risk of RCC was reported for the variant (Met/Met) genotype of XRCC3 gene polymorphism, particularly among smokers.

Conclusion: Although the XRCC3 Thr241Met polymorphism may not significantly influence RCC initiation and progression in a Turkish population, smoking seems to amplify the risk associated with the (Met/Met) genotype of XRCC3 gene polymorphism.


PDF Görünüm

Referanslar

  • 1. Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin 2021; 71(3): 209-49. google scholar
  • 2. Hsieh JJ, Purdue MP, Signoretti S, Swanton C, Albiges L, Schmidinger M et al. Renal cell carcinoma. Nat Rev Dis Primers 2017; 3(1): 1-19. google scholar
  • 3. Chow WH, Dong LM, Devesa SS. Epidemiology and risk factors for kidney cancer. Nat Rev Urol 2010; 7(5): 245-57. google scholar
  • 4. Nelson EC, Evans CP, Lara Jr PN. Renal cell carcinoma: current status and emerging therapies. Cancer Treat Rev 2007; 33(3): 299313. google scholar
  • 5. Horikawa Y, Wood CG, Yang H, Zhao H, Ye Y, Gu J et al. Single nucleotide polymorphisms of microRNA machinery genes modify the risk of renal cell carcinoma. Clin Cancer Res 2008; 14(23): 795662. google scholar
  • 6. Sharma R, Lewis S, Wlodarski MW. DNA repair syndromes and cancer: insights into genetics and phenotype patterns. Front Pediatr 2020; 8: 570084. google scholar
  • 7. Michalska MM, Samulak D, Romanowicz H, Jabtonski F, Smolarz B. Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and ovarian cancer in Polish women. Exp Mol Pathol 2016; 100(2): 243-7. google scholar
  • 8. Ozoran E, Trabulus FDC, Erhan D, Batar B, Guven M. Association of XRCC3, XRCC4, BAX, and BCL-2 polymorphisms with the risk of breast cancer. Int J Breast Cancer 2022; 2022: 5817841. google scholar
  • 9. Liu Q, Peng Q, Zhang B, Tan Y. X-ray cross-complementing family: the bridge linking DNA damage repair and cancer. J Transl Med 2023; 21(1): 602. google scholar
  • 10. Longo MA, Roy S, Chen Y, Tomaszowski KH, Arvai AS, Pepper JT et al. RAD51C-XRCC3 structure and cancer patient mutations define DNA replication roles. Nat Commun 2023; 14(1): 4445. google scholar
  • 11. Bonilla B, Hengel SR, Grundy MK, Bernstein KA. RAD51 gene family structure and function. Annu Rev Genet 2020; 54: 25-46. google scholar
  • 12. Matullo G, Palli D, Peluso M, Guarrera S, Carturan S, Celentano et al. XRCC1, XRCC3, XPD gene polymorphisms, smoking and 32 P-DNA adducts in a sample of healthy subjects. Carcinogenesis 2001; 22(9): 1437-45. google scholar
  • 13. Xie Z, Peng W, Li Q, Cheng W, Zhao X. Ethnicity-stratified analysis of the association between XRCC3 Thr241Met polymorphism and leukemia: an updated meta-analysis. BMC Med Genomics 2021; 14(1): 1-11. google scholar
  • 14. Qin XP, Zhou Y, Chen Y, Li NN, Wu XT. XRCC3 Thr241Met polymorphism and gastric cancer susceptibility: A meta-analysis. Clin Res Hepatol Gastroenterol 2014; 38(2): 226-34. google scholar
  • 15. Osawa K, Nakarai C, Uchino K, Yoshimura M, Tsubota N, Takahashi J et al. XRCC3 gene polymorphism is associated with survival in Japanese lung cancer patients. Int J Mol Sci 2012; 13(12): 16658-67. google scholar
  • 16. Procopciuc L, Osian G. Interaction between lifestyle factors and the XRCC1, XPD, and XRCC3 genetic variations modulates the risk for sporadic colorectal cancer. Rev Rom Med Lab 2014; 22(1): 129-41. google scholar
  • 17. Wang Z, Zhang W. Association between XRCC3 Thr241Met polymorphism and colorectal cancer risk. Tumor Biology 2013; 34: 1421-29. google scholar
  • 18. Le Marchand L, Donlon T, Lum-Jones A, Seifried A. Association of the hOGG1 Ser326Cys polymorphism with lung cancer risk. Cancer Epidemiol Biomarkers Prev 2022; 11: 409-12. google scholar
  • 19. Bahadoram S, Davoodi M, Hassanzadeh S, Bahadoram M, Barahman M, Mafakher L. Renal cell carcinoma: An overview of the epidemiology, diagnosis, and treatment. G Ital Nefrol 2022; 39(3): 2022-vol3. google scholar
  • 20. Alhmoud JF, Woolley JF, Al Moustafa AE, Malki MI. DNA damage/ repair management in cancers. Cancers 2020; 12 (4): 1050. google scholar
  • 21. Fan J, Liu W, Zhang M, Xing C. A literature review and systematic meta-analysis on XRCC3 Thr241Met polymorphism associating with susceptibility of oral cancer. Oncol Lett 2019; 18(3): 3265-73. google scholar
  • 22. dos Santos Pereira J, Fontes FL, de Medeiros SRB, de Almeida Freitas R, de Souza LB, da Costa Miguel MC. Association of the XPD and XRCC3 gene polymorphisms with oral squamous cell carcinoma in a Northeastern Brazilian population: A pilot study. Arch Oral Biol 2016; 64, 19-23. google scholar
  • 23. Loghin A, Banescu C, Nechifor-Boila A, Chibelean C, Orsolya M, Nechifor-Boila A et al. XRCC3 Thr241Met and XPD Lys751Gln gene polymorphisms and risk of clear cell renal cell carcinoma. Cancer Biomarkers 2016; 16(2): 211-7. google scholar
  • 24. Hirata H, Hinoda Y, Matsuyama H, Tanaka Y, Okayama N, Suehiro Y et al. Polymorphisms of DNA repair genes are associated with renal cell carcinoma. Biochem Biophys Res Commun 2006; 342(4): 1058-62. google scholar
  • 25. Neumann AS, Sturgis EM, Wei Q. Nucleotide excision repair as a marker for susceptibility to tobacco-related cancers: a review of molecular epidemiological studies. Mol Carcinog 2005; 42(2): 6592. google scholar
  • 26. Improta G, Sgambato A, Bianchino G, Zupa A, Grieco V, La Torre G et al. A. Polymorphisms of the DNA repair genes XRCC1 and XRCC3 and risk of lung and colorectal cancer: a case-control study in a Southern Italian population. Anticancer Res 2008; 28(5B): 2941-6. google scholar
  • 27. Zhu X, Zhong Z, Zhang X, Zhao X, Xu R, Ren W. et al. DNA repair gene XRCC3 T241M polymorphism and bladder cancer risk in a Chinese population. Genet Test Mol Biomark 2012; 16(6): 640-3. google scholar
  • 28. Hu J, Wang N, Wang YJ. XRCC3 and RAD51 expression are associated with clinical factors in breast cancer. PLoS One 2013; 8(8): e72104. google scholar

