İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3  BİRİKİMİNİN ÖNEMİ

Oto Özgür; Dirim Ahmet; Şafak Seda; Güller Nurana; Demir Erol; Artan Ayşe Serra; Özlük Mesude; Uçar Ali; Soltanova Lala; Nuriyev Kanan; Yazıcı Halil; Kerem Çalışkan Yaşar

doi:https://dx.doi.org/10.26650/IUITFD.1126241

Araştırma Makalesi

DOI :10.26650/IUITFD.1126241 IUP :10.26650/IUITFD.1126241 Tam Metin (PDF)

İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ

Özgür Akın Oto, Şafak Mirioğlu, Ahmet Burak Dirim, Seda Şafak, Nurana Güller, Erol Demir, Ayşe Serra Artan, Mesude Yasemin Özlük, Ali Rıza Uçar, Lala Soltanova, Kanan Nuriyev, Halil Yazıcı, Yaşar Kerem Çalışkan

Amaç: Bu çalışmada, primer membranöz nefropatili (PMN) yaşlı (>60 yaş) hastalarda glomerüler C3 birikim yoğunluğunun klinik, histopatolojik özellikler ve hastalığın seyri üzerindeki etkilerini araştırmayı amaçladık. Gereç ve Yöntem: Bu retrospektif gözlemsel çalışmaya dahil ettiğimiz PMN’li 105 hastayı böbrek biyopsi örneklerinde C3 birikiminin yoğunluğuna göre düşük yoğunluklu (C3 1+; LI) ve yüksek yoğunluklu (C3 2+ veya C3 3+; HI) olmak üzere iki grupta inceledik. Birincil sonlanım noktası son evre böbrek hastalığı, ikincil sonlanım noktaları ise tam (CR) veya kısmi remisyon (PR) idi. Bulgular: İzlem sonunda (ortanca 30,6 ay), HI grubunda LI grubuna kıyasla daha fazla hasta birincil noktaya ulaşırken daha az hasta ikincil son noktalara erişti (sırasıyla p=0,015 ve p=0,016). Ayrıca HI grubunda LI grubuna göre glomerüler filtrasyon hızı (eGFR) daha düşük (p<0,001), proteinüri ise daha fazlaydı (p=0,018). Kaplan-Meier analizlerinde böbrek sağ kalımının (p=0,031) HI grubunda LI grubundan daha düşük olduğu saptandı. Çok değişkenli lojistik regresyon analizlerinde, son noktalar öngördürücü bir parametre saptanamadı. Sonuç: Yoğun glomerüler C3 birikimi, PMN’li yaşlı hastalarda olumsuz klinik sonuçlarla ilişkilidir.

Anahtar Kelimeler: Kompleman sistemi, C3, ileri yaş, membranöz nefropati

DOI :10.26650/IUITFD.1126241 IUP :10.26650/IUITFD.1126241 Tam Metin (PDF)

THE IMPORTANCE OF GLOMERULAR C3 ACCUMULATION IN ELDERLY PATIENTS WITH PRIMARY MEMBRANOUS NEPHROPATHY

Objective: The purpose of this study was to investigate the impact of glomerular C3 accumulation density on clinical, histopathological parameters and outcomes in elderly (>60 years) individuals with primary membranous nephropathy (PMN). Material and Methods: In this study, we examined the patients (n=105) in two groups according to the C3 staining density in kidney biopsy samples as low intensity (C3: 1+; LI group) and high intensity (C3: 2+ or C3: 3+; HI group). The primary endpoint of our study was the end-stage renal disease, and the secondary endpoints were the development of partial remission (PR) or complete remission (CR). Results: At the end of the follow-up (mean 30.6 months), more patients achieved the primary endpoint, and fewer patients achieved the secondary endpoints in the HI group compared to the LI group. (p=0.015 and p=0.016, respectively). Moreover, the glomerular filtration rate (eGFR) was lower (p<0.001), and proteinuria was higher in the HI group (p=0.018). Kaplan-Meier survival analysis revealed that renal survival (p=0.031) was lower in the HI group compared to the LI group. In the multivariate logistic regression analyses, no predictive parameters could be detected for the endpoints. Conclusion: Intense glomerular C3 deposition in elderly (>60 years) patients with PMN may be related to poor clinical outcomes.

Anahtar Kelimeler: Complementary system, C3, older age, membranous nephropathy

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DIŞA AKTAR

APA

Oto, Ö.A., Mirioğlu, Ş., Dirim, A.B., Şafak, S., Güller, N., Demir, E., Artan, A., Özlük, M.Y., Uçar, A.R., Soltanova, L., Nuriyev, K., Yazıcı, H., & Kerem Çalışkan, Y. (2022). İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ. İstanbul Tıp Fakültesi Dergisi, 85(4), 541-547. https://doi.org/10.26650/IUITFD.1126241

AMA

Oto Ö A, Mirioğlu Ş, Dirim A B, Şafak S, Güller N, Demir E, Artan A, Özlük M Y, Uçar A R, Soltanova L, Nuriyev K, Yazıcı H, Kerem Çalışkan Y. İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ. İstanbul Tıp Fakültesi Dergisi. 2022;85(4):541-547. https://doi.org/10.26650/IUITFD.1126241

ABNT

Oto, Ö.A.; Mirioğlu, Ş.; Dirim, A.B.; Şafak, S.; Güller, N.; Demir, E.; Artan, A.; Özlük, M.Y.; Uçar, A.R.; Soltanova, L.; Nuriyev, K.; Yazıcı, H.; Kerem Çalışkan, Y. İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ. İstanbul Tıp Fakültesi Dergisi, [Publisher Location], v. 85, n. 4, p. 541-547, 2022.

