Research Article


DOI :10.26650/IstanbulJPharm.2020.0064   IUP :10.26650/IstanbulJPharm.2020.0064    Full Text (PDF)

Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey

Mehmet AkyüzIşık Didem KaragözŞule İnciİbrahim Halil KılıçSevda KırbağBaşak Simitçioğlu

Background and Aims: This study aims to investigate the cytotoxicity and DNA protective effects of semi-arid, arid, or desert truffles such as the Terfezia and Picoa species. Methods: The DNA protective effects of the Terfezia and Picoa species was evaluated using plasmid pBR322 DNA treated with UV and H2O2. The cytotoxic effects of water and methanol extracts of the Terfezia and Picoa species on H1299 and HUVEC cells were evaluated using the MTT assay. Results: Higher concentrations of T. olbiensis and P. lefebvrei extracts have demonstrated a DNA protective effect. The water extract of P. juniperi only at a 40 mg/mL concentration demonstrated a DNA-protective effect, whereas T. boudieri extract did not show any DNA-protective effect at all concentrations tested. H1299 cells showed more sensitivity to the water extract of T. olbiensis (4.66%), P. juniperi (12.04%), P. lefebvrei (21.93%), and the methanol extract of T. boudieri (20.93%). In general, the water and methanol extracts of the Terfezia and Picoa species demonstrated the least cytotoxic effects on HUVEC cells, except for the water extract of P. juniperi (38.46%). Conclusions: In conclusion, results obtained from this study show that the Terfezia and Picoa truffle species have potential DNA protective and cancer prevention properties.


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APA

Akyüz, M., Karagöz, I.D., İnci, Ş., Kılıç, İ.H., Kırbağ, S., & Simitçioğlu, B. (2021). Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy, 51(2), 198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064


AMA

Akyüz M, Karagöz I D, İnci Ş, Kılıç İ H, Kırbağ S, Simitçioğlu B. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy. 2021;51(2):198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064


ABNT

Akyüz, M.; Karagöz, I.D.; İnci, Ş.; Kılıç, İ.H.; Kırbağ, S.; Simitçioğlu, B. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy, [Publisher Location], v. 51, n. 2, p. 198-203, 2021.


Chicago: Author-Date Style

Akyüz, Mehmet, and Işık Didem Karagöz and Şule İnci and İbrahim Halil Kılıç and Sevda Kırbağ and Başak Simitçioğlu. 2021. “Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey.” İstanbul Journal of Pharmacy 51, no. 2: 198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064


Chicago: Humanities Style

Akyüz, Mehmet, and Işık Didem Karagöz and Şule İnci and İbrahim Halil Kılıç and Sevda Kırbağ and Başak Simitçioğlu. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey.” İstanbul Journal of Pharmacy 51, no. 2 (Sep. 2021): 198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064


Harvard: Australian Style

Akyüz, M & Karagöz, ID & İnci, Ş & Kılıç, İH & Kırbağ, S & Simitçioğlu, B 2021, 'Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey', İstanbul Journal of Pharmacy, vol. 51, no. 2, pp. 198-203, viewed 24 Sep. 2021, https://doi.org/10.26650/IstanbulJPharm.2020.0064


Harvard: Author-Date Style

Akyüz, M. and Karagöz, I.D. and İnci, Ş. and Kılıç, İ.H. and Kırbağ, S. and Simitçioğlu, B. (2021) ‘Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey’, İstanbul Journal of Pharmacy, 51(2), pp. 198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064 (24 Sep. 2021).


MLA

Akyüz, Mehmet, and Işık Didem Karagöz and Şule İnci and İbrahim Halil Kılıç and Sevda Kırbağ and Başak Simitçioğlu. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey.” İstanbul Journal of Pharmacy, vol. 51, no. 2, 2021, pp. 198-203. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2020.0064


Vancouver

Akyüz M, Karagöz ID, İnci Ş, Kılıç İH, Kırbağ S, Simitçioğlu B. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey. İstanbul Journal of Pharmacy [Internet]. 24 Sep. 2021 [cited 24 Sep. 2021];51(2):198-203. Available from: https://doi.org/10.26650/IstanbulJPharm.2020.0064 doi: 10.26650/IstanbulJPharm.2020.0064


ISNAD

Akyüz, Mehmet - Karagöz, IşıkDidem - İnci, Şule - Kılıç, İbrahimHalil - Kırbağ, Sevda - Simitçioğlu, Başak. Cytotoxicity and DNA protective effects of the Terfezia and Picoa species from the eastern region of Turkey”. İstanbul Journal of Pharmacy 51/2 (Sep. 2021): 198-203. https://doi.org/10.26650/IstanbulJPharm.2020.0064



TIMELINE


Submitted16.09.2020
Accepted16.09.2020
Published Online31.08.2021

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