Research Article


DOI :10.26650/IstanbulJPharm.2022.998774   IUP :10.26650/IstanbulJPharm.2022.998774    Full Text (PDF)

Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens

Müjgan ÖzfenerciElif Burcu BaliDemet ErdönmezUfuk Koca Çalışkan

Background and Aims: Aromatherapy, as one of the complementary therapies, uses essential oils as the main therapeutic agents to treat several diseases. In the present study, it was aimed to investigate inhibition of quorum sensing (QS) and biofilm formation of aromatherapeutic essential oils (AEOs) and their pharmaceutical combinations (PC-I and PC-II). Methods: The anti-QS potential of AEOs were determined using the biosensor strains Chromobacterium violaceum ATCC 12472 and Pseudomonas aeruginosa PAO1. Anti-QS activity was detected by agar-well diffusion and violacein pigment inhibition assays. Blocking of PAO1 swim and swarm motilities and biofilm formation was also performed. Results: Most of the AEOs demonstrated highly active (>95%) violacein pigment inhibition. Additionally, they inhibited swarming (40.34%-72.80%) and swimming (20.06%-50.08%) motilities of PAO1. Moreover, the majority of AEOs also decreased the biofilm formation, particularly on P. aeruginosa and S. aureus. Conclusion: Consequently, aromatherapeutic formulations might be a complementary or prophylactic cure for infectious disease by their anti-QS and antibiofilm activities rather than just antimicrobial effects.


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APA

Özfenerci, M., Bali, E.B., Erdönmez, D., & Koca Çalışkan, U. (2022). Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens. İstanbul Journal of Pharmacy, 52(1), 54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774


AMA

Özfenerci M, Bali E B, Erdönmez D, Koca Çalışkan U. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens. İstanbul Journal of Pharmacy. 2022;52(1):54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774


ABNT

Özfenerci, M.; Bali, E.B.; Erdönmez, D.; Koca Çalışkan, U. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 1, p. 54-63, 2022.


Chicago: Author-Date Style

Özfenerci, Müjgan, and Elif Burcu Bali and Demet Erdönmez and Ufuk Koca Çalışkan. 2022. “Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens.” İstanbul Journal of Pharmacy 52, no. 1: 54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774


Chicago: Humanities Style

Özfenerci, Müjgan, and Elif Burcu Bali and Demet Erdönmez and Ufuk Koca Çalışkan. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens.” İstanbul Journal of Pharmacy 52, no. 1 (Aug. 2022): 54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774


Harvard: Australian Style

Özfenerci, M & Bali, EB & Erdönmez, D & Koca Çalışkan, U 2022, 'Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens', İstanbul Journal of Pharmacy, vol. 52, no. 1, pp. 54-63, viewed 8 Aug. 2022, https://doi.org/10.26650/IstanbulJPharm.2022.998774


Harvard: Author-Date Style

Özfenerci, M. and Bali, E.B. and Erdönmez, D. and Koca Çalışkan, U. (2022) ‘Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens’, İstanbul Journal of Pharmacy, 52(1), pp. 54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774 (8 Aug. 2022).


MLA

Özfenerci, Müjgan, and Elif Burcu Bali and Demet Erdönmez and Ufuk Koca Çalışkan. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens.” İstanbul Journal of Pharmacy, vol. 52, no. 1, 2022, pp. 54-63. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2022.998774


Vancouver

Özfenerci M, Bali EB, Erdönmez D, Koca Çalışkan U. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens. İstanbul Journal of Pharmacy [Internet]. 8 Aug. 2022 [cited 8 Aug. 2022];52(1):54-63. Available from: https://doi.org/10.26650/IstanbulJPharm.2022.998774 doi: 10.26650/IstanbulJPharm.2022.998774


ISNAD

Özfenerci, Müjgan - Bali, ElifBurcu - Erdönmez, Demet - Koca Çalışkan, Ufuk. Aromatherapeutic essential oils and their pharmaceutical combinations: Tools for inhibition of quorum sensing activity and biofilm formation of human pathogens”. İstanbul Journal of Pharmacy 52/1 (Aug. 2022): 54-63. https://doi.org/10.26650/IstanbulJPharm.2022.998774



TIMELINE


Submitted22.09.2021
Accepted15.12.2021
Published Online28.04.2022

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