Çocuk Dergisi

GÖNDERBİLGİ
EnglishTürkçe

Araştırma Makalesi


DOI :10.5222/j.child.2017.024   IUP :10.5222/j.child.2017.024    Tam Metin (PDF)

Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı

Aylin Yetim Şahin, Ceyhun Tıkız, Firdevs Baş

Amaç: D vitamininin kas-iskelet sistemi, immun sistem ve daha birçok mekanizma ile; B12 vitamininin ise özellikle nörokognitif fonksiyonlar olmak üzere yine çeşitli mekanizmalarla insan sağlığı üzerine önemli etkileri olduğu bilinmektedir. Bu yüzden hızlı gelişim ve değişim dönemi olan ergenlikte bu vitamin düzeylerinin istenilen sınırlar içerisinde olması önemlidir. Bu çalışmamızda amacımız ergenlerde D ve B12 vitamin düzeylerini değerlendirmekti. Gereç ve Yӧntem: İstanbul Tıp Fakültesi Ergen Sağlığı Bilim Dalı polikliniğine Ocak-Aralık 2014 tarihleri arasında nonspesifik yakınmalarla ya da kontrol amaçlı başvuran 10-20 yaş arası ergenlerin dosyaları retrospektif olarak incelendi. Serum 25 hidroksi D (25OHD) vitamin düzeyi (n=187) ve serum B12 düzeyi (n=219) ölçülmüş olan hastaların dosyaları değerlendirmeye alındı. Bulgular: Ergenlerin %56’sında serum 25OHD vitamin <20 ng/ml, %36’sında ise 20-30 ng/ml arasında idi. Cinsiyetlere ve aylara gӧre değerlendirildiğinde D vitamin düzeyleri arasında istatistiksel olarak anlamlı fark saptanmadı. Serum B12 vitamin düzeyi ergenlerin 1/3’ünde (n=78) optimal düzeyin altındaydı (<300 pg/mL). Sonuç: Ergenlerde D ve B12 vitamin eksiklikleri sıklığı yüksek bulunmuştur. Özellikle büyük şehirlerde ergenler bu vitamin eksiklikleri açısından riskli sayılmalı, D ve B12 vitamin düzeyleri yönünden değerlendirilmelidir. 

Anahtar Kelimeler: Ergen, D vitamini, B12 vitamini, vitamin eksiklikleri
DOI :10.5222/j.child.2017.024   IUP :10.5222/j.child.2017.024    Tam Metin (PDF)

Prevelance of Vitamin D and B12 Deficiency in Adolescence

Aylin Yetim Şahin, Ceyhun Tıkız, Firdevs Baş

Objective: Current guidelines recommend vitamin D supplementation during the adolescence period. Studies showed that the deficiencies of vitamins D and B12 are common in children in developing countries. On the other hand it is important to have optimum levels of vitamin D and B12 during the puberty. This study aims to evaluate the vitamin D and vitamin B12 levels of adolescents admitted to the outpatient department. Material and Method: The study was carried out in the Istanbul Medical Faculty, Department of Adolescent Health outpatient clinic between January to December 2014. The records of the adolescents aged 10-20 years were analyzed retrospectively. Of 187 adolescents were evaluated for vitamin 25 OH D and 219 were evaluated for vitamin B12. Results: Of 187 adolescents 56% had 25-OH vitamin D level ≤20 ng/ml, and 36% between 20-30 ng/ml. There were no statistically significant difference between genders or months in a year. Serum vitamin B12 levels were below the optimal level (<300 pg/mL) in one-third of adolescents (n=78). Conclusion: Vitamin D and vitamin B12 deficiencies were significantly high among adolescents attending to the outpatient department with various medical reasons. Adolescents should be considered risky in terms of lack of vitamin D and vitamin B12 levels, especially in metropolitan cities.

