Research Article


DOI :10.26650/experimed.1383105   IUP :10.26650/experimed.1383105    Full Text (PDF)

Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study

Nuri Barış HasbalMutlu Arat

Objective: This study aimed to conduct a retrospective evaluation of clinical findings on patients undergoing autologous hematopoietic stem cell transplantation.

Materials and Methods: A total of 167 consecutive patients who were diagnosed with multiple myeloma (MM) and lymphoma and then underwent autologous hematopoietic stem cell transplantation (AHSCT) between August 2010 and May 2013 were included in our study. Demographic, disease, mobilization, apheresis, and transplantation data were reviewed from patient files.

Results: In 121 patients (72%), mobilization was achieved solely with granulocyte colony stimulating factor (G-CSF). There was no relationship between peripheral CD34+ cell count and age, disease type, or previous treatment features. The total CD34+ cell count postapheresis was 3.3 ± 3.1 × 106 /kg. Only nine patients could not achieve successful mobilization with any regimen. The median day of neutrophil and platelet engraftment among the entire patient group was 11 days. As the number of CD34+ cells infused into patients increased, neutrophil and platelet engraftment time decreased.

Conclusion: Mobilization was achieved in most MM cases and at least two-thirds of lymphomas using G-CSF alone. Age and body weight did not affect mobilization success. Clinicians should increase successful mobilizations on the first day of the apheresis and prescribe AHSCT at appropriate times to avoid excessive cycles of chemotherapy.


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APA

Hasbal, N.B., & Arat, M. (2023). Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study. Experimed, 13(3), 290-297. https://doi.org/10.26650/experimed.1383105


AMA

Hasbal N B, Arat M. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study. Experimed. 2023;13(3):290-297. https://doi.org/10.26650/experimed.1383105


ABNT

Hasbal, N.B.; Arat, M. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study. Experimed, [Publisher Location], v. 13, n. 3, p. 290-297, 2023.


Chicago: Author-Date Style

Hasbal, Nuri Barış, and Mutlu Arat. 2023. “Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study.” Experimed 13, no. 3: 290-297. https://doi.org/10.26650/experimed.1383105


Chicago: Humanities Style

Hasbal, Nuri Barış, and Mutlu Arat. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study.” Experimed 13, no. 3 (Mar. 2024): 290-297. https://doi.org/10.26650/experimed.1383105


Harvard: Australian Style

Hasbal, NB & Arat, M 2023, 'Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study', Experimed, vol. 13, no. 3, pp. 290-297, viewed 5 Mar. 2024, https://doi.org/10.26650/experimed.1383105


Harvard: Author-Date Style

Hasbal, N.B. and Arat, M. (2023) ‘Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study’, Experimed, 13(3), pp. 290-297. https://doi.org/10.26650/experimed.1383105 (5 Mar. 2024).


MLA

Hasbal, Nuri Barış, and Mutlu Arat. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study.” Experimed, vol. 13, no. 3, 2023, pp. 290-297. [Database Container], https://doi.org/10.26650/experimed.1383105


Vancouver

Hasbal NB, Arat M. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study. Experimed [Internet]. 5 Mar. 2024 [cited 5 Mar. 2024];13(3):290-297. Available from: https://doi.org/10.26650/experimed.1383105 doi: 10.26650/experimed.1383105


ISNAD

Hasbal, NuriBarış - Arat, Mutlu. Stem Cell Mobilization Efficiency and Engraftment Kinetics in Patients with Hematologic Malignancies Undergoing Autologous Stem Cell Transplantation: A Retrospective Cohort Study”. Experimed 13/3 (Mar. 2024): 290-297. https://doi.org/10.26650/experimed.1383105



TIMELINE


Submitted30.10.2023
Accepted01.12.2023
Published Online28.12.2023

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