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DOI :10.26650/IUITFD.2020.0086   IUP :10.26650/IUITFD.2020.0086    Tam Metin (PDF)

METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER

Senem Karabulut, Mehmet Karabulut, Didem Taştekin

Bu derlemede metastatik kolon kanseri (mKRK)’ndeki medikal alandaki güncel yenilikler değerlendirildi. mKRK tedavi kararında tümör yerleşimi önemlidir ve KRAS, NRAS, BRAF mutasyon analizi prognoz/prediktivite açısından yapılmaktadır. İmmünoterapi %5-6 ve dMMR/MSI olan hasta grubunda tedavi seçeneğidir. NeoRAS kavramı, kanıt düzeyi yüksek bilgiler artıkça yakın gelecekte daha fazla gündemde olacaktır. Günümüzdeki birçok tümör tedavisinde olduğu gibi mKRK tedavisinde de moleküler değerlendirmeler prognoz ve prediktif açıdan son derece önemli hale gelmiştir.

Anahtar Kelimeler: Metastatik kolon kanser, tedavi, yenilikler
DOI :10.26650/IUITFD.2020.0086   IUP :10.26650/IUITFD.2020.0086    Tam Metin (PDF)

WHAT’S NEW IN METASTATIC COLON CANCER TREATMENT?

Senem Karabulut, Mehmet Karabulut, Didem Taştekin

In this review, we present the current innovations in the field of metastatic colon cancer (mCRC). Tumor placement is important in the mCRC treatment decision, and KRAS, NRAS, BRAF mutation analysis is performed in terms of prognosis/predictivity. Immunotherapy is the treatment option in patients with 5-6% and dMMR/MSI. The concept of NeoRAS will become more on the agenda in the near future as high-level evidence becomes available. Molecular evaluations have become extremely important in terms of prognosis and predictions in the treatment of mCRC, as in many tumors today

Anahtar Kelimeler: Metastatic colon cancer, treatment, innovations

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DIŞA AKTAR



APA

Karabulut, S., Karabulut, M., & Taştekin, D. (2021). METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi, 84(3), 425-429. https://doi.org/10.26650/IUITFD.2020.0086


AMA

Karabulut S, Karabulut M, Taştekin D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi. 2021;84(3):425-429. https://doi.org/10.26650/IUITFD.2020.0086


ABNT

Karabulut, S.; Karabulut, M.; Taştekin, D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi, [Publisher Location], v. 84, n. 3, p. 425-429, 2021.


Chicago: Author-Date Style

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. 2021. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi 84, no. 3: 425-429. https://doi.org/10.26650/IUITFD.2020.0086


Chicago: Humanities Style

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi 84, no. 3 (Dec. 2024): 425-429. https://doi.org/10.26650/IUITFD.2020.0086


Harvard: Australian Style

Karabulut, S & Karabulut, M & Taştekin, D 2021, 'METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER', İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 3, pp. 425-429, viewed 23 Dec. 2024, https://doi.org/10.26650/IUITFD.2020.0086


Harvard: Author-Date Style

Karabulut, S. and Karabulut, M. and Taştekin, D. (2021) ‘METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER’, İstanbul Tıp Fakültesi Dergisi, 84(3), pp. 425-429. https://doi.org/10.26650/IUITFD.2020.0086 (23 Dec. 2024).


MLA

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 3, 2021, pp. 425-429. [Database Container], https://doi.org/10.26650/IUITFD.2020.0086


Vancouver

Karabulut S, Karabulut M, Taştekin D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi [Internet]. 23 Dec. 2024 [cited 23 Dec. 2024];84(3):425-429. Available from: https://doi.org/10.26650/IUITFD.2020.0086 doi: 10.26650/IUITFD.2020.0086


ISNAD

Karabulut, Senem - Karabulut, Mehmet - Taştekin, Didem. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER”. İstanbul Tıp Fakültesi Dergisi 84/3 (Dec. 2024): 425-429. https://doi.org/10.26650/IUITFD.2020.0086



ZAMAN ÇİZELGESİ


Gönderim13.07.2020
Kabul21.11.2020
Çevrimiçi Yayınlanma02.07.2021

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