Research Article


DOI :10.26650/eor.20190041   IUP :10.26650/eor.20190041    Full Text (PDF)

The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis

Erman SenelEnes ÖzkanMehmet Cihan BereketMehmet Emin Önger

Purpose 
This study aims to evaluate the effects of extracorporeal shock wave therapy applied before and/or immediately after the osteotomy on the maturation during the consolidation phase. 

Materials and Methods 
21 female New Zealand rabbits were used in the study. Subjects were divided randomly into three groups: Control (Distraction without ESWT), A (Distraction +ESWT After Osteotomy), AB (Distraction+ESWT After and Before Osteotomy). ESWT (500 pulses, 5 Hz, 0.19 mJ/mm2 energy flux density) was applied to group A and group AB after 5, 12 and 19 days after osteotomy and group AB only on days 7,14 and 21 before osteotomy. On the 28th day of the consolidation period, all subjects were sacrificed. Dual-energy x-ray absorptiometry (DEXA) was used to determine bone mineral density (BMD) and bone mineral content (BMC), and stereological methods were used to determine the new bone, connective tissue and neovascularization volumes. 

Results 
As a result of DEXA examinations made on the 1st and 4th week of consolidation, there was no significant difference between groups regarding BMD and BMC values. According to the results of stereological examination, when the connective tissue and new bone tissue were evaluated, higher values were observed in AB when compared to A, and in AB and A compared to the control group, but the differences are not statistically significant. There was no difference between the groups in terms of neovascularization. 

Conclusion 
ESWT in these parameters was not positively effective in bone maturation during consolidation when applied before osteotomy or both before and after osteotomy. 

