Research Article

DOI :10.26650/IstanbulJPharm.2022.964803   IUP :10.26650/IstanbulJPharm.2022.964803    Full Text (PDF)

In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes

Gözde Hasbal ÇelikokTuğba Yılmaz ÖzdenÖzlem SaçanAyşe CanRefiye Yanardağ

Background and Aims: The search for new enzyme inhibitors in plants is attractive because they can be used as drugs in the treatment of various diseases. Amaranthus spp. (Amaranthaceae) includes about 70 different species, some of which are edible and some of which are used in traditional medicine to treat various ailments. Amaranthus lividus L. is a vegetable whose stems and leaves are used for human consumption in Turkey. Methods: In this study, the in vitro enzyme inhibition potential of A. lividus on α-amylase, α-glucosidase, acetylcholinesterase (AChE), elastase, lipase, neuraminidase and tyrosinase was investigated for the first time. For this purpose, water extract of A. lividus was prepared. The tests of enzyme inhibitory activity were carried out by spectrophotometric and fluorometric methods. Results: The water extract showed significant α-glucosidase and α-amylase inhibitory activities. Also, it displayed good elastase, lipase and tyrosinase inhibitory activities. However, it exhibited low inhibitory activity on AChE and neuraminidase. Conclusion: The plant and its active constituents may be used as an antidiabetic enzyme inhibitor with future phytochemical constituent analysis.

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Hasbal Çelikok, G., Yılmaz Özden, T., Saçan, Ö., Can, A., & Yanardağ, R. (2022). In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes. İstanbul Journal of Pharmacy, 52(1), 73-79.


Hasbal Çelikok G, Yılmaz Özden T, Saçan Ö, Can A, Yanardağ R. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes. İstanbul Journal of Pharmacy. 2022;52(1):73-79.


Hasbal Çelikok, G.; Yılmaz Özden, T.; Saçan, Ö.; Can, A.; Yanardağ, R. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes. İstanbul Journal of Pharmacy, [Publisher Location], v. 52, n. 1, p. 73-79, 2022.

Chicago: Author-Date Style

Hasbal Çelikok, Gözde, and Tuğba Yılmaz Özden and Özlem Saçan and Ayşe Can and Refiye Yanardağ. 2022. “In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes.” İstanbul Journal of Pharmacy 52, no. 1: 73-79.

Chicago: Humanities Style

Hasbal Çelikok, Gözde, and Tuğba Yılmaz Özden and Özlem Saçan and Ayşe Can and Refiye Yanardağ. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes.” İstanbul Journal of Pharmacy 52, no. 1 (Aug. 2022): 73-79.

Harvard: Australian Style

Hasbal Çelikok, G & Yılmaz Özden, T & Saçan, Ö & Can, A & Yanardağ, R 2022, 'In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes', İstanbul Journal of Pharmacy, vol. 52, no. 1, pp. 73-79, viewed 8 Aug. 2022,

Harvard: Author-Date Style

Hasbal Çelikok, G. and Yılmaz Özden, T. and Saçan, Ö. and Can, A. and Yanardağ, R. (2022) ‘In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes’, İstanbul Journal of Pharmacy, 52(1), pp. 73-79. (8 Aug. 2022).


Hasbal Çelikok, Gözde, and Tuğba Yılmaz Özden and Özlem Saçan and Ayşe Can and Refiye Yanardağ. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes.” İstanbul Journal of Pharmacy, vol. 52, no. 1, 2022, pp. 73-79. [Database Container],


Hasbal Çelikok G, Yılmaz Özden T, Saçan Ö, Can A, Yanardağ R. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes. İstanbul Journal of Pharmacy [Internet]. 8 Aug. 2022 [cited 8 Aug. 2022];52(1):73-79. Available from: doi: 10.26650/IstanbulJPharm.2022.964803


Hasbal Çelikok, Gözde - Yılmaz Özden, Tuğba - Saçan, Özlem - Can, Ayşe - Yanardağ, Refiye. In vitro inhibitory potential of Amaranthus lividus L. against therapeutic target enzymes”. İstanbul Journal of Pharmacy 52/1 (Aug. 2022): 73-79.


Published Online19.01.2022


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