Research Article


DOI :10.26650/experimed.1285692   IUP :10.26650/experimed.1285692    Full Text (PDF)

Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells

Dilşad Özerkanİshak Afşin Kariper

Objective: Colorectal cancers pose a major threat along with increasing morbidity and mortality to human health worldwide. Therefore, it is crucial to develop effective and safe methods for tumor therapy. In recent years, nanoparticles have emerged as successful candidates for drug delivery into tumor tissue. The particle size of nanoparticles (NPs) is of great importance for passive tumor targeting. Therefore, in this study, we aimed to synthesize and characterize rubidium-based nanoparticles (RbNPs) from the moss Abietinella abietina (AA) and determine their anticancer effects on colorectal carcinoma cell line (HCT116).

Materials and Methods: A field emission scanning electron microscope (FESEM), dynamic light scattering (DLS), energy dispersive X-ray analysis (EDX), UV/VIS and fourier transform infrared (FTIR) spectrophotometers were used to characterize the RbNPs. To study the cytotoxicity, a sulforhodamine B (SRB) assay was performed in colorectal carcinoma cell cultures.

Results: As a result, RbNPs- AA developed with an average particle size of about 70 nm. RbNPs- AA proved to be cytotoxic at lower doses than free AA, as it decreased cell viability at half the amount of free AA (14.25 µg/mL).

Conclusion: The availability of RbNPs, particularly for the treatment of colorectal cancer, is evidenced by the fact that all the data collected are highly relevant.


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APA

Özerkan, D., & Kariper, İ.A. (2023). Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells. Experimed, 13(2), 97-102. https://doi.org/10.26650/experimed.1285692


AMA

Özerkan D, Kariper İ A. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells. Experimed. 2023;13(2):97-102. https://doi.org/10.26650/experimed.1285692


ABNT

Özerkan, D.; Kariper, İ.A. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells. Experimed, [Publisher Location], v. 13, n. 2, p. 97-102, 2023.


Chicago: Author-Date Style

Özerkan, Dilşad, and İshak Afşin Kariper. 2023. “Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells.” Experimed 13, no. 2: 97-102. https://doi.org/10.26650/experimed.1285692


Chicago: Humanities Style

Özerkan, Dilşad, and İshak Afşin Kariper. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells.” Experimed 13, no. 2 (Jul. 2024): 97-102. https://doi.org/10.26650/experimed.1285692


Harvard: Australian Style

Özerkan, D & Kariper, İA 2023, 'Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells', Experimed, vol. 13, no. 2, pp. 97-102, viewed 20 Jul. 2024, https://doi.org/10.26650/experimed.1285692


Harvard: Author-Date Style

Özerkan, D. and Kariper, İ.A. (2023) ‘Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells’, Experimed, 13(2), pp. 97-102. https://doi.org/10.26650/experimed.1285692 (20 Jul. 2024).


MLA

Özerkan, Dilşad, and İshak Afşin Kariper. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells.” Experimed, vol. 13, no. 2, 2023, pp. 97-102. [Database Container], https://doi.org/10.26650/experimed.1285692


Vancouver

Özerkan D, Kariper İA. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells. Experimed [Internet]. 20 Jul. 2024 [cited 20 Jul. 2024];13(2):97-102. Available from: https://doi.org/10.26650/experimed.1285692 doi: 10.26650/experimed.1285692


ISNAD

Özerkan, Dilşad - Kariper, İshakAfşin. Characterization of Rubidium-Based Nanoparticles by Green Synthesis and Their Effect on Colorectal Cancer Cells”. Experimed 13/2 (Jul. 2024): 97-102. https://doi.org/10.26650/experimed.1285692



TIMELINE


Submitted19.04.2023
Accepted14.06.2023
Published Online28.07.2023

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