Caspase-9 rs1052576 Polymorphism is not Associated with Glioblastoma in Turkish PatientsDeryanaz Billur, Fatma Tuba Akdeniz, Seda Güleç Yılmaz, Zerrin Barut, Cumhur Kaan Yaltırık, Turgay İsbir
Objective: As an aggressive type of brain cancer, glioblastoma remains obscure with its short survival time and unclear molecular architecture. Single nucleotide polymorphisms (SNPs), such as those located in the regions of the caspase-9 gene (CASP9), have been reported to be associated with genetic susceptibility to glioblastoma. There is no exact result on the effect of CASP9 SNP rs1052576 on glioblastoma and its biomarker candidacy for the Turkish population. Investigating the polymorphism of the exon 5 (+32 G/A) region of the CASP9 in glioblastoma patients in the Turkish population was the aim of this study. Materials and Methods: Real-time polymerase chain reaction (RT-PCR) method on blood samples of glioblastoma patients (n=33) and healthy controls (n=35) were used to analyze CASP9 SNP rs1052576. Statistical data were obtained using SPSS v.23 software. Results: For CASP9 rs1052576, no evidence was found of its role in glioblastoma (p=0.594). Conclusion: This study was designed to determine the association between glioblastoma and CASP9 SNP rs1052576 within the Turkish population. Our results indicated that CASP9 SNP rs1052576 is not related to glioblastoma in Turkish patients. To clarify these results, further studies with a larger sample size are needed.