Research Article


DOI :10.26650/eor.20231086355   IUP :10.26650/eor.20231086355    Full Text (PDF)

Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase

Pınar GülÖzcan KarataşÖmer SağsözSeda AşkınÖzge TürkeriAhmet Kızıltunç

Purpose This study aims at determining the amount of mercury released over time from amalgam after treatment in healthy subjects and to examine the relation of mercury with serum MT-1 and SOD-1 levels. Materials and Methods Amalgam filling was applied to the 15 subjects aged 19-22 years and blood samples were collected before treatment and 1 day, 7 days, 21 days and 35 days after treatment. Mercury analysis of serum samples was performed using Inductively Coupled Plasma Mass Spectrometry (ICP-MS). In addition, MT-1 and SOD-1 levels in serum samples were measured using commercial enzyme-linked immunosorbent assay (ELISA). Friedman test and Spearman’s correlation analysis was performed to analyse the data. p value was interpreted in significance level of 0.05. Results As a result of the analysis for MT-1, it was found that the values decreased over time and this decrease was statistically significant after 21 days (p<0.05). In addition, it was found that SOD-1 decreased over time, but this decrease was not statistically significant . In terms of released mercury, there was no statistically significant difference among the values of mercury released over time . According to the results of correlation analysis, no statistically significant relationship was found among the variables. Conclusion The results of the present study indicated that the amount of mercury released from the tested amalgam were found to be tolerable and no significant relationship was found between MT-1 and SOD-1.

DOI :10.26650/eor.20231086355   IUP :10.26650/eor.20231086355    Full Text (PDF)

Amalgam dolgudan civa salımı ve civanın metallotionein ve süperoksit dismutaz ile ilişkisi

Pınar GülÖzcan KarataşÖmer SağsözSeda AşkınÖzge TürkeriAhmet Kızıltunç

Amaç: Bu çalışmada, sağlıklı bireylerde tedavi sonrası amalgamdan zamanla salınan civa miktarının belirlenmesi ve civanın serum MT-1 ve SOD-1 düzeyleri ile ilişkisinin incelenmesi amaçlanmıştır. Gereç ve Yöntem: Yaşları 19-22 arasında değişen 15 deneğe amalgam dolgu uygulandı ve tedavi öncesi ve tedaviden 1 gün, 7 gün, 21 gün ve 35 gün sonra kan örnekleri alındı. Serum numunelerinin civa analizi, İndüktif Olarak Eşleştirilmiş Plazma Kütle Spektrometresi (ICPMS) kullanılarak yapıldı. Ek olarak, serum numunelerindeki MT-1 ve SOD-1 seviyeleri ticari ELISA kitleri kullanılarak ölçüldü. Elde edilen verilerin analizi Friedman testi ve Spearman korelasyon analizi kullanılarak yapıldı. p<0,05 değeri istatistiksel olarak anlamlılık düzeyinde yorumlanmıştır. Bulgular: MT-1 için yapılan analiz sonucunda değerlerin zamanla azaldığı ve bu düşüşün 21 gün sonra istatistiksel olarak anlamlı olduğu bulundu. Ayrıca SOD-1'in zamanla azaldığı ancak bu düşüşün istatistiksel olarak anlamlı olmadığı bulundu (p>0,05). Salınan civa miktarı açısından zamanla salınan civa değerleri arasında istatistiksel olarak anlamlı bir fark bulunmadı. Korelasyon analizi sonuçlarına göre değişkenler arasında istatistiksel olarak anlamlı bir ilişki bulunmadı. Sonuç: Bu çalışmanın sonuçları, test edilen amalgamdan salınan civa miktarının tolere edilebilir olduğunu ve MT-1 ile SOD-1 arasında anlamlı bir ilişki bulunmadığını göstermiştir.


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APA

Gül, P., Karataş, Ö., Sağsöz, Ö., Aşkın, S., Türkeri, Ö., & Kızıltunç, A. (2019). Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase. European Oral Research, 0(0), -. https://doi.org/10.26650/eor.20231086355


AMA

Gül P, Karataş Ö, Sağsöz Ö, Aşkın S, Türkeri Ö, Kızıltunç A. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase. European Oral Research. 2019;0(0):-. https://doi.org/10.26650/eor.20231086355


ABNT

Gül, P.; Karataş, Ö.; Sağsöz, Ö.; Aşkın, S.; Türkeri, Ö.; Kızıltunç, A. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase. European Oral Research, [Publisher Location], v. 0, n. 0, p. -, 2019.


Chicago: Author-Date Style

Gül, Pınar, and Özcan Karataş and Ömer Sağsöz and Seda Aşkın and Özge Türkeri and Ahmet Kızıltunç. 2019. “Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase.” European Oral Research 0, no. 0: -. https://doi.org/10.26650/eor.20231086355


Chicago: Humanities Style

Gül, Pınar, and Özcan Karataş and Ömer Sağsöz and Seda Aşkın and Özge Türkeri and Ahmet Kızıltunç. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase.” European Oral Research 0, no. 0 (Oct. 2022): -. https://doi.org/10.26650/eor.20231086355


Harvard: Australian Style

Gül, P & Karataş, Ö & Sağsöz, Ö & Aşkın, S & Türkeri, Ö & Kızıltunç, A 2019, 'Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase', European Oral Research, vol. 0, no. 0, pp. -, viewed 5 Oct. 2022, https://doi.org/10.26650/eor.20231086355


Harvard: Author-Date Style

Gül, P. and Karataş, Ö. and Sağsöz, Ö. and Aşkın, S. and Türkeri, Ö. and Kızıltunç, A. (2019) ‘Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase’, European Oral Research, 0(0), pp. -. https://doi.org/10.26650/eor.20231086355 (5 Oct. 2022).


MLA

Gül, Pınar, and Özcan Karataş and Ömer Sağsöz and Seda Aşkın and Özge Türkeri and Ahmet Kızıltunç. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase.” European Oral Research, vol. 0, no. 0, 2019, pp. -. [Database Container], https://doi.org/10.26650/eor.20231086355


Vancouver

Gül P, Karataş Ö, Sağsöz Ö, Aşkın S, Türkeri Ö, Kızıltunç A. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase. European Oral Research [Internet]. 5 Oct. 2022 [cited 5 Oct. 2022];0(0):-. Available from: https://doi.org/10.26650/eor.20231086355 doi: 10.26650/eor.20231086355


ISNAD

Gül, Pınar - Karataş, Özcan - Sağsöz, Ömer - Aşkın, Seda - Türkeri, Özge - Kızıltunç, Ahmet. Release of mercury from amalgam filling and its relationship with metallothionein and superoxide dismutase”. European Oral Research 0/0 (Oct. 2022): -. https://doi.org/10.26650/eor.20231086355



TIMELINE


Submitted11.03.2022
Accepted07.05.2022
Published Online05.09.2022

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