Anahtar Kelimeler: Adolescent, vitamin D, vitamin B12, vitamin deficiencies

PDF Görünüm

Referanslar

  • 1. Jääskeläinen T, Knekt P, Marniemi J, Sares-Jäske L, Männistö S, Heliövaara M, Järvinen R. Vitamin D status is associated with sociodemographic factors, lifestyle and metabolic health. Eur J Nutr 2013;52(2): 513-25. https://doi.org/10.1007/s00394-012-0354-0 google scholar
  • 2. Fayet F, Flood V, Petocz P, Samman S. Avoidance of meat and poultry decreases intakes of omega-3 fatty acids, vitamin B12, selenium and zinc in young women. J Hum Nutr Diet 2014;27 Suppl 2:135-42. https://doi.org/10.1111/jhn.12092 google scholar
  • 3. Seamans KM, Cashman KD. Existing and potentially novel functional markers of vitamin D status: a systematic review. Am J Clin Nut 2009;89(6):1997-2008. https://doi.org/10.3945/ajcn.2009.27230D google scholar
  • 4. Lanske B, Densmore MJ, Erben RG. Vitamin D endocrine system and osteocytes. Bonekey Rep 2014; 3:494. https://doi.org/10.1038/bonekey.2013.228 google scholar
  • 5. Webb AR, Kline L, Holick MF. Influence of season and latitude on the cutaneous synthesis of vitamin D3: exposure to winter sunlight in Boston and Edmonton will not promote vitamin D3 synthesis in human skin. J Clin Endocrinol Metab 1988;67(2):373-8. https://doi.org/10.1210/jcem-67-2-373 google scholar
  • 6. Burgaz A, Akesson A, Oster A, Michaëlsson K, Wolk A. Associations of diet, supplement use, and ultraviolet B radiation exposure with vitamin D status in Swedish women during winter. Am J Clin Nutr 2007;86(5):1399-404. google scholar
  • 7. Stagi S, Cavalli L, Iurato C, Seminara S, Brandi ML, de Martino M. Bone metabolism in children and adolescents: main characteristics of the determinants of peak bone mass. Clin Cases Miner Bone Metab 2013;10(3):172-9. google scholar
  • 8. Korf H, Decallonne B, Mathieu C. Vitamin D for infections. Curr Opin Endocrinol Diabetes Obes 2014;21(6):431-6. https://doi.org/10.1097/MED.0000000000000108 google scholar
  • 9. Thomson RL, Spedding S, Buckley JD. Vitamin D in the etiology and management of polycystic ovary syndrome. Clin Endocrinol (Oxf) 2012;77(3):343-50. https://doi.org/10.1111/j.1365-2265.2012.04434.x google scholar
  • 10. Hahn S, Haselhorst U, Tan S, Quadbeck B, Schmidt M, Roesler S, et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp Clin Endocrinol Diabetes 2006;114(10):577-83. https://doi.org/10.1055/s-2006-948308 google scholar
  • 11. Pal L, Shu J, Zeitlian G, Hickmon C. Vitamin D insufficiency in reproductive years may be contributory to ovulatory infertility and PCOS. Fertil Steril 2008; 90:S14. https://doi.org/10.1016/j.fertnstert.2008.07.382 google scholar
  • 12. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev 2013;12(10):976-89. https://doi.org/10.1016/j.autrev.2013.02.004 google scholar
  • 13. Souberbille JC, Body JJ, Lappe JM, Plebani M, Shoenfeld Y, Wang TJ, et al. Vitamin D and musculoskeletal health, cardiovascular disease, autoimmunity and cancer: Recommendations for clinical practice. Autoimmun Rev 2010;9(11):709-15. https://doi.org/10.1016/j.autrev.2010.06.009 A. Yetim ve ark., Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı 29 google scholar
  • 14. Wang SS, Hon KL, Kong AP, Pong HN, Wong GW, Leung TF. Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis. Pediatr Allergy Immunol 2014;25(1):30-5. https://doi.org/10.1111/pai.12167 google scholar
  • 15. Boonpiyathad T, Pradubpongsa P, Sangasapaviriya A. Vitamin D supplements improve urticaria symptoms and quality of life in chronic spontaneous urticaria patients: A Prospective Case-Control Study. DermatoEndocrinology 2014;6(1):e29727. google scholar
  • 16. Shils ME. Vitamin B12 ‘Cobalamin’. In: Shils ME, Olson JA, Shike M, Ross AC, eds. Modern Nutrition in Health and Disease. 9th ed. Philadelphia, Lippincott Williams&Wilkins 1999; 447-1. google scholar
