GWAS Analysis of Sudden Cardiac Death Cases in a Turkish  Population

Özel Cavlak, Gülay; Cavlak, Mehmet; Kınoğlu, Kubilay; Ceviz, Ayşe; Eronat, Allison; Kobak, Işıl; Yıldız, Mustafa; Bayraktar, Bülent; Yılmaz Aydoğan, Hülya; Öztürk, Oğuz

doi:https://dx.doi.org/10.26650/experimed.1529331

Araştırma Makalesi

DOI :10.26650/experimed.1529331 IUP :10.26650/experimed.1529331 Tam Metin (PDF)

GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population

Gülay Özel Cavlak, Mehmet Cavlak, Kubilay Kınoğlu, Ayşe Begüm Ceviz, Allison Pınar Eronat, Işıl Kobak, Bülent Şam, Mustafa Yıldız, Bülent Bayraktar, Hülya Yılmaz Aydoğan, Oğuz Öztürk

Objective: Sudden death is defined as death occurring within one hour of the onset of symptoms, with cardiovascular diseases being one of the leading causes. The most common genetic factors leading to sudden cardiac death are hypertrophic cardiomyopathy and arrhythmogenic right ventricular cardiomyopathy. In some cases, autopsies may reveal no evidence of long QT syndrome, short QT syndrome, catecholaminergic polymorphic ventricular tachycardia, or Brugada Syndrome.

Materials and Methods: We collected samples from sudden cardiac death cases aged 5–40 years (arrhythmia as Group 1, hypertrophy as Group 2, and ischemic heart disease as Group 3) , as well as from healthy athletes (control group as Group 4), and analyzed them using genomewide association study (GWAS) with a DNA microchip containing 196,725 single nucleotide polymorphism (SNP) markers thought to be associated with sudden cardiac death or other cardiovascular diseases.

Results: We detected any possible genetic variations or patterns that could elucidate the mechanisms underlying sudden cardiac death in a Turkish population. In our study group, two polymorphisms; rs2971851 and rs9609516, stood out as prominent variants compared with healthy elite athletes.

Conclusion: We aimed to identify potential genetic variations or patterns that could shed light on the mechanisms underlying sudden cardiac death in the Turkish population. In our study group, two polymorphisms, rs2971851 and rs9609516, emerged as prominent variants when compared to healthy athletes.

Anahtar Kelimeler: Sudden cardiac death, Microarray analysis, GWAS, Genetics, Forensic medicine

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DIŞA AKTAR

APA

Özel Cavlak, G., Cavlak, M., Kınoğlu, K., Ceviz, A.B., Eronat, A.P., Kobak, I., Şam, B., Yıldız, M., Bayraktar, B., Yılmaz Aydoğan, H., & Öztürk, O. (2025). GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population. Experimed, 15(1), 15-22. https://doi.org/10.26650/experimed.1529331

AMA

Özel Cavlak G, Cavlak M, Kınoğlu K, Ceviz A B, Eronat A P, Kobak I, Şam B, Yıldız M, Bayraktar B, Yılmaz Aydoğan H, Öztürk O. GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population. Experimed. 2025;15(1):15-22. https://doi.org/10.26650/experimed.1529331

ABNT

Özel Cavlak, G.; Cavlak, M.; Kınoğlu, K.; Ceviz, A.B.; Eronat, A.P.; Kobak, I.; Şam, B.; Yıldız, M.; Bayraktar, B.; Yılmaz Aydoğan, H.; Öztürk, O. GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population. Experimed, [Publisher Location], v. 15, n. 1, p. 15-22, 2025.

Chicago: Author-Date Style

Özel Cavlak, Gülay, and Mehmet Cavlak and Kubilay Kınoğlu and Ayşe Begüm Ceviz and Allison Pınar Eronat and Işıl Kobak and Bülent Şam and Mustafa Yıldız and Bülent Bayraktar and Hülya Yılmaz Aydoğan and Oğuz Öztürk. 2025. “GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population.” Experimed 15, no. 1: 15-22. https://doi.org/10.26650/experimed.1529331

Chicago: Humanities Style

Özel Cavlak, Gülay, and Mehmet Cavlak and Kubilay Kınoğlu and Ayşe Begüm Ceviz and Allison Pınar Eronat and Işıl Kobak and Bülent Şam and Mustafa Yıldız and Bülent Bayraktar and Hülya Yılmaz Aydoğan and Oğuz Öztürk. “GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population.” Experimed 15, no. 1 (May. 2025): 15-22. https://doi.org/10.26650/experimed.1529331

Harvard: Australian Style

Özel Cavlak, G & Cavlak, M & Kınoğlu, K & Ceviz, AB & Eronat, AP & Kobak, I & Şam, B & Yıldız, M & Bayraktar, B & Yılmaz Aydoğan, H & Öztürk, O 2025, 'GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population', Experimed, vol. 15, no. 1, pp. 15-22, viewed 22 May. 2025, https://doi.org/10.26650/experimed.1529331

Harvard: Author-Date Style

Özel Cavlak, G. and Cavlak, M. and Kınoğlu, K. and Ceviz, A.B. and Eronat, A.P. and Kobak, I. and Şam, B. and Yıldız, M. and Bayraktar, B. and Yılmaz Aydoğan, H. and Öztürk, O. (2025) ‘GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population’, Experimed, 15(1), pp. 15-22. https://doi.org/10.26650/experimed.1529331 (22 May. 2025).

MLA

Özel Cavlak, Gülay, and Mehmet Cavlak and Kubilay Kınoğlu and Ayşe Begüm Ceviz and Allison Pınar Eronat and Işıl Kobak and Bülent Şam and Mustafa Yıldız and Bülent Bayraktar and Hülya Yılmaz Aydoğan and Oğuz Öztürk. “GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population.” Experimed, vol. 15, no. 1, 2025, pp. 15-22. [Database Container], https://doi.org/10.26650/experimed.1529331

Vancouver

Özel Cavlak G, Cavlak M, Kınoğlu K, Ceviz AB, Eronat AP, Kobak I, Şam B, Yıldız M, Bayraktar B, Yılmaz Aydoğan H, Öztürk O. GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population. Experimed [Internet]. 22 May. 2025 [cited 22 May. 2025];15(1):15-22. Available from: https://doi.org/10.26650/experimed.1529331 doi: 10.26650/experimed.1529331

ISNAD

Özel Cavlak, Gülay - Cavlak, Mehmet - Kınoğlu, Kubilay - Ceviz, AyşeBegüm - Eronat, AllisonPınar - Kobak, Işıl - Şam, Bülent - Yıldız, Mustafa - Bayraktar, Bülent - Yılmaz Aydoğan, Hülya - Öztürk, Oğuz. “GWAS Analysis of Sudden Cardiac Death Cases in a Turkish Population”. Experimed 15/1 (May. 2025): 15-22. https://doi.org/10.26650/experimed.1529331

Cilt 15, Sayı 12025, S. 15-22

ZAMAN ÇİZELGESİ

Gönderim	09.08.2024
Kabul	20.12.2024
Çevrimiçi Yayınlanma	20.03.2025

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