İstanbul Journal of Pharmacy

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Research Article


DOI :10.26650/IstanbulJPharm.2023.1061291   IUP :10.26650/IstanbulJPharm.2023.1061291    Full Text (PDF)

Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery

Vidya Sabale, Vandana Rohit, Shweta Kale, Prafulla Sabale

Background and Aims: The aim of the present research work was to develop and optimize statistically carvedilol floating beads for chronotherapeutic drug delivery.

Methods: Multiple unit floating pulsatile beads of carvedilol were prepared by simple ionotropic gelation method intended for chronotherapy of hypertension. Pectin and sodium alginates were used as matrix forming, polymer and sodium bicarbonate was used as floating agent. A 23 full factorial design was applied to investigate the combined effect of three independent formulation variables namely amount of sodium alginate, sodium bicarbonate and calcium chloride on the dependent variables as % entrapment efficiency, floating lag time and drug release percentage.

Results: The formulation was optimized and tested based on its drug release pattern which presented minimum drug release in 0.1 N HCl and after 6 h lag time period and showed maximum drug release in 6.8 pH phosphate buffer by burst release within 45 mins. Surface response plots were presented graphically to represent the effect of independent variables on floating lag time, entrapment efficiency and drug release in 0.1 N HCl. The generated mathematical model for each response was validated and checked by formulating three extra-design checkpoint batches. There were no significant changes in drug content, floating lag time, entrapment efficiency and drug release of the formulation following its stability studies at 40 0 C and 75% relative humidity.

Conclusion: It was concluded that the floating beads were successfully formulated for chronotherapy of hypertension giving site- and time specific release of drug.

Keywords: Floating beads, drug release, chronotherapy, ionotropic gelation, hypertension

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APA

Sabale, V., Rohit, V., Kale, S., & Sabale, P. (2023). Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery. İstanbul Journal of Pharmacy, 53(2), 140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291


AMA

Sabale V, Rohit V, Kale S, Sabale P. Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery. İstanbul Journal of Pharmacy. 2023;53(2):140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291


ABNT

Sabale, V.; Rohit, V.; Kale, S.; Sabale, P. Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 2, p. 140-149, 2023.


Chicago: Author-Date Style

Sabale, Vidya, and Vandana Rohit and Shweta Kale and Prafulla Sabale. 2023. “Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery.” İstanbul Journal of Pharmacy 53, no. 2: 140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291


Chicago: Humanities Style

Sabale, Vidya, and Vandana Rohit and Shweta Kale and Prafulla Sabale. “Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery.” İstanbul Journal of Pharmacy 53, no. 2 (Sep. 2023): 140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291


Harvard: Australian Style

Sabale, V & Rohit, V & Kale, S & Sabale, P 2023, 'Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery', İstanbul Journal of Pharmacy, vol. 53, no. 2, pp. 140-149, viewed 30 Sep. 2023, https://doi.org/10.26650/IstanbulJPharm.2023.1061291


Harvard: Author-Date Style

Sabale, V. and Rohit, V. and Kale, S. and Sabale, P. (2023) ‘Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery’, İstanbul Journal of Pharmacy, 53(2), pp. 140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291 (30 Sep. 2023).


MLA

Sabale, Vidya, and Vandana Rohit and Shweta Kale and Prafulla Sabale. “Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery.” İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 140-149. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2023.1061291


Vancouver

Sabale V, Rohit V, Kale S, Sabale P. Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery. İstanbul Journal of Pharmacy [Internet]. 30 Sep. 2023 [cited 30 Sep. 2023];53(2):140-149. Available from: https://doi.org/10.26650/IstanbulJPharm.2023.1061291 doi: 10.26650/IstanbulJPharm.2023.1061291


ISNAD

Sabale, Vidya - Rohit, Vandana - Kale, Shweta - Sabale, Prafulla. “Development and statistical optimization of carvedilol floating beads for chronotherapeutic drug delivery”. İstanbul Journal of Pharmacy 53/2 (Sep. 2023): 140-149. https://doi.org/10.26650/IstanbulJPharm.2023.1061291



TIMELINE


Submitted22.01.2022
Accepted05.03.2023
Published Online28.08.2023

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