Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells
Burçin İrem Abas, Ömer Erdoğan, Özge ÇevikObjective: Ovarian cancer has the highest mortality rate in women and it has a poor response rate to treatment due to its late diagnosis and is frequently resistant to currently used cisplatin-based treatment methods. Astragaloside IV (As-IV), a bioactive compound and natural tripeptide glycoside known as an antioxidant, has drawn attention in Chinese medicine for its healing properties. Many studies have shown that it has anti-inflammatory, antidiabetic, antitumoral, and anti-angiogenic properties.
Materials and Methods: In our study, we first rendered ovarian cancer cells (OVCAR-3) resistant to cisplatin and then applied determined doses of As-IV (40 μg/mL) and (70 μg/mL) to OVCAR-3 cells and cisplatin-resistant ovarian cancer cells (OVCAR-3- CisR). The cell viability capacity, variation of BAX/BCL-2 gene expression, and regulation of the SDF-1/CXCR4 chemokine axis protein and their gene expressions were investigated.
Results: According to the findings, As-IV administration suppressed metastasis by lowering the colony formation potential of cisplatin-resistant ovarian cancer and down-regulating the SDF-1/CXCR4 axis, and increasing the ratio of BAX/BCL-2 mRNA and protein levels due to BAX up-regulation and BCL-2 down-regulation.
Conclusion: As a result, we showed that As-IV, used as an antioxidant, can be used as an effective anticancer agent to improve response to the currently used cisplatin-based treatment in cases of drug resistance in ovarian cancer.
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APA
Abas, B.İ., Erdoğan, Ö., & Çevik, Ö. (2024). Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells. European Journal of Biology, 83(1), 1-9. https://doi.org/10.26650/EurJBiol.2024.1274734
AMA
Abas B İ, Erdoğan Ö, Çevik Ö. Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells. European Journal of Biology. 2024;83(1):1-9. https://doi.org/10.26650/EurJBiol.2024.1274734
ABNT
Abas, B.İ.; Erdoğan, Ö.; Çevik, Ö. Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells. European Journal of Biology, [Publisher Location], v. 83, n. 1, p. 1-9, 2024.
Chicago: Author-Date Style
Abas, Burçin İrem, and Ömer Erdoğan and Özge Çevik. 2024. “Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells.” European Journal of Biology 83, no. 1: 1-9. https://doi.org/10.26650/EurJBiol.2024.1274734
Chicago: Humanities Style
Abas, Burçin İrem, and Ömer Erdoğan and Özge Çevik. “Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells.” European Journal of Biology 83, no. 1 (Oct. 2024): 1-9. https://doi.org/10.26650/EurJBiol.2024.1274734
Harvard: Australian Style
Abas, Bİ & Erdoğan, Ö & Çevik, Ö 2024, 'Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells', European Journal of Biology, vol. 83, no. 1, pp. 1-9, viewed 11 Oct. 2024, https://doi.org/10.26650/EurJBiol.2024.1274734
Harvard: Author-Date Style
Abas, B.İ. and Erdoğan, Ö. and Çevik, Ö. (2024) ‘Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells’, European Journal of Biology, 83(1), pp. 1-9. https://doi.org/10.26650/EurJBiol.2024.1274734 (11 Oct. 2024).
MLA
Abas, Burçin İrem, and Ömer Erdoğan and Özge Çevik. “Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells.” European Journal of Biology, vol. 83, no. 1, 2024, pp. 1-9. [Database Container], https://doi.org/10.26650/EurJBiol.2024.1274734
Vancouver
Abas Bİ, Erdoğan Ö, Çevik Ö. Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells. European Journal of Biology [Internet]. 11 Oct. 2024 [cited 11 Oct. 2024];83(1):1-9. Available from: https://doi.org/10.26650/EurJBiol.2024.1274734 doi: 10.26650/EurJBiol.2024.1274734
ISNAD
Abas, Burçinİrem - Erdoğan, Ömer - Çevik, Özge. “Astragaloside-IV Inhibits Metastasis by Suppressing the SDF-1/CXCR4 Axis and Activating Apoptosis in Cisplatin-Resistant Ovarian Cancer Cells”. European Journal of Biology 83/1 (Oct. 2024): 1-9. https://doi.org/10.26650/EurJBiol.2024.1274734