PDF View

References

  • 1. Raza H, Saltaji H, Kaur H, Flores-Mir C, El-Bialy T. Effect of LowIntensity Pulsed Ultrasound on Distraction Osteogenesis Treatment Time: A Meta-analysis of Randomized Clinical Trials. J Ultrasound Med 2016;35(2):349-358. [CrossRef] google scholar
  • 2. Zimmermann C, Thurmuller M, Troulis D, Perrott B, Rahn L, Kaban B. Histology of the porcine mandibular distraction wound. Int J Oral Maxillofac Surg 2005;34(4), 411-419. [CrossRef] google scholar
  • 3. Jiang X, Zhang Y, Fan X, Deng X, Zhu Y, Li F. The effects of hypoxiainducible factor (HIF)-1α protein on bone regeneration during distraction osteogenesis: an animal study. Int J Oral Maxillofac Surg 2016;45(2):267-272. [CrossRef] google scholar
  • 4. Freddo AL, Giongo CC, Ponzoni D, Corsetti A, Puricelli E. Influence of a Magnetic Field and Laser Therapy on the Quality of Mandibular Bone During Distraction Osteogenesis in Rabbits. J Oral Maxillofac Surg 2016;74(11):2287.e1-2287.e8. [CrossRef] google scholar
  • 5. Williams PR, Smith NC, Cooke-Yarborough C, Little DG. Bisphosphonates and nephrocalcinosis in a rabbit leg lengthening model: a histological and therapeutic comparison. Pharmacol Toxicol 2001;89:149-152. [CrossRef] google scholar
  • 6. Primrose AC, Broadfoot E, Diner PA, Molina F, Moos KF, Ayoub AF. Patients' responses to distraction osteogenesis: a multi-centre study. Int J Oral Maxillofac Surg 2005;34(3):238-242. [CrossRef] google scholar
  • 7. Zhu S, Song D, Jiang X, Zhou H, Hu J. Combined effects of recombinant human BMP-2 and Nell-1 on bone regeneration in rapid distraction osteogenesis of rabbit tibia. Injury 2011;42(12):1467-1473. [CrossRef] google scholar
  • 8. Yonezawa H, Harada K, Ikebe T, Shinohara M, Enomoto S. Effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) on bone consolidation on distraction osteogenesis: a preliminary study in rabbit mandibles. J Craniomaxillofac Surg 2006;34(5):270-276. [CrossRef] google scholar
  • 9. Castro-Govea Y, Cervantes-Kardasch VH, Borrego-Soto G, Martínez-Rodríguez HG, Espinoza-Juarez M, Romero-Díaz V, Marino-Martínez IA, Robles-Zamora A, Álvarez-Lozano E, PadillaRivas GR, Ortiz-López R, Lara-Arias J, google scholar
  • Martínez A. Human bone morphogenetic protein 2-transduced mesenchymal stem cells improve bone regeneration in a model of mandible distraction surgery. J Craniofac Surg 2012;23(2):392396. [CrossRef] google scholar
  • 10. Alp YE, Taskaldiran A, Onder ME, Karahan S, Kocyigit ID, Atil F, Tekin U. Effects of Local Low-Dose Alendronate Injections Into the Distraction Gap on New Bone Formation and Distraction Rate on Distraction Osteogenesis. J Craniofac Surg 2017;28(8):21742178. [CrossRef] google scholar
  • 11. Taylor BA, Bezuhly M, Brace M, Carter M, Hong P. Effect of strontium citrate on bone consolidation during mandibular distraction osteogenesis. Laryngoscope 2017;127(7):e212-e218. [CrossRef] google scholar
  • 12. Onger ME, Bereket C, Sener I, Ozkan N, Senel E, Polat AV. Is it possible to change of the duration of consolidation period in the distraction osteogenesis with the repetition of extracorporeal shock waves? Med Oral Patol Oral Cir Bucal 2017;22(2):e251-e257. [CrossRef] google scholar
  • 13. Martini L, Giavaresi G, Fini M, Torricelli P, de Pretto M, Schaden W, Giardino R. Effect of extracorporeal shock wave therapy on osteoblastlike cells. Clin Orthop Relat Res 2003;413:269-280. [CrossRef] google scholar
  • 14. Huang HM, Li XL, Tu SQ, Chen XF, Lu CC, Jiang LH. Effects of roughly focused extracorporeal shock waves therapy on the expressions of bone morphogenetic protein-2 and osteoprotegerin in osteoporotic fracture in rats. Chin Med J (Engl) 2016;129(21):2567-2575. [CrossRef] google scholar
  • 15. Wang FS, Yang KD, Kuo YR, Wang CJ, Sheen-Chen SM, Huang HC, Chen YJ. Temporal and spatial expression of bone morphogenetic proteins in extracorporeal shock wave-promoted healing of segmental defect. Bone 2003;32:387-396. [CrossRef] google scholar
  • 16. Wang CJ, Wang FS, Yang KD. Biological Effects of Extracorporeal Shockwave in Bone Healing: A Study in Rabbits, Arch Orthop Trauma Surg 2008;128:879-884. [CrossRef] google scholar
  • 17. Lai JP, Wang FS, Hung CM, Wang CJ, Huang CJ, Kuo YR. Extracorporeal shock wave accelerates consolidation in distraction osteogenesis of the rat mandible. J Trauma 2010;69(5):1252-1258. [CrossRef] google scholar
  • 18. Şahin B, Emirzeoglu M, Uzun A, İncesu L, Bek Y, Bilgiç S, Kaplan S. Unbiased estimation of the liver volume by the Cavalieri principle using magnetic resonance images. Eur J Radiol 2003;47:164-170. [CrossRef] google scholar
  • 19. Bulut O, Eroglu M, Ozturk H, Tezeren G, Bulut S, Koptagel E. Extracorporeal shock wave treatment for defective nonunion of the radius: a rabbit model. J Orthop Surg 2006;14(2):133-137. [CrossRef] google scholar
  • 20. Potres Z, Deshpande S, Klöeppel H, Voss K, Klineberg I. Assisted wound healing and vertical bone regeneration with simultaneous implant placement: a histologic pilot study. Int J Oral Maxillofac Implants 2016;31(1):45-54. [CrossRef] google scholar
  • 21. van der Jagt OP, Piscaer TM, Schaden W, Li J, Kops N, Jahr H, van der Linden JC, Waarsing JH, Verhaar JA, de Jong M, Weinans H. Unfocused extracorporeal shock waves induce anabolic effects in rat bone. J Bone Joint Surg Am 2011;93(1):38-48. [CrossRef] google scholar
  • 22. Kearney CJ, Hsu HP, Spector M. The use of extracorporeal shock wave-stimulated periosteal cells for orthotopic bone generation. Tissue Eng Part A 2012;18(13-14):1500-1508. [CrossRef] google scholar
  • 23. Ma D, Ren L, Yao H, Tian W, Chen F, Zhang J, Liu Y, Mao T. Locally injection of cell sheet fragments enhances new bone formation in mandibular distraction osteogenesis: a rabbit model. J Orthop Res 2013;31(7):1082-1088. [CrossRef] google scholar
  • 24. van der Jagt OP, van der Linden JC, Schaden W, van Schie HT, Piscaer TM, Verhaar JA, Weinans H, Waarsing JH. Unfocused extracorporeal shock wave therapy as potential treatment for osteoporosis. J Orthop Res 2009;27(11):1528-1533. [CrossRef] google scholar
  • 25. Çakir-Özkan N, Bereket C, Arici N, Elmali M, Şener I, Bekar E. The radiological and stereological analysis of the effect of low-level laser therapy on the mandibular midline distraction osteogenesis. J Craniofac Surg 2015;26(7):e595-599. [CrossRef] google scholar
  • 26. Wang FS, Yang KD, Wang CJ, Huang HC, Chio CC, Hsu TY, Ou CY. Shockwave stimulates oxygen radical-mediated osteogenesis of the mesenchymal cells from human umbilical cord blood. J Bone Miner Res 2004;19(6):973-982. [CrossRef] google scholar
  • 27. Özkan E, Bereket MC, Önger ME, Polat AV. The Effect of Unfocused Extracorporeal Shock Wave Therapy on Bone Defect Healing in Diabetics. J Craniofac Surg 2018;29(4):1081-1086. [CrossRef] google scholar
  • 28. Ding Y, Li G, Ao J, Zhou L, Ma Q, Liu Y. 99mTechnetium-methylene diphosphonate bone imaging using low-intensity pulsed ultrasound: promotion of bone formation during mandibular distraction osteogenesis in dogs. Br J Oral Maxillofac Surg 2010;48:94-99. [CrossRef] google scholar
  • 29. Cerqueira A, Silveira RL, Oliveira MG, Sant'ana Filho M, Heitz C. Bone tissue microscopic findings related to the use of diode laser (830 nm) in ovine mandible submitted to distraction osteogenesis. Acta Cir Bras 2007;22(2):92-97. [CrossRef] google scholar
  • 30. Freddo AL, Hübler R, de Castro-Beck CA, Heitz C, de Oliveira MG. A preliminary study of hardness and modulus of elasticity in sheep mandibles submitted to distraction osteogenesis and low-level laser therapy. Med Oral Patol Oral Cir Bucal 2012;17(1):e102-107. [CrossRef] google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Senel, E., Özkan, E., Bereket, M.C., & Önger, M.E. (2019). The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis. European Oral Research, 53(3), 125-131. https://doi.org/10.26650/eor.20190041