Atıflar

Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın


DIŞA AKTAR



APA

Çınar Şirin, N., Kılınç, S., Küçükgergin, C., Mikailova, P., Erdem, S., Şanlı, M.Ö., Özcan, F., & Seçkin, Ş. (2024). Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed, 14(2), 110-115. https://doi.org/10.26650/experimed.1438153


AMA

Çınar Şirin N, Kılınç S, Küçükgergin C, Mikailova P, Erdem S, Şanlı M Ö, Özcan F, Seçkin Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed. 2024;14(2):110-115. https://doi.org/10.26650/experimed.1438153


ABNT

Çınar Şirin, N.; Kılınç, S.; Küçükgergin, C.; Mikailova, P.; Erdem, S.; Şanlı, M.Ö.; Özcan, F.; Seçkin, Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed, [Publisher Location], v. 14, n. 2, p. 110-115, 2024.


Chicago: Author-Date Style

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. 2024. “Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed 14, no. 2: 110-115. https://doi.org/10.26650/experimed.1438153


Chicago: Humanities Style

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed 14, no. 2 (Dec. 2024): 110-115. https://doi.org/10.26650/experimed.1438153


Harvard: Australian Style

Çınar Şirin, N & Kılınç, S & Küçükgergin, C & Mikailova, P & Erdem, S & Şanlı, MÖ & Özcan, F & Seçkin, Ş 2024, 'Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population', Experimed, vol. 14, no. 2, pp. 110-115, viewed 22 Dec. 2024, https://doi.org/10.26650/experimed.1438153


Harvard: Author-Date Style

Çınar Şirin, N. and Kılınç, S. and Küçükgergin, C. and Mikailova, P. and Erdem, S. and Şanlı, M.Ö. and Özcan, F. and Seçkin, Ş. (2024) ‘Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population’, Experimed, 14(2), pp. 110-115. https://doi.org/10.26650/experimed.1438153 (22 Dec. 2024).


MLA

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed, vol. 14, no. 2, 2024, pp. 110-115. [Database Container], https://doi.org/10.26650/experimed.1438153


Vancouver

Çınar Şirin N, Kılınç S, Küçükgergin C, Mikailova P, Erdem S, Şanlı MÖ, Özcan F, Seçkin Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed [Internet]. 22 Dec. 2024 [cited 22 Dec. 2024];14(2):110-115. Available from: https://doi.org/10.26650/experimed.1438153 doi: 10.26650/experimed.1438153


ISNAD

Çınar Şirin, Nur - Kılınç, Serhat - Küçükgergin, Canan - Mikailova, Parvana - Erdem, Selçuk - Şanlı, MehmetÖner - Özcan, Faruk - Seçkin, Şule. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population”. Experimed 14/2 (Dec. 2024): 110-115. https://doi.org/10.26650/experimed.1438153



ZAMAN ÇİZELGESİ


Gönderim17.05.2024
Kabul12.08.2024
Çevrimiçi Yayınlanma26.08.2024

LİSANS


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.