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DOI :10.26650/jchild.2021.1.844098   IUP :10.26650/jchild.2021.1.844098    Tam Metin (PDF)

Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi

Yöntem Yaman, Murat Elli, Kürşat Özdilli, Leyla Telhan, Nihan Bayram, Volkan Hazar, Ebru Tuğrul Sarıbeyoğlu, Şifa Şahin, Seniye Sema Anak

Giriş: Standart tedavi alan Hodgkin Lymphoma (HL) hastalarının yaklaşık %20’sinde hastalık dirençli seyredebilir veya tekrar edebilir. Tekrar eden/dirençli HL’da standart tedavi yüksek doz kemoterapi ve takip eden otolog kök hücre naklidir (OKHN). Otolog KHN sonrası tekrar eden hastalarda ise allojeneik kök hücre nakli (AKHN) önemli bir kurtarma tedavisi olarak görülmektedir. 

Amaç: Medipol Üniversitesi Tıp Fakültesi çocuk kemik iliği nakil ünitesinde OKHN ve AKHN yapılan hastalarda sonuçları değerlendirmek. 

Yöntem: Tekrar eden/dirençli HL nedeniyle 2014 Kasım ile Temmuz 2019 tarihleri arasında merkezimizde OKHN yapılan 18 olgu retrospektif olarak değerlendirilmiştir. Otolog KHN sonrası hastalığı tekrar eden ve AKHN yapılan hastalarda ayrıca değerlendirilmiştir. 

Bulgular: Onaltı hasta halen hayattadır. Onbir hastada OKHN sonrası hastalık tekrar etmiştir. Relaps eden hastalardan 10’una AKHN yapılmıştır. Bu hastalardan üçünde tekrar görülmüş olup, sekizi nakil sonrası hayattadırlar.

Anahtar Kelimeler: Brentuksimab vedotin, kontrol noktası inhibitörü, kök hücre nakli, relaps, yüksek doz kemoterapi Hodgkin Lenfoma
DOI :10.26650/jchild.2021.1.844098   IUP :10.26650/jchild.2021.1.844098    Tam Metin (PDF)

Hematopoietic Stem Cell Transplantation and High Dose Chemotherapy in Recurrent and/or Chemotherapy Resistant Hodgkin Lymphoma Cases: A Single Center Experience

Yöntem Yaman, Murat Elli, Kürşat Özdilli, Leyla Telhan, Nihan Bayram, Volkan Hazar, Ebru Tuğrul Sarıbeyoğlu, Şifa Şahin, Seniye Sema Anak

Background: Nearly 20% of patients with Hodgkin Lymphoma (HL) who receive standard treatment will relapse or have a refractory disease. Standard treatment for the Relapsed/Refractory (RR) HL is salvage high dose chemotherapy followed by autologous stem cell transplantation (AuSCT). Management of RR HL after AuSCT with allogeneic stem cell transplantation (ASCT) is also considered as an important salvage therapy.

Objective: To describe the outcome in pediatric patients with RR HL who underwent AuHSCT and ASCT in Medipol University hematopoietic stem cell transplantation center. 

Method: We retrospectively evaluated 18 pediatric patients with RR HL who underwent AHSCT between November 2014 and July 2019. The evaluation of ASCT after RR HL AuSCT is also done. 

Results: Sixteen patients are still alive. Eleven of them relapsed after AuHSCT. AllogeneicHSCT was performed on 10 patients who relapsed. Relapse was seen in three patients after AHSCT. Eight of them are still alive.

Anahtar Kelimeler: Brentuximab vedotin, check point inhibitör, high dose chemotherapy, Hodgkin Lymphoma, stem cell, relapse, transplantation

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DIŞA AKTAR



APA

Yaman, Y., Elli, M., Özdilli, K., Telhan, L., Bayram, N., Hazar, V., Tuğrul Sarıbeyoğlu, E., Şahin, Ş., & Anak, S.S. (2021). Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi. Çocuk Dergisi, 21(1), 7-12. https://doi.org/10.26650/jchild.2021.1.844098


AMA

Yaman Y, Elli M, Özdilli K, Telhan L, Bayram N, Hazar V, Tuğrul Sarıbeyoğlu E, Şahin Ş, Anak S S. Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi. Çocuk Dergisi. 2021;21(1):7-12. https://doi.org/10.26650/jchild.2021.1.844098


ABNT

Yaman, Y.; Elli, M.; Özdilli, K.; Telhan, L.; Bayram, N.; Hazar, V.; Tuğrul Sarıbeyoğlu, E.; Şahin, Ş.; Anak, S.S. Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi. Çocuk Dergisi, [Publisher Location], v. 21, n. 1, p. 7-12, 2021.


Chicago: Author-Date Style

Yaman, Yöntem, and Murat Elli and Kürşat Özdilli and Leyla Telhan and Nihan Bayram and Volkan Hazar and Ebru Tuğrul Sarıbeyoğlu and Şifa Şahin and Seniye Sema Anak. 2021. “Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi.” Çocuk Dergisi 21, no. 1: 7-12. https://doi.org/10.26650/jchild.2021.1.844098


Chicago: Humanities Style

Yaman, Yöntem, and Murat Elli and Kürşat Özdilli and Leyla Telhan and Nihan Bayram and Volkan Hazar and Ebru Tuğrul Sarıbeyoğlu and Şifa Şahin and Seniye Sema Anak. “Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi.” Çocuk Dergisi 21, no. 1 (Apr. 2024): 7-12. https://doi.org/10.26650/jchild.2021.1.844098


Harvard: Australian Style

Yaman, Y & Elli, M & Özdilli, K & Telhan, L & Bayram, N & Hazar, V & Tuğrul Sarıbeyoğlu, E & Şahin, Ş & Anak, SS 2021, 'Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi', Çocuk Dergisi, vol. 21, no. 1, pp. 7-12, viewed 20 Apr. 2024, https://doi.org/10.26650/jchild.2021.1.844098


Harvard: Author-Date Style

Yaman, Y. and Elli, M. and Özdilli, K. and Telhan, L. and Bayram, N. and Hazar, V. and Tuğrul Sarıbeyoğlu, E. and Şahin, Ş. and Anak, S.S. (2021) ‘Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi’, Çocuk Dergisi, 21(1), pp. 7-12. https://doi.org/10.26650/jchild.2021.1.844098 (20 Apr. 2024).


MLA

Yaman, Yöntem, and Murat Elli and Kürşat Özdilli and Leyla Telhan and Nihan Bayram and Volkan Hazar and Ebru Tuğrul Sarıbeyoğlu and Şifa Şahin and Seniye Sema Anak. “Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi.” Çocuk Dergisi, vol. 21, no. 1, 2021, pp. 7-12. [Database Container], https://doi.org/10.26650/jchild.2021.1.844098


Vancouver

Yaman Y, Elli M, Özdilli K, Telhan L, Bayram N, Hazar V, Tuğrul Sarıbeyoğlu E, Şahin Ş, Anak SS. Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi. Çocuk Dergisi [Internet]. 20 Apr. 2024 [cited 20 Apr. 2024];21(1):7-12. Available from: https://doi.org/10.26650/jchild.2021.1.844098 doi: 10.26650/jchild.2021.1.844098


ISNAD

Yaman, Yöntem - Elli, Murat - Özdilli, Kürşat - Telhan, Leyla - Bayram, Nihan - Hazar, Volkan - Tuğrul Sarıbeyoğlu, Ebru - Şahin, Şifa - Anak, SeniyeSema. “Hodgkin Lenfoma Nüks ve/veya Kemoterapi Dirençli Olgularda Hematopoetik Kök Hücre Nakli ve Yüksek Doz Kemoterapi: Tek Merkez Deneyimi”. Çocuk Dergisi 21/1 (Apr. 2024): 7-12. https://doi.org/10.26650/jchild.2021.1.844098



ZAMAN ÇİZELGESİ


Gönderim23.12.2020
İlk Revizyon10.03.2021
Son Revizyon16.03.2021
Kabul03.04.2021
Çevrimiçi Yayınlanma17.05.2021

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