Research Article


DOI :10.26650/experimed.1299445   IUP :10.26650/experimed.1299445    Full Text (PDF)

Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019

Dilay KarabulutCennet YıldızUmut KarabulutErsan OflarFatma Nihan Turhan ÇağlarKadriye Kart YaşarGülçin Şahingöz ErdalOsman PirhanPınar KasapoğluNilgün Işıksaçan

Objective: This study aimed to evaluate cardiac myosin-binding protein C (cMyBP-C) levels in patients with COVID-19.

Materials and Methods: Overall, 187 patients were enrolled in the study. Patients with mild–moderate and severe–critical illness constituted groups 0 and 1, respectively.

Results: Admission to the intensive care unit and hospitalization period were significantly higher in group 1. Hemoglobin levels, lymphocyte count, and albumin levels were significantly lower, and lactate dehydrogenase, C-reactive protein (CRP), D-dimer, cardiac troponin I (cTnI), and procalcitonin levels, prothrombin time (PT), and CRP/lymphocyte ratio were higher in group 1 patients compared to group 0 patients. cTnI and CRP/lymphocyte ratio were higher, and ferritin/procalcitonin and albumin/CRP ratios were lower in deceased patients than in surviving patients, while MyBP-C levels were similar in the two groups. Multivariate regression analysis revealed that lymphocyte count and urea levels were independent predictors of mortality. Receiver Operating Characteristic (ROC) curve analysis showed that cTnI level and ferritin/procalcitonin, CRP/lymphocyte, and albumin/CRP ratios were valuable biochemical parameters for predicting mortality in patients with COVID-19.

Conclusion: cMyBP-C level may not be a valuable tool for predicting the severity or prognosis of COVID-19.


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APA

Karabulut, D., Yıldız, C., Karabulut, U., Oflar, E., Turhan Çağlar, F.N., Kart Yaşar, K., Şahingöz Erdal, G., Pirhan, O., Kasapoğlu, P., & Işıksaçan, N. (2023). Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019. Experimed, 13(3), 180-186. https://doi.org/10.26650/experimed.1299445


AMA

Karabulut D, Yıldız C, Karabulut U, Oflar E, Turhan Çağlar F N, Kart Yaşar K, Şahingöz Erdal G, Pirhan O, Kasapoğlu P, Işıksaçan N. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019. Experimed. 2023;13(3):180-186. https://doi.org/10.26650/experimed.1299445


ABNT

Karabulut, D.; Yıldız, C.; Karabulut, U.; Oflar, E.; Turhan Çağlar, F.N.; Kart Yaşar, K.; Şahingöz Erdal, G.; Pirhan, O.; Kasapoğlu, P.; Işıksaçan, N. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019. Experimed, [Publisher Location], v. 13, n. 3, p. 180-186, 2023.


Chicago: Author-Date Style

Karabulut, Dilay, and Cennet Yıldız and Umut Karabulut and Ersan Oflar and Fatma Nihan Turhan Çağlar and Kadriye Kart Yaşar and Gülçin Şahingöz Erdal and Osman Pirhan and Pınar Kasapoğlu and Nilgün Işıksaçan. 2023. “Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019.” Experimed 13, no. 3: 180-186. https://doi.org/10.26650/experimed.1299445


Chicago: Humanities Style

Karabulut, Dilay, and Cennet Yıldız and Umut Karabulut and Ersan Oflar and Fatma Nihan Turhan Çağlar and Kadriye Kart Yaşar and Gülçin Şahingöz Erdal and Osman Pirhan and Pınar Kasapoğlu and Nilgün Işıksaçan. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019.” Experimed 13, no. 3 (Mar. 2024): 180-186. https://doi.org/10.26650/experimed.1299445


Harvard: Australian Style

Karabulut, D & Yıldız, C & Karabulut, U & Oflar, E & Turhan Çağlar, FN & Kart Yaşar, K & Şahingöz Erdal, G & Pirhan, O & Kasapoğlu, P & Işıksaçan, N 2023, 'Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019', Experimed, vol. 13, no. 3, pp. 180-186, viewed 3 Mar. 2024, https://doi.org/10.26650/experimed.1299445


Harvard: Author-Date Style

Karabulut, D. and Yıldız, C. and Karabulut, U. and Oflar, E. and Turhan Çağlar, F.N. and Kart Yaşar, K. and Şahingöz Erdal, G. and Pirhan, O. and Kasapoğlu, P. and Işıksaçan, N. (2023) ‘Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019’, Experimed, 13(3), pp. 180-186. https://doi.org/10.26650/experimed.1299445 (3 Mar. 2024).


MLA

Karabulut, Dilay, and Cennet Yıldız and Umut Karabulut and Ersan Oflar and Fatma Nihan Turhan Çağlar and Kadriye Kart Yaşar and Gülçin Şahingöz Erdal and Osman Pirhan and Pınar Kasapoğlu and Nilgün Işıksaçan. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019.” Experimed, vol. 13, no. 3, 2023, pp. 180-186. [Database Container], https://doi.org/10.26650/experimed.1299445


Vancouver

Karabulut D, Yıldız C, Karabulut U, Oflar E, Turhan Çağlar FN, Kart Yaşar K, Şahingöz Erdal G, Pirhan O, Kasapoğlu P, Işıksaçan N. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019. Experimed [Internet]. 3 Mar. 2024 [cited 3 Mar. 2024];13(3):180-186. Available from: https://doi.org/10.26650/experimed.1299445 doi: 10.26650/experimed.1299445


ISNAD

Karabulut, Dilay - Yıldız, Cennet - Karabulut, Umut - Oflar, Ersan - Turhan Çağlar, FatmaNihan - Kart Yaşar, Kadriye - Şahingöz Erdal, Gülçin - Pirhan, Osman - Kasapoğlu, Pınar - Işıksaçan, Nilgün. Assessment of Cardiac Myosin-binding Protein C Levels in Coronavirus Disease 2019”. Experimed 13/3 (Mar. 2024): 180-186. https://doi.org/10.26650/experimed.1299445



TIMELINE


Submitted19.05.2023
Accepted16.10.2023
Published Online28.12.2023

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