Orijinal Araştırma


DOI :https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71   IUP :https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71    Tam Metin (PDF)

HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ

Ramin GalanderovMeryem Kürek EkenGülşah İlhanMurat KeskinAbdullah Turfanda

Amaç: Bu çalışma da ooforektomi yapılmadan histerektomi uygulanan olgularda erken overyan yetmezlik riskini ortaya koymak amaçlandı.

Gereç ve Yöntem: Bu çalışmaya; 25-50 yaş arasında, daha önceden bilateral ooferektomi geçirmemiş, menopoz veya prematüre overyan yetmezliği olmayan, çeşitli endikasyonlarla histerektomi kararı alınan 28 hasta dahil edildi. Bu hastaların ameliyat öncesi ve ameliyattan 1 ay sonrası Antimüllerian hormon (AMH), over hacmi ve antral folikül sayısı (AFS) karşılaştırıldı.

Bulgular: Ameliyat sonrası bakılan AMH değerinde, overlerin hacminde ve AFS lerde istatistiksel olarak anlamlı derecede azalma saptandı (p < 0.05).

Sonuç: Histerektomi yapılan reprodüktif dönemdeki hastalarda ooferektomi operasyonu uygun endikasyonlar dahilinde yapılmalıdır ve histerektomi yapıldıktan sonra erken menopoza girebileceği öngörülerek, menopoz semptomlarının başlaması beklenmeden yakın takip ve uygun tedavi planlanmalıdır.

DOI :https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71   IUP :https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71    Tam Metin (PDF)

Evaluation of the effects of hysterectomy on ovarian reserve by antimullerian hormone and ultrasonography.

Ramin GalanderovMeryem Kürek EkenGülşah İlhanMurat KeskinAbdullah Turfanda

Objective: Our study aimed to determine the risk of premature ovarian failure of patients to whom hysterectomy was performed without oophorectomy.

Materials and Methods: 28 hysterectomised patients due to various indications that met the eligibility criteria of age 25 to 50 years, had no history of bilateral oophorectomy, were not menopausal or premature ovarian failure, were included in this study. These patients’ AMH (Antimullarian hormone), ovarian volume and AFC (antral follicle count) were compared before and 1 month after surgery.

Results: AMH, the volume of the ovaries and the number of antral follicles revealed a significant decrease after surgery. (p<0.05)

Conclusions: Oophorectomy performed in patients of reproductive age should be made within appropriate indications. Because hysterectomised women in reproductive period may enter early menopause, strict follow-up and appropriate treatment should be carried out without waiting for menopause symptoms.


PDF Görünüm

Referanslar

  • 1. Dekel A, Efrat Z, Orvieto R, Levy T, Dicker D, Gal R.et al. The residual ovary syndrome: a 20-year experience. Eur J Obstet Gynecol Reprod Biol 1996; 68:159–64. google scholar
  • 2. Fong YF, Lim FK, Arulkumaran S. Prophylactic oophorectomy: a continuing controversy. Obstet Gynecol Surv 1998; 53:493–99. google scholar
  • 3. Reich H. Issues surrounding surgical menopause. J Reprod Med 2001;46:297–306. google scholar
  • 4. Laughlin GA, Barrett-Connor E, Kritz-Silverstein D, von Mühlen D. Hysterectomy, oophorectomy, and endogenous sex hormone levels in older women: the Rancho Bernardo study. J Clin Endocrinol Metab 2000;85:645–51. google scholar
  • 5. Judd HL, Judd GE, Lucas WE, Yen SS. Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovaryan and peripheral vein blood. J Clin Endocrinol Metab 1974;39:1020–4. google scholar
  • 6. Ossewaarde ME, Bots ML, Verbeek AL, Peeters PH, van der Graaf Y, Grobbee DE, et al. Age at menopause, cause-specific mortality and total life expectancy. Epidemiology 2005;16:556–62. google scholar
  • 7. Colditz GA, Willett WC, Stampfer MJ, Rosner B, Speizer FE, Hennekens CH. Menopause and the risk of coronary heart disease in women. N Engl J Med 1987;316:1105–10. google scholar
  • 8. Falkeborn M, Schairer C, Naessén T, Persson I. Risk of myocardial infarction after oophorectomy and hysterectomy. J Clin Epidemiol 2000;53:832–7. google scholar
  • 9. Atsma F, Bartelink ML, Grobbee DE, van der Schouw YT. Postmenopausal status and early menopause as independent risk factors for cardiovascular disease: a meta-analysis. Menopause 2006;13:265–79. google scholar
  • 10. Armstrong K, Schwartz JS, Randall T, Rubin SC, Weber B. Hormone replacement therapy and life expectancy after prophylactic oophorectomy in women with BRCA1/2 mutations: a decision analysis. J Clin Oncol 2004;22:1045–54. google scholar
  • 11. Lambalk CB. Value of elevated basal follicle-stimulating hormone levels and the differential diagnosis during the diagnostic subfertility work-up. Fertil Steril 2003;79:489-90. google scholar
  • 12. Tsepelidis S, Devreker F, Demeestere I, Flahaut A, Gervy Ch, Englert Y.et al. Stable serum levels of anti- Mullerian hormone during the menstrual cycle: a prospective study in normo-ovulatory women. Hum Reprod 2007;22:1837-40. google scholar
  • 13. Van Rooij IA, Tonkelaar Id, Broekmans FJ, Looman CW, Scheffer GJ, de Jong FH, et al. Anti-Mülleryan hormone is a promising predictor for the occurrence of the menopausal transition. Menopause 2004;11:601–6. google scholar
  • 14. Atabekoglu C, Taskin S, Kahraman K, Gemici A, Taskin EA, Ozmen B,et al. The effect of total abdominal hysterectomy on serum anti-Mullerian hormone levels:a pilot study. Climacteric. 2012;15:393–7. google scholar
  • 15. YuanH, WangC, WangD, WangY.Comparison ofthe effect of laparoscopic supracervical and total hysterectomy for uterine fibroids on ovarian reserve by assessing serum anti-Mullerian hormone levels: a prospective cohort study. J Minim Invasive Gynecol. 2015:22:637-41. google scholar
  • 16. Moorman PG, Myers ER, Schildkraut JM, Iversen ES, Wang F, Warren N. Effect of Hysterectomy With Ovarian Preservation on Ovarian Function. Obstet Gynecol 2011;118: 1271–9 google scholar
  • 17. Wang HY, Quan S, Zhang RL, Ye HY, Bi YL, Jiang ZM, Ng EH. Comparison of serum anti-Mullerian hormone levels following hysterectomy and myomectomy for benign gynaecological conditions. Eur J Obstet Gynecol Reprod Biol. 2013;171:368-71 google scholar
  • 18. Cattanach J. Oestrogen deficiency after tubal ligation. Lancet 1985;1:847-9. google scholar
  • 19. Janson PO, Jansson I. The acute effect of hysterectomyon ovarian blood flow. Am J Obstet Gynecol 1977;127:349-52 google scholar
  • 20. Chrisman HB, Saker MB, Ryu RK, Nemcek AA Jr, Gerbie MV, Milad MP. et al. The impact of uterine fibroid embolization on resumption of menses and ovarian function. J Vasc Interv Radial 2000;11:699-703. google scholar

Atıflar

Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın


DIŞA AKTAR



APA

Galanderov, R., Kürek Eken, M., İlhan, G., Keskin, M., & Turfanda, A. (2015). HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ. İstanbul Tıp Fakültesi Dergisi, 78(3), 67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


AMA

Galanderov R, Kürek Eken M, İlhan G, Keskin M, Turfanda A. HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ. İstanbul Tıp Fakültesi Dergisi. 2015;78(3):67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


ABNT

Galanderov, R.; Kürek Eken, M.; İlhan, G.; Keskin, M.; Turfanda, A. HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ. İstanbul Tıp Fakültesi Dergisi, [Publisher Location], v. 78, n. 3, p. 67-71, 2015.


Chicago: Author-Date Style

Galanderov, Ramin, and Meryem Kürek Eken and Gülşah İlhan and Murat Keskin and Abdullah Turfanda. 2015. “HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ.” İstanbul Tıp Fakültesi Dergisi 78, no. 3: 67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


Chicago: Humanities Style

Galanderov, Ramin, and Meryem Kürek Eken and Gülşah İlhan and Murat Keskin and Abdullah Turfanda. “HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ.” İstanbul Tıp Fakültesi Dergisi 78, no. 3 (May. 2025): 67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


Harvard: Australian Style

Galanderov, R & Kürek Eken, M & İlhan, G & Keskin, M & Turfanda, A 2015, 'HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ', İstanbul Tıp Fakültesi Dergisi, vol. 78, no. 3, pp. 67-71, viewed 14 May. 2025, https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


Harvard: Author-Date Style

Galanderov, R. and Kürek Eken, M. and İlhan, G. and Keskin, M. and Turfanda, A. (2015) ‘HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ’, İstanbul Tıp Fakültesi Dergisi, 78(3), pp. 67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71 (14 May. 2025).


MLA

Galanderov, Ramin, and Meryem Kürek Eken and Gülşah İlhan and Murat Keskin and Abdullah Turfanda. “HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ.” İstanbul Tıp Fakültesi Dergisi, vol. 78, no. 3, 2015, pp. 67-71. [Database Container], https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


Vancouver

Galanderov R, Kürek Eken M, İlhan G, Keskin M, Turfanda A. HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ. İstanbul Tıp Fakültesi Dergisi [Internet]. 14 May. 2025 [cited 14 May. 2025];78(3):67-71. Available from: https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71 doi: https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71


ISNAD

Galanderov, Ramin - Kürek Eken, Meryem - İlhan, Gülşah - Keskin, Murat - Turfanda, Abdullah. “HİSTEREKTOMİ YAPILAN OLGULARDA OVER REZERVİNİN ANTİMÜLLERİAN HORMON VE ULTRASONOGRAFİ İLE DEĞERLENDİRİLMESİ”. İstanbul Tıp Fakültesi Dergisi 78/3 (May. 2025): 67-71. https://doi.org/https://doi.org/10.18017/iuitfd.13056441.2015.78/3.67-71



ZAMAN ÇİZELGESİ



PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.