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DOI :10.26650/JARHS2019-638138   IUP :10.26650/JARHS2019-638138    Tam Metin (PDF)

Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi

Hilal ŞentürkAyşe Evrim Bayrak

Kardiyovasküler hastalıklar (KVH'lar), mortalite ve morbiditenin en önemli nedeni olup çoğunlukla yetişkinlerde gözlenmektedir. KVH’ların altında yatan ana mekanizma, fibröz plakların oluşumu, düz kas hücrelerinin çoğalması ve enflamatuvar hücrelerin göçü ile meydana gelen karmaşık bir patoloji olan aterosklerozdur. Son çalışmalar, uzun kodlamayan RNA'lar (lncRNA) ve dairesel RNA'lar (circRNA) gibi protein kodlamayan RNA'ların, ateroskleroz dahil tüm KVH’ların epigenetiğinde önemli düzenleyici rollere sahip olduğunu göstermektedir. Bu derlemede, lncRNA'ların ve circRNA'ların fonksiyonel aktiviteleri ve bunların ateroskleroz ve KVH’larla olan ilişkileri özetlenmektedir. 

DOI :10.26650/JARHS2019-638138   IUP :10.26650/JARHS2019-638138    Tam Metin (PDF)

The Importance of Long Noncoding RNAs in Cardiovascular Diseases

Hilal ŞentürkAyşe Evrim Bayrak

Cardiovascular diseases (CVDs) are a leading cause of mortality and morbidity and mostly affect adults. The main underlying mechanism of CVDs is atherosclerosis and this complex pathology is caused by the formation of fibrous plaques, the proliferation of smooth muscle cells and the migration of inflammatory cells. Recent studies suggest that noncoding RNAs such as long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) have critical regulatory roles in the epigenetics of all CVDs including atherosclerosis. This review summarizes the functional roles of lncRNAs and circRNAs and their relationships with atherosclerosis and CVDs. 


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DIŞA AKTAR



APA

Şentürk, H., & Bayrak, A.E. (2019). Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 2(3), 115-125. https://doi.org/10.26650/JARHS2019-638138


AMA

Şentürk H, Bayrak A E. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2019;2(3):115-125. https://doi.org/10.26650/JARHS2019-638138


ABNT

Şentürk, H.; Bayrak, A.E. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 2, n. 3, p. 115-125, 2019.


Chicago: Author-Date Style

Şentürk, Hilal, and Ayşe Evrim Bayrak. 2019. “Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 2, no. 3: 115-125. https://doi.org/10.26650/JARHS2019-638138


Chicago: Humanities Style

Şentürk, Hilal, and Ayşe Evrim Bayrak. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 2, no. 3 (May. 2024): 115-125. https://doi.org/10.26650/JARHS2019-638138


Harvard: Australian Style

Şentürk, H & Bayrak, AE 2019, 'Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 2, no. 3, pp. 115-125, viewed 6 May. 2024, https://doi.org/10.26650/JARHS2019-638138


Harvard: Author-Date Style

Şentürk, H. and Bayrak, A.E. (2019) ‘Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 2(3), pp. 115-125. https://doi.org/10.26650/JARHS2019-638138 (6 May. 2024).


MLA

Şentürk, Hilal, and Ayşe Evrim Bayrak. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 2, no. 3, 2019, pp. 115-125. [Database Container], https://doi.org/10.26650/JARHS2019-638138


Vancouver

Şentürk H, Bayrak AE. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 6 May. 2024 [cited 6 May. 2024];2(3):115-125. Available from: https://doi.org/10.26650/JARHS2019-638138 doi: 10.26650/JARHS2019-638138


ISNAD

Şentürk, Hilal - Bayrak, AyşeEvrim. Kardiyovasküler Hastalıklarda Uzun Kodlamayan RNA’lar ve Sirküler RNA’ların Önemi”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 2/3 (May. 2024): 115-125. https://doi.org/10.26650/JARHS2019-638138



ZAMAN ÇİZELGESİ


Gönderim25.10.2019
Kabul29.11.2019
Çevrimiçi Yayınlanma30.12.2019

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