Review


DOI :10.26650/JARHS2021-807525   IUP :10.26650/JARHS2021-807525    Full Text (PDF)

A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms

Nur Sena BaşarırBurcu MesutYıldız Özsoy Erginer

Current pharmaceutical approaches continue to favour oral dosage delivery systems above all other routes. This is due to ease of administration and increase in patient complaisance. A common objective of a drug delivery systems is to achieve a drug that could be taken in a single dosage form. Yet, drug delivery mechanisms generally lack certain characteristics such as an adequate oral bioavailability and a prolonged half-life. Floating drug delivery systems (FDDS) are systems that are a part of gastroretentive drug delivery systems (GRDDS) with low density that has floating ability over the gastric contents of the stomach. Floating dosage forms are taken orally and developed to increase the transit time of the active substance through the gastrointestinal tract and to achieve a systemic effect. The taken drug will remain at floating state in the stomach for an extended period without affecting the gastric emptying rate. FDDS provides an efficient method for improving the drug’s bioavailability, reducing drug waste and providing controlled drug delivery systems. This review will generally focus on FDDS as a GRDDS and classify alternative systems, such as non-floating systems, and briefly mention excipients used in order to obtain an effective gastroretentive system.

DOI :10.26650/JARHS2021-807525   IUP :10.26650/JARHS2021-807525    Full Text (PDF)

Güncel Bakış Açısı ile Yüzen Dozaj Formlarına Öncelik Vererek Gastroretentif İlaç Salım Sistemlerinin Derlemesi

Nur Sena BaşarırBurcu MesutYıldız Özsoy Erginer

Mevcut farmasötik yaklaşımlarda, diğer tüm yollarından farklı olarak halen oral dozaj formları tercih edilmeye devam etmektedir. Bunun nedeni uygulama kolaylığı ve hasta uyuncunun yüksek olmasıdır. İlaç salım sistemlerinin ortak amacı, ilacın tek bir dozaj formu olarak alınabilmesini sağlamaktır. Yine de, ilaç salım mekanizmaları genellikle uygun bir biyoyararlanım ve uzatılmış yarı ömür gibi özelliklerden yoksundur. Yüzebilen ilaç salım sistemleri (FDDS), mide içeriği üzerinde kalabilme özelliğine sahip, düşük yoğunluklu olan sistemlerdir ve gastroretentif ilaç salım sistemlerinin (GRDDS) bir parçası olarak değerlendirilirler. Yüzebilen dozaj formları ağızdan alınır ve etken maddenin gastrointestinal sistemden geçiş süresini uzatarak lokal/ sistemik etki elde etmek için geliştirilirler. Söz konusu ilaç mide boşalma hızını etkilemeden uzun süre midede yüzer halde kalır. FDDS ilaç biyoyararlanımını iyileştirir, ilaç israfını azaltır ve kontrollü ilaç salım sistemi etkisini sağlamak için etkili bir yöntem olarak değerlendirilir. Bu derleme, genellikle bir gastoretentif ilaç sistemlerinden birisi olan yüzebilen dozaj formlarına odaklanmıştır ve özetle gastrik sistemde kalabilen alternatif sistemlerden ve bu sistemleri geliştirmek için kullanılan eksipiyanlardan bahsedecektir.


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APA

Başarır, N.S., Mesut, B., & Özsoy Erginer, Y. (2021). A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms. Journal of Advanced Research in Health Sciences, 4(2), 43-64. https://doi.org/10.26650/JARHS2021-807525


AMA

Başarır N S, Mesut B, Özsoy Erginer Y. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms. Journal of Advanced Research in Health Sciences. 2021;4(2):43-64. https://doi.org/10.26650/JARHS2021-807525


ABNT

Başarır, N.S.; Mesut, B.; Özsoy Erginer, Y. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 4, n. 2, p. 43-64, 2021.


Chicago: Author-Date Style

Başarır, Nur Sena, and Burcu Mesut and Yıldız Özsoy Erginer. 2021. “A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms.” Journal of Advanced Research in Health Sciences 4, no. 2: 43-64. https://doi.org/10.26650/JARHS2021-807525


Chicago: Humanities Style

Başarır, Nur Sena, and Burcu Mesut and Yıldız Özsoy Erginer. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms.” Journal of Advanced Research in Health Sciences 4, no. 2 (Jun. 2022): 43-64. https://doi.org/10.26650/JARHS2021-807525


Harvard: Australian Style

Başarır, NS & Mesut, B & Özsoy Erginer, Y 2021, 'A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms', Journal of Advanced Research in Health Sciences, vol. 4, no. 2, pp. 43-64, viewed 30 Jun. 2022, https://