  • 17. Healton EB, Savage DG, Brust JCM, Garrett TJ, Lindenbaum J. Neurologic aspects of cobalamin deficiency. Medicine (Baltimore) 1991;70:229-45. https://doi.org/10.1097/00005792-199107000-00001 google scholar
  • 18. Giedd JN, Blumenthal J, Jeffries NO, Castellanos FX, Liu H, Zijdenbos A, et al. Brain development during childhood and adolescence: a longitudinal MRI study. Nat Neurosci 1999, pp. 861-863. https://doi.org/10.1038/13158 google scholar
  • 19. Craik FI, Bialystok E. Cognition through the lifespan: mechanisms of change. Trends Cogn Sci 2006;10(3): 131-8. https://doi.org/10.1016/j.tics.2006.01.007 google scholar
  • 20. Herbert V. Vitamin B12; plant sources, requirements and assay. Am J Clin Nutr 1988;48:852-8. google scholar
  • 21. Andıran N, Çelik N, Akça H, Doğan G. Vitamin D deficiency in children and adolescents. J Clin Res Pediatr Endocrinol 2012;4(1):25-9. https://doi.org/10.4274/jcrpe.574 google scholar
  • 22. Choi DP, Oh SM, Lee J-M, Cho HM, Lee WJ, Song BM, et al. Serum 25-Hydroxyvitamin D and insulin resistance in apparently healthy adolescents. PLoS ONE 2014;9(7):e103108. https://doi.org/10.1371/journal.pone.0103108 google scholar
  • 23. Ginde AA, Liu MC, Camargo CA. Demographic differences and trends of vitamin D insufficiency in the US population, 1988-2004. Arch Intern Med 2009; 169(6):626-32. https://doi.org/10.1001/archinternmed.2008.604 google scholar
  • 24. Rajakumar K, Fernstrom JD, Holick MF, Janosky JE, Greenspan SL. Vitamin D status and response to Vitamin D(3) in obese vs. non-obese African American children. Obesity (Silver Spring) 2008;16(1):90-5. https://doi.org/10.1038/oby.2007.23 google scholar
  • 25. Currie, C, Zanotti, C, Morgan, A, et al. Social determinants of health and well-being among young people. Health Behaviour in School-aged Children (HBSC) study: International Report From the 2009/2010 survey. WHO Regional Office for Europe, (Health Policy for Children and Adolescents, No. 6), Copenhagen; 2012. google scholar
  • 26. Oberg J, Jorde R, Almås B, Emaus N, Grimnes G. Vitamin D deficiency and lifestyle risk factors in a Norwegian adolescent population. Scand J Public Health 2014;42(7):593-602. https://doi.org/10.1177/1403494814541593 google scholar
  • 27. Shah TH, Hassan M, Siddiqui TS. Subclinical nutritional rickets among adolescents in Kaghan Valley. J Coll Physicians Surg Pak 2014;24(9):663-5. google scholar
  • 28. Karagüzel G, Dilber B, Çan G, Ökten A, Değer O, Holick MF. Seasonal vitamin D status of healthy schoolchildren and predictors of low vitamin D status. J Pediatr Gastroenterol Nutr 2014;58(5):654-60. https://doi.org/10.1097/MPG.0000000000000274 google scholar
  • 29. Torun E, Genç H, Gönüllü E, Akovalı B, Ozgen IT. The clinical and biochemical presentation of vitamin D deficiency and insufficiency in children and adolescents. J Pediatr Endocrinol Metab 2013;26(5-6):469- 75. https://doi.org/10.1515/jpem-2012-0245 google scholar
  • 30. Society for Adolescent Health and Medicine. Recommended vitamin D intake and management of low vitamin D status in adolescents: a position statementof the society for adolescent health and medicine. J Adolesc Health 2013;52(6):801-3. https://doi.org/10.1016/j.jadohealth.2013.03.022 google scholar
  • 31. Dror DK, Allen LH. Dairy product intake in children and adolescents in developed countries: trends, nutritional contribution, and a review of association with health outcomes. Nutr Rev 2014;72(2):68-81. https://doi.org/10.1111/nure.12078 google scholar
  • 32. Kapil U, Bhadoria AS. Prevalence of folate, ferritin and cobalamin deficiencies amongst adolescent in India. J Family Med Prim Care 2014;3(3):247-9. https://doi.org/10.4103/2249-4863.141619 google scholar