AMA

Senel E, Özkan E, Bereket M C, Önger M E. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis. European Oral Research. 2019;53(3):125-131. https://doi.org/10.26650/eor.20190041


ABNT

Senel, E.; Özkan, E.; Bereket, M.C.; Önger, M.E. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis. European Oral Research, [Publisher Location], v. 53, n. 3, p. 125-131, 2019.


Chicago: Author-Date Style

Senel, Erman, and Enes Özkan and Mehmet Cihan Bereket and Mehmet Emin Önger. 2019. “The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis.” European Oral Research 53, no. 3: 125-131. https://doi.org/10.26650/eor.20190041


Chicago: Humanities Style

Senel, Erman, and Enes Özkan and Mehmet Cihan Bereket and Mehmet Emin Önger. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis.” European Oral Research 53, no. 3 (Feb. 2023): 125-131. https://doi.org/10.26650/eor.20190041


Harvard: Australian Style

Senel, E & Özkan, E & Bereket, MC & Önger, ME 2019, 'The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis', European Oral Research, vol. 53, no. 3, pp. 125-131, viewed 1 Feb. 2023, https://doi.org/10.26650/eor.20190041


Harvard: Author-Date Style

Senel, E. and Özkan, E. and Bereket, M.C. and Önger, M.E. (2019) ‘The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis’, European Oral Research, 53(3), pp. 125-131. https://doi.org/10.26650/eor.20190041 (1 Feb. 2023).


MLA

Senel, Erman, and Enes Özkan and Mehmet Cihan Bereket and Mehmet Emin Önger. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis.” European Oral Research, vol. 53, no. 3, 2019, pp. 125-131. [Database Container], https://doi.org/10.26650/eor.20190041


Vancouver

Senel E, Özkan E, Bereket MC, Önger ME. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis. European Oral Research [Internet]. 1 Feb. 2023 [cited 1 Feb. 2023];53(3):125-131. Available from: https://doi.org/10.26650/eor.20190041 doi: 10.26650/eor.20190041


ISNAD

Senel, Erman - Özkan, Enes - Bereket, MehmetCihan - Önger, MehmetEmin. The assessment of new bone formation induced by unfocused extracorporeal shock wave therapy applied on pre-surgical phase of distraction osteogenesis”. European Oral Research 53/3 (Feb. 2023): 125-131. https://doi.org/10.26650/eor.20190041



TIMELINE


Submitted20.09.2018
Accepted08.02.2019
Published Online10.09.2019

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE




Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.