Research Article


DOI :10.26650/IstanbulJPharm.2023.1201106   IUP :10.26650/IstanbulJPharm.2023.1201106    Full Text (PDF)

Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization

Elif Nur TunçAfife Büşra Uğur KaplanYaşar Furkan KilinbozMeltem Çetin

Background and Aims: Epilepsy is one of the most disabling and most common neurological disorders, affecting approximately 65 million people of all age groups worldwide. When there is no response to monotherapy in the treatment of epilepsy, the combined use of Carbamazepine (CARBA) and Levetiracetam (LEV), which have different mechanisms of action, can be additive/synergistic and may be useful in the clinic. The aim of our study is to develop a fixed-dose combination (FDC)- nanoemulsion (NE) formulation containing CARBA and LEV for the treatment of epilepsy.

Methods: Blank NE (BLNK-NE) and CARBA+LEV-FDC-NE formulations were prepared and carried out the in vitro characterization studies [morphological analysis, centrifugation test, droplet size (DS), polydispersity index (PDI), zeta potential (ZP), viscosity and pH measurements, FT-IR analysis, the percent entrapment efficiency (EE%), and in vitro release study].

Results: The DS, PDI, pH, and ZP values for the BLNK-NE formulation were found to be 117.63±3.82 nm, 0.240±0.014, 4.62±0.03, and (-)26.07±3.04 mV, respectively. For the CARBA+LEV-FDC-NE formulation, the DS, PDI, pH, and ZP values were determined as 137.56±3.11 nm, 0.225±0.013, 4.60±0.06, and (-)21.62±0.29 mV, respectively. The EE% values obtained for CARBA+LEV-FDC-NE were 97.33±0.56% (for CARBA) and 96.73±0.91% (for LEV).

Conclusion: The CARBA+LEV-FDC-NE formulation was successfully prepared. This formulation had suitable in vitro characterization results.


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APA

Tunç, E.N., Uğur Kaplan, A.B., Kilinboz, Y.F., & Çetin, M. (2023). Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization. İstanbul Journal of Pharmacy, 53(2), 133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106


AMA

Tunç E N, Uğur Kaplan A B, Kilinboz Y F, Çetin M. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization. İstanbul Journal of Pharmacy. 2023;53(2):133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106


ABNT

Tunç, E.N.; Uğur Kaplan, A.B.; Kilinboz, Y.F.; Çetin, M. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization. İstanbul Journal of Pharmacy, [Publisher Location], v. 53, n. 2, p. 133-139, 2023.


Chicago: Author-Date Style

Tunç, Elif Nur, and Afife Büşra Uğur Kaplan and Yaşar Furkan Kilinboz and Meltem Çetin. 2023. “Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization.” İstanbul Journal of Pharmacy 53, no. 2: 133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106


Chicago: Humanities Style

Tunç, Elif Nur, and Afife Büşra Uğur Kaplan and Yaşar Furkan Kilinboz and Meltem Çetin. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization.” İstanbul Journal of Pharmacy 53, no. 2 (Feb. 2024): 133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106


Harvard: Australian Style

Tunç, EN & Uğur Kaplan, AB & Kilinboz, YF & Çetin, M 2023, 'Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization', İstanbul Journal of Pharmacy, vol. 53, no. 2, pp. 133-139, viewed 21 Feb. 2024, https://doi.org/10.26650/IstanbulJPharm.2023.1201106


Harvard: Author-Date Style

Tunç, E.N. and Uğur Kaplan, A.B. and Kilinboz, Y.F. and Çetin, M. (2023) ‘Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization’, İstanbul Journal of Pharmacy, 53(2), pp. 133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106 (21 Feb. 2024).


MLA

Tunç, Elif Nur, and Afife Büşra Uğur Kaplan and Yaşar Furkan Kilinboz and Meltem Çetin. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization.” İstanbul Journal of Pharmacy, vol. 53, no. 2, 2023, pp. 133-139. [Database Container], https://doi.org/10.26650/IstanbulJPharm.2023.1201106


Vancouver

Tunç EN, Uğur Kaplan AB, Kilinboz YF, Çetin M. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization. İstanbul Journal of Pharmacy [Internet]. 21 Feb. 2024 [cited 21 Feb. 2024];53(2):133-139. Available from: https://doi.org/10.26650/IstanbulJPharm.2023.1201106 doi: 10.26650/IstanbulJPharm.2023.1201106


ISNAD

Tunç, ElifNur - Uğur Kaplan, AfifeBüşra - Kilinboz, YaşarFurkan - Çetin, Meltem. Nanoemulsion formulation containing carbamazepine and levetiracetam: Development and in vitro characterization”. İstanbul Journal of Pharmacy 53/2 (Feb. 2024): 133-139. https://doi.org/10.26650/IstanbulJPharm.2023.1201106



TIMELINE


Submitted08.11.2022
Accepted17.05.2023
Published Online28.08.2023

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