Atıflar

Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın


DIŞA AKTAR



APA

Yetim Şahin, A., Tıkız, C., & Baş, F. (0001). Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı. Çocuk Dergisi, 17(1), 24-29. https://doi.org/10.5222/j.child.2017.024


AMA

Yetim Şahin A, Tıkız C, Baş F. Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı. Çocuk Dergisi. 0001;17(1):24-29. https://doi.org/10.5222/j.child.2017.024


ABNT

Yetim Şahin, A.; Tıkız, C.; Baş, F. Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı. Çocuk Dergisi, [Publisher Location], v. 17, n. 1, p. 24-29, 0001.


Chicago: Author-Date Style

Yetim Şahin, Aylin, and Ceyhun Tıkız and Firdevs Baş. 0001. “Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı.” Çocuk Dergisi 17, no. 1: 24-29. https://doi.org/10.5222/j.child.2017.024


Chicago: Humanities Style

Yetim Şahin, Aylin, and Ceyhun Tıkız and Firdevs Baş. “Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı.” Çocuk Dergisi 17, no. 1 (Nov. 2024): 24-29. https://doi.org/10.5222/j.child.2017.024


Harvard: Australian Style

Yetim Şahin, A & Tıkız, C & Baş, F 0001, 'Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı', Çocuk Dergisi, vol. 17, no. 1, pp. 24-29, viewed 25 Nov. 2024, https://doi.org/10.5222/j.child.2017.024


Harvard: Author-Date Style

Yetim Şahin, A. and Tıkız, C. and Baş, F. (0001) ‘Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı’, Çocuk Dergisi, 17(1), pp. 24-29. https://doi.org/10.5222/j.child.2017.024 (25 Nov. 2024).


MLA

Yetim Şahin, Aylin, and Ceyhun Tıkız and Firdevs Baş. “Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı.” Çocuk Dergisi, vol. 17, no. 1, 0001, pp. 24-29. [Database Container], https://doi.org/10.5222/j.child.2017.024


Vancouver

Yetim Şahin A, Tıkız C, Baş F. Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı. Çocuk Dergisi [Internet]. 25 Nov. 2024 [cited 25 Nov. 2024];17(1):24-29. Available from: https://doi.org/10.5222/j.child.2017.024 doi: 10.5222/j.child.2017.024


ISNAD

Yetim Şahin, Aylin - Tıkız, Ceyhun - Baş, Firdevs. “Ergenlik Döneminde D ve B12 Vitamin Eksikliklerinin Sıklığı”. Çocuk Dergisi 17/1 (Nov. 2024): 24-29. https://doi.org/10.5222/j.child.2017.024



ZAMAN ÇİZELGESİ


Gönderim06.06.2016
Kabul24.06.2016

LİSANS


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.