İstanbul Tıp Fakültesi Dergisi

GÖNDERBİLGİ
EnglishTürkçe

Derleme


DOI :10.26650/IUITFD.2020.0086   IUP :10.26650/IUITFD.2020.0086    Tam Metin (PDF)

METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER

Senem Karabulut, Mehmet Karabulut, Didem Taştekin

Bu derlemede metastatik kolon kanseri (mKRK)’ndeki medikal alandaki güncel yenilikler değerlendirildi. mKRK tedavi kararında tümör yerleşimi önemlidir ve KRAS, NRAS, BRAF mutasyon analizi prognoz/prediktivite açısından yapılmaktadır. İmmünoterapi %5-6 ve dMMR/MSI olan hasta grubunda tedavi seçeneğidir. NeoRAS kavramı, kanıt düzeyi yüksek bilgiler artıkça yakın gelecekte daha fazla gündemde olacaktır. Günümüzdeki birçok tümör tedavisinde olduğu gibi mKRK tedavisinde de moleküler değerlendirmeler prognoz ve prediktif açıdan son derece önemli hale gelmiştir.

Anahtar Kelimeler: Metastatik kolon kanser, tedavi, yenilikler
DOI :10.26650/IUITFD.2020.0086   IUP :10.26650/IUITFD.2020.0086    Tam Metin (PDF)

WHAT’S NEW IN METASTATIC COLON CANCER TREATMENT?

Senem Karabulut, Mehmet Karabulut, Didem Taştekin

In this review, we present the current innovations in the field of metastatic colon cancer (mCRC). Tumor placement is important in the mCRC treatment decision, and KRAS, NRAS, BRAF mutation analysis is performed in terms of prognosis/predictivity. Immunotherapy is the treatment option in patients with 5-6% and dMMR/MSI. The concept of NeoRAS will become more on the agenda in the near future as high-level evidence becomes available. Molecular evaluations have become extremely important in terms of prognosis and predictions in the treatment of mCRC, as in many tumors today

Anahtar Kelimeler: Metastatic colon cancer, treatment, innovations

PDF Görünüm

Referanslar

  • 1. Weinberg BA, Marshall JL, E Salem M. The Growing Challenge of Young Adults With Colorectal Cancer. Oncology (Williston Park) 2017;31(5):381-9. google scholar
  • 2. Cremolini C, Antoniotti C, Lonardi S, Bergamo F, Cortesi E, Tomasello G, et al. Primary Tumor Sidedness and Benefit From FOLFOXIRI Plus Bevacizumab as Initial Therapy for Metastatic Colorectal Cancer. Retrospective Analysis of the TRIBE Trial by GONO. Ann Oncol 2018;29(7):1528-34. [CrossRef] google scholar
  • 3. D Arnold , B Lueza , J-Y Douillard , M Peeters , H-J Lenz, A Venook , et al. Prognostic and Predictive Value of Primary Tumour Side in Patients With RAS Wild-Type Metastatic Colorectal Cancer Treated With Chemotherapy and EGFR Directed Antibodies in Six Randomized Trials. Ann Oncol 2017;28(8):1713-29. [CrossRef] google scholar
  • 4. Holchet JW, Ricard I, Stintzing S, Modest DP, Heinemann V, et al. The Relevance of Primary Tumour Location in Patients With Metastatic Colorectal Cancer: A Meta-Analysis of First-Line Clinical Trials. Eur J Cancer 2017;70:87-98. [CrossRef] google scholar
  • 5. Lenz HJ, Ou FS, Venook AP, Hochster HS, Niedzwiecki D, Goldberg RM, et al. Impact of Consensus Molecular Subtype on Survival in Patients With Metastatic Colorectal Cancer: Results From CALGB/SWOG 80405 (Alliance). J Clin Oncol 2019;37(22):1876-85. [CrossRef] google scholar
  • 6. Innocenti F, Fang-Shu Ou FS, Qu X, Zemla TJ, Niedzwiecki D, Tam R, et al. Mutational Analysis of Patients With Colorectal Cancer in CALGB/SWOG 80405 Identifies New Roles of Microsatellite Instability and Tumor Mutational Burden for Patient Outcome. J Clin Oncol 2019;37(14):1217-27. [CrossRef] google scholar
  • 7. Boeckx N, Koukakis R, Op de Beeck K, Rolfo C, Van Camp G, Siena S, et al. Effect of Primary Tumor Location on Second- Or Later-line Treatment Outcomes in Patients With RAS Wild-type Metastatic Colorectal Cancer and All Treatment Lines in Patients With RAS Mutations in Four Randomized Panitumumab Studies. Clin Colorectal Cancer 2018;17(3):170-8. [CrossRef] google scholar
  • 8. Bennouna J, Hiret S, Bertaut A, Bouche O , Deplanque G, Borel C, et al. Continuation of Bevacizumab vs Cetuximab Plus Chemotherapy After First Progression in KRAS Wild-Type Metastatic Colorectal Cancer: The UNICANCER PRODIGE18 Randomized Clinical Trial. JAMA Oncol 2019;5(1):83-90. [CrossRef] google scholar
  • 9. Cremolini C, Loupakis F, Antoniotti C, Lupi C, Sensi E, Lonardi S, et al. FOLFOXIRI Plus Bevacizumab Versus FOLFIRI Plus Bevacizumab as First-Line Treatment of Patients With Metastatic Colorectal Cancer: Updated Overall Survival and Molecular Subgroup Analyses of the Open-Label, Phase 3 TRIBE Study. Lancet Oncol 2015;16(13):1306-15. [CrossRef] google scholar
  • 10. Avallone A, Giuliani F. TRIBE2 results and toxicity. Lancet Oncol. 2020;21(6):e299. [CrossRef] google scholar
  • 11. Fornaro L, Lonardi S, Masi G, Loupakis F, Bergamo F, Salvatore L, et al. FOLFOXIRI in Combination With Panitumumab as First-Line Treatment in Quadruple Wild-Type (KRAS, NRAS, HRAS, BRAF) Metastatic Colorectal Cancer Patients: A Phase II Trial by the Gruppo Oncologico Nord Ovest (GONO). Ann Oncol2013;24(8):2062-7. [CrossRef] google scholar
  • 12. Borelli B, Moretto R, Lonardi S, Bonetti A, Antoniotti C, Pietrantonio, F et al. TRIPLETE: A Randomised Phase III Study of Modified FOLFOXIRI Plus Panitumumab Versus mFOLFOX6 Plus Panitumumab as Initial Therapy for Patients With Unresectable RAS and BRAF Wild-Type Metastatic Colorectal Cancer. ESMO Open 2018;3(4):e000403. [CrossRef] google scholar
  • 13. Pietrantonio F, Morano F, Corallo S, Miceli R, Lonardi S, Raimondi A, et al. Maintenance Therapy With Panitumumab Alone vs Panitumumab Plus Fluorouracil-Leucovorin in Patients With RAS Wild-Type Metastatic Colorectal CancerA Phase 2 Randomized Clinical Trial. JAMA Oncol 2019;5(9):1268-75. [CrossRef] google scholar
  • 14. Kopetz S, Grothey A, Van Cutsem E, Yaeger R, Wasan HS et 23. al. Encorafenib plus cetuximab with or without binimetinib for BRAF V600E metastatic colorectal cancer: Updated survival results from a randomized, three-arm, phase III study versus choice of either irinotecan or FOLFIRI plus cetuximab (BEACON CRC). J Clin Oncol 2020;38(15_ suppl): 4001-4001. [CrossRef] google scholar
  • 15. Sartore-Bianchi A, Trusolino L, Martino C, Bencardino K, Lonardi S, Bergamo F, et al. Dual-targeted therapy with trastuzumab and lapatinib in treatmentrefractory, KRAS codon 12/13 wild-type, HER2-positive metastatic colorectal cancer (HERACLES): a proof-ofconcept, multicentre, open-label, phase 2 trial. Lancet Oncol 2016;17(6):738-46. [CrossRef] google scholar
  • 16. Meric-Bernstam F, Hurwitz H, Raghav KPS, McWilliams RR, Fakih M, VanderWalde A, et al. Pertuzumab Plus Trastuzumab for HER2-amplified Metastatic Colorectal Cancer (MyPathway): An Updated Report From a Multicentre, Open-Label, Phase 2a, Multiple Basket Study. Lancet Oncol 2019;20(4):518-30. [CrossRef] google scholar
  • 17. Siena S, Di Bartolomeo M, Raghav KPS, Masuishi T, Loupakis F, et al. A phase II, multicenter, open-label study of trastuzumab deruxtecan (T-DXd; DS-8201) in patients (pts) with HER2-expressing metastatic colorectal cancer (mCRC): DESTINY-CRC01. J Clin Oncol 2020;38(15_ suppl):4000-4000. [CrossRef] google scholar
  • 18. Okamura R, Boichard A, Kato S, Sicklick JK, Bazhenova L, Kurzrock R. Analysis of NTRK Alterations in PanCancer Adult and Pediatric Malignancies: Implications for NTRK-Targeted Therapeutics. JCO Precis Oncol 2018;2018:10.1200/PO.18.00183. [CrossRef] google scholar
  • 19. Federman N, McDermott R. Larotrectinib, a highly selective tropomyosin receptor kinase (TRK) inhibitor for the treatment of TRK fusion cancer. Expert Rev Clin Pharmacol 2019;12(10):931-9. [CrossRef] google scholar
  • 20. Müller MF, Ibrahim AE, Arends MJ. Molecular Pathological Classification of Colorectal Cancer. Virchows Arch 2016;469(2):125-34. [CrossRef] google scholar
  • 21. Grothey A, Van Cutsem E, Sobrero A, Siena S, et al. Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): a,n international, multicentre, randomised, placebo-controlled, phase 3 trial. Lancet 2013;381(9863):303-12. [CrossRef] google scholar
  • 22. Mayer RJ, Van Cutsem E, Falcone A, Yoshino T, GarciaCarbonero R, Mizunuma N, et al. Randomized Trial of TAS102 for Refractory Metastatic Colorectal Cancer. N Engl J Med 2015;372:1909-19. [CrossRef] google scholar
  • 23. Karapeti CS , Khambata-Ford S, Jonker DJ, O’Callaghan CJ, Tu D, Tebbutt NC, et al. K-ras Mutations and Benefit From Cetuximab in Advanced Colorectal Cancer. N Engl J Med 2008;359(17):1757-65. [CrossRef] google scholar
  • 24. AmadoRG, Wolf M, Peeters M, Cutsem EV, Siena S, Freeman DJ, et al. Wild-type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer. JCO 2008;26(10):1626-34. [CrossRef] google scholar
  • 25. Masuishi T, Taniguchi H, Kawakami T, Kawamoto Y, Kadowaki S, Onozawa Y, et al. Impact of Tumour Growth Rate During Preceding Treatment on Tumour Response to Regorafenib or trifluridine/tipiracil in Refractory Metastatic Colorectal Cancer Esmo open 2019;4(6):e000584. [CrossRef] google scholar
  • 26. Pfeiffer P, Yilmaz M, Möller S, Zitnjak D, Krogh M, Petersen LN, et al. TAS-102 With or Without Bevacizumab in Patients With Chemorefractory Metastatic Colorectal Cancer: An Investigator-Initiated, Open-Label, Randomised, Phase 2 Trial. Lancet Oncol 2020;21(3):412-20. [CrossRef] google scholar
  • 27. Klein-Scory S, Maslova M, Pohl M, Eilert-Micus C, Schroers R, Schmiegel W, et al. Significance of Liquid Biopsy for Monitoring and Therapy Decision of Colorectal Cancer. Transl Oncol 2018;11(2):213-20. [CrossRef] google scholar
  • 28. Satake H, Sunakawa Y, MiyamotoY, Nakamura M, Nakayama H, Shiozawa M, et al. A Phase II Trial of 1st-line modifiedFOLFOXIRI Plus Bevacizumab Treatment for Metastatic Colorectal Cancer Harboring RAS Mutation: JACCRO CC11. Oncotarget 2018;9(27):18811-20. [CrossRef google scholar
  • 29. Diaz La, Dung TL,Won Kim T, et al. Pembrolizumab monotheraphy for patients with advanced MSI-H colorectal cancer: Longer-term follow up phase II. Keynote-164 study. 2020;38(15_suppl):4032-4032. [CrossRef] google scholar
  • 30. Lenz HJ, Lonardi S, Zagonel V, et al. Nivolumab (NIVO) + low dose ipilimumab (IPI) as after first-line (1L) therapy in microsatellite insitability-high/mismatch repair deficient (MSI-H/dMMR) metastatic colorectal cancer (mCRC): Two years clinical update. J Clin Oncol 2020;38(15_ suppl):4040-4040. [CrossRef] google scholar
  • 31. Thierry Andre, Kai-Keen Shiu, Won Kim T, Jensen BV, Jensen LH, Cornelis J. A et al. Pembrolizumab versus chemotherapy for microsatellite instability-high/mismatch repair deficient metastatic colorectal cancer: The phase 3 KEYNOTE-177 Study. J Clin Oncol 2020;38(18_suppl): LBA4- LBA4. [CrossRef] google scholar
  • 32. Jiang T, Chen X, Chunxia Su, Ren S, Zhou C. Pancancer analysis of ARID1A Alterations as Biomarkers for Immunotherapy Outcomes. J Cancer. 2020;11(4):776-780. [CrossRef] google scholar

Atıflar

Biçimlendirilmiş bir atıfı kopyalayıp yapıştırın veya seçtiğiniz biçimde dışa aktarmak için seçeneklerden birini kullanın


DIŞA AKTAR



APA

Karabulut, S., Karabulut, M., & Taştekin, D. (2021). METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi, 84(3), 425-429. https://doi.org/10.26650/IUITFD.2020.0086


AMA

Karabulut S, Karabulut M, Taştekin D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi. 2021;84(3):425-429. https://doi.org/10.26650/IUITFD.2020.0086


ABNT

Karabulut, S.; Karabulut, M.; Taştekin, D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi, [Publisher Location], v. 84, n. 3, p. 425-429, 2021.


Chicago: Author-Date Style

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. 2021. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi 84, no. 3: 425-429. https://doi.org/10.26650/IUITFD.2020.0086


Chicago: Humanities Style

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi 84, no. 3 (Nov. 2024): 425-429. https://doi.org/10.26650/IUITFD.2020.0086


Harvard: Australian Style

Karabulut, S & Karabulut, M & Taştekin, D 2021, 'METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER', İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 3, pp. 425-429, viewed 23 Nov. 2024, https://doi.org/10.26650/IUITFD.2020.0086


Harvard: Author-Date Style

Karabulut, S. and Karabulut, M. and Taştekin, D. (2021) ‘METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER’, İstanbul Tıp Fakültesi Dergisi, 84(3), pp. 425-429. https://doi.org/10.26650/IUITFD.2020.0086 (23 Nov. 2024).


MLA

Karabulut, Senem, and Mehmet Karabulut and Didem Taştekin. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER.” İstanbul Tıp Fakültesi Dergisi, vol. 84, no. 3, 2021, pp. 425-429. [Database Container], https://doi.org/10.26650/IUITFD.2020.0086


Vancouver

Karabulut S, Karabulut M, Taştekin D. METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER. İstanbul Tıp Fakültesi Dergisi [Internet]. 23 Nov. 2024 [cited 23 Nov. 2024];84(3):425-429. Available from: https://doi.org/10.26650/IUITFD.2020.0086 doi: 10.26650/IUITFD.2020.0086


ISNAD

Karabulut, Senem - Karabulut, Mehmet - Taştekin, Didem. “METASTATİK KOLON KANSERİ TEDAVİSİNDEKİ YENİLİKLER”. İstanbul Tıp Fakültesi Dergisi 84/3 (Nov. 2024): 425-429. https://doi.org/10.26650/IUITFD.2020.0086



ZAMAN ÇİZELGESİ


Gönderim13.07.2020
Kabul21.11.2020
Çevrimiçi Yayınlanma02.07.2021

LİSANS


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.