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DOI :10.26650/experimed.1438153   IUP :10.26650/experimed.1438153    Tam Metin (PDF)

Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population

Nur Çınar ŞirinSerhat KılınçCanan KüçükgerginParvana MikailovaSelçuk ErdemMehmet Öner ŞanlıFaruk ÖzcanŞule Seçkin

Objective: Renal cell carcinoma (RCC) is considered as a major type of cancer of the kidney and is estimated to account for about 2-3% of all malignancies in adults. DNA repair mechanisms play a crucial role in defending genomic integrity against DNA damage, and defects in DNA repair mechanisms are associated with cancer susceptibility. The XRCC3 gene plays a pivotal role in the DNA repair system through homologous recombination and chromosomal activity. Therefore, our research aimed to clarify whether XRCC3 Thr241Met polymorphism affects the initiation and progression of RCC.

Materials and Methods: This study included 129 patients with RCC and 212 healthy individuals. The polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was employed to analyze XRCC3 Thr241Met gene polymorphism using SPSS 23 software to facilitate data analysis.

Results: Our results revealed no remarkable differences in the genotype and allele frequencies of the Thr241Met polymorphism of XRCC3 between the patient and control groups. However, a greater risk of RCC was reported for the variant (Met/Met) genotype of XRCC3 gene polymorphism, particularly among smokers.

Conclusion: Although the XRCC3 Thr241Met polymorphism may not significantly influence RCC initiation and progression in a Turkish population, smoking seems to amplify the risk associated with the (Met/Met) genotype of XRCC3 gene polymorphism.


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APA

Çınar Şirin, N., Kılınç, S., Küçükgergin, C., Mikailova, P., Erdem, S., Şanlı, M.Ö., Özcan, F., & Seçkin, Ş. (2024). Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed, 14(2), 110-115. https://doi.org/10.26650/experimed.1438153


AMA

Çınar Şirin N, Kılınç S, Küçükgergin C, Mikailova P, Erdem S, Şanlı M Ö, Özcan F, Seçkin Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed. 2024;14(2):110-115. https://doi.org/10.26650/experimed.1438153


ABNT

Çınar Şirin, N.; Kılınç, S.; Küçükgergin, C.; Mikailova, P.; Erdem, S.; Şanlı, M.Ö.; Özcan, F.; Seçkin, Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed, [Publisher Location], v. 14, n. 2, p. 110-115, 2024.


Chicago: Author-Date Style

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. 2024. “Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed 14, no. 2: 110-115. https://doi.org/10.26650/experimed.1438153


Chicago: Humanities Style

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed 14, no. 2 (Nov. 2024): 110-115. https://doi.org/10.26650/experimed.1438153


Harvard: Australian Style

Çınar Şirin, N & Kılınç, S & Küçükgergin, C & Mikailova, P & Erdem, S & Şanlı, MÖ & Özcan, F & Seçkin, Ş 2024, 'Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population', Experimed, vol. 14, no. 2, pp. 110-115, viewed 16 Nov. 2024, https://doi.org/10.26650/experimed.1438153


Harvard: Author-Date Style

Çınar Şirin, N. and Kılınç, S. and Küçükgergin, C. and Mikailova, P. and Erdem, S. and Şanlı, M.Ö. and Özcan, F. and Seçkin, Ş. (2024) ‘Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population’, Experimed, 14(2), pp. 110-115. https://doi.org/10.26650/experimed.1438153 (16 Nov. 2024).


MLA

Çınar Şirin, Nur, and Serhat Kılınç and Canan Küçükgergin and Parvana Mikailova and Selçuk Erdem and Mehmet Öner Şanlı and Faruk Özcan and Şule Seçkin. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population.” Experimed, vol. 14, no. 2, 2024, pp. 110-115. [Database Container], https://doi.org/10.26650/experimed.1438153


Vancouver

Çınar Şirin N, Kılınç S, Küçükgergin C, Mikailova P, Erdem S, Şanlı MÖ, Özcan F, Seçkin Ş. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population. Experimed [Internet]. 16 Nov. 2024 [cited 16 Nov. 2024];14(2):110-115. Available from: https://doi.org/10.26650/experimed.1438153 doi: 10.26650/experimed.1438153


ISNAD

Çınar Şirin, Nur - Kılınç, Serhat - Küçükgergin, Canan - Mikailova, Parvana - Erdem, Selçuk - Şanlı, MehmetÖner - Özcan, Faruk - Seçkin, Şule. Association of XRCC3 Thr241Met Polymorphism with Renal Cell Carcinoma in a Turkish Population”. Experimed 14/2 (Nov. 2024): 110-115. https://doi.org/10.26650/experimed.1438153



ZAMAN ÇİZELGESİ


Gönderim17.05.2024
Kabul12.08.2024
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