Chicago: Author-Date Style

Oto, Özgür Akın, and Şafak Mirioğlu and Ahmet Burak Dirim and Seda Şafak and Nurana Güller and Erol Demir and Ayşe Serra Artan and Mesude Yasemin Özlük and Ali Rıza Uçar and Lala Soltanova and Kanan Nuriyev and Halil Yazıcı and Yaşar Kerem Çalışkan. 2022. “İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ.” İstanbul Tıp Fakültesi Dergisi 85, no. 4: 541-547. https://doi.org/10.26650/IUITFD.1126241

Chicago: Humanities Style

Oto, Özgür Akın, and Şafak Mirioğlu and Ahmet Burak Dirim and Seda Şafak and Nurana Güller and Erol Demir and Ayşe Serra Artan and Mesude Yasemin Özlük and Ali Rıza Uçar and Lala Soltanova and Kanan Nuriyev and Halil Yazıcı and Yaşar Kerem Çalışkan. “İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ.” İstanbul Tıp Fakültesi Dergisi 85, no. 4 (Nov. 2024): 541-547. https://doi.org/10.26650/IUITFD.1126241

Harvard: Australian Style

Oto, ÖA & Mirioğlu, Ş & Dirim, AB & Şafak, S & Güller, N & Demir, E & Artan, A & Özlük, MY & Uçar, AR & Soltanova, L & Nuriyev, K & Yazıcı, H & Kerem Çalışkan, Y 2022, 'İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ', İstanbul Tıp Fakültesi Dergisi, vol. 85, no. 4, pp. 541-547, viewed 18 Nov. 2024, https://doi.org/10.26650/IUITFD.1126241

Harvard: Author-Date Style

Oto, Ö.A. and Mirioğlu, Ş. and Dirim, A.B. and Şafak, S. and Güller, N. and Demir, E. and Artan, A. and Özlük, M.Y. and Uçar, A.R. and Soltanova, L. and Nuriyev, K. and Yazıcı, H. and Kerem Çalışkan, Y. (2022) ‘İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ’, İstanbul Tıp Fakültesi Dergisi, 85(4), pp. 541-547. https://doi.org/10.26650/IUITFD.1126241 (18 Nov. 2024).

MLA

Oto, Özgür Akın, and Şafak Mirioğlu and Ahmet Burak Dirim and Seda Şafak and Nurana Güller and Erol Demir and Ayşe Serra Artan and Mesude Yasemin Özlük and Ali Rıza Uçar and Lala Soltanova and Kanan Nuriyev and Halil Yazıcı and Yaşar Kerem Çalışkan. “İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ.” İstanbul Tıp Fakültesi Dergisi, vol. 85, no. 4, 2022, pp. 541-547. [Database Container], https://doi.org/10.26650/IUITFD.1126241

Vancouver

Oto ÖA, Mirioğlu Ş, Dirim AB, Şafak S, Güller N, Demir E, Artan A, Özlük MY, Uçar AR, Soltanova L, Nuriyev K, Yazıcı H, Kerem Çalışkan Y. İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ. İstanbul Tıp Fakültesi Dergisi [Internet]. 18 Nov. 2024 [cited 18 Nov. 2024];85(4):541-547. Available from: https://doi.org/10.26650/IUITFD.1126241 doi: 10.26650/IUITFD.1126241

ISNAD

Oto, ÖzgürAkın - Mirioğlu, Şafak - Dirim, AhmetBurak - Şafak, Seda - Güller, Nurana - Demir, Erol - Artan, Ayşe Serra - Özlük, MesudeYasemin - Uçar, AliRıza - Soltanova, Lala - Nuriyev, Kanan - Yazıcı, Halil - Kerem Çalışkan, Yaşar. “İLERİ YAŞLI PRİMER MEMBRANÖZ NEFROPATİLİ HASTALARDA GLOMERÜLER C3 BİRİKİMİNİN ÖNEMİ”. İstanbul Tıp Fakültesi Dergisi 85/4 (Nov. 2024): 541-547. https://doi.org/10.26650/IUITFD.1126241

Cilt 85, Sayı 42022, S. 541-547

ZAMAN ÇİZELGESİ

Gönderim	05.06.2022
Kabul	05.07.2022
Çevrimiçi Yayınlanma	17.08.2022

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