NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN  ORAL BIYOYARARLANIMIN ARTIRILMASI

Pirinçci Tok Yağmur; Güngör Sevgi; Özsoy Erginer Yıldız

doi:https://dx.doi.org/10.26650/JARHS2021-808337

Derleme

DOI :10.26650/JARHS2021-808337 IUP :10.26650/JARHS2021-808337 Tam Metin (PDF)

NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI

Yağmur Pirinçci Tok, Sevgi Güngör, Yıldız Özsoy Erginer

Nanokristal teknolojisi partikül boyutu 1000 nanometre (nm)’nin altında, herhangi bir taşıyıcı sisteme ihtiyaç duymadan katı ilaç partikülerinin üretilmesini sağlar. Sudaki çözünürlüğü düşük ilaçların partiküllerinin boyutunun küçültülmesi ile, yüzey alanlarının artması ve difüzyon tabakasının kalınlığının azaltılması k çözünürlük hızının da artışına yol açar. Buna bağlı olarak, absorpsiyon bölgesinde artan konsantrasyon gradienti bağırsak lümeni ve kan arasındaki pasif difüzyon yoluyla permeasyonu ve emilimi teşvik etmektedir. Dolayısıyla Biyofarmasötik Sınıflandırma Sistemi (BCS) Sınıf II ve IV’e ait ilaç molekülleri için nanokristal teknolojisi yaklaşımını kullanarak biyoyararlanımlarını geliştirmek ve/veya arttırmak oldukça önemlidir. Nanometre boyutunda ilaç partikülü elde edebilmek için yukarıdan aşağıya (top-down) ve aşağıdan yukarıya (bottom-up) yöntemlerinden yararlanılmaktadır. İlaç endüstrisinde uygulama kolaylığı, tekrar edilebilirliği ve ölçeklendirilebilmesi nedeniyle bilyeli değirmende yaş öğütme (BWM) ve yüksek basınçlı homojenizasyon (HPH) olarak alt bölümlere ayrılan yukarıdan aşağıya yöntemleri tercih edilmektedir. Nanokristal teknolojisi ile ilaç endüstrisinde hâlihazırda tedavide onaylanmış olan ilaç moleküllerinin daha az yan etki, daha düşük dozlar ve daha hızlı etki başlangıcı sağlayarak yeni dozaj formlarının geliştirilmesi ve yeni ilaç moleküllerinin daha iyi bir biyoyararlanımla formüle edilebilmesi amaçlanmaktadır.

Anahtar Kelimeler: Nanokristal teknolojisi, Suda çözünür ilaçlar, Oral yol, Hazırlama yöntemleri

DOI :10.26650/JARHS2021-808337 IUP :10.26650/JARHS2021-808337 Tam Metin (PDF)

NANOCRYSTAL TECHNOLOGY: INCREASING ORAL BIOAVAILABILITY OF LOW-SOLUBLE DRUGS

Yağmur Pirinçci Tok, Sevgi Güngör, Yıldız Özsoy Erginer

Nanocrystal technology enables the production of solid drug particles with a particle size below 1000 nm without the need for any carrier system. By reducing the size of the particles of drugs with low solubility in water, increasing the surface area and decreasing the thickness of the diffusion layer leads to an increase in k the solubility rate. Accordingly, the increasing concentration gradient in the absorption zone promotes permeation and absorption by passive diffusion between the intestinal lumen and blood. Therefore, it is very important to improve and / or increase their bioavailability by using the nanocrystal technology approach for drug molecules belonging to BCS Class II and IV. Top-down and bottom-up methods are used to obtain nanometer-sized drug particles. In the pharmaceutical industry, top-down methods, which are subdivided into wet milling (BWM) and high pressure homogenization (HPH), are preferred in the ball mill because of its ease of application, repeatability and scalability. With nanocrystal technology, it is aimed to create new dosage forms by providing less side effects, lower doses and faster onset of action of drug molecules that are already approved in the pharmaceutical industry. It is also aimed that new drug molecules can be formulated with better bioavailability.

Anahtar Kelimeler: Nanocrystal technology, Water-soluble drugs, Oral route, Methods of preparation

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DIŞA AKTAR

APA

Pirinçci Tok, Y., Güngör, S., & Özsoy Erginer, Y. (2022). NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 5(1), 62-70. https://doi.org/10.26650/JARHS2021-808337

AMA

Pirinçci Tok Y, Güngör S, Özsoy Erginer Y. NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2022;5(1):62-70. https://doi.org/10.26650/JARHS2021-808337

ABNT

Pirinçci Tok, Y.; Güngör, S.; Özsoy Erginer, Y. NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 5, n. 1, p. 62-70, 2022.

Chicago: Author-Date Style

Pirinçci Tok, Yağmur, and Sevgi Güngör and Yıldız Özsoy Erginer. 2022. “NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 5, no. 1: 62-70. https://doi.org/10.26650/JARHS2021-808337

Chicago: Humanities Style

Pirinçci Tok, Yağmur, and Sevgi Güngör and Yıldız Özsoy Erginer. “NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 5, no. 1 (May. 2024): 62-70. https://doi.org/10.26650/JARHS2021-808337

Harvard: Australian Style

Pirinçci Tok, Y & Güngör, S & Özsoy Erginer, Y 2022, 'NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 5, no. 1, pp. 62-70, viewed 3 May. 2024, https://doi.org/10.26650/JARHS2021-808337

Harvard: Author-Date Style

Pirinçci Tok, Y. and Güngör, S. and Özsoy Erginer, Y. (2022) ‘NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 5(1), pp. 62-70. https://doi.org/10.26650/JARHS2021-808337 (3 May. 2024).

MLA

Pirinçci Tok, Yağmur, and Sevgi Güngör and Yıldız Özsoy Erginer. “NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 5, no. 1, 2022, pp. 62-70. [Database Container], https://doi.org/10.26650/JARHS2021-808337

Vancouver

Pirinçci Tok Y, Güngör S, Özsoy Erginer Y. NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 3 May. 2024 [cited 3 May. 2024];5(1):62-70. Available from: https://doi.org/10.26650/JARHS2021-808337 doi: 10.26650/JARHS2021-808337

ISNAD

Pirinçci Tok, Yağmur - Güngör, Sevgi - Özsoy Erginer, Yıldız. “NANOKRISTAL TEKNOLOJISI: ÇÖZÜNÜRLÜĞÜ DÜŞÜK İLAÇLARIN ORAL BIYOYARARLANIMIN ARTIRILMASI”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 5/1 (May. 2024): 62-70. https://doi.org/10.26650/JARHS2021-808337

Cilt 5, Sayı 12022, S. 62-70

ZAMAN ÇİZELGESİ

Gönderim	09.10.2020
Kabul	19.11.2020
Çevrimiçi Yayınlanma	20.10.2021

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Sağlık Bilimlerinde İleri Araştırmalar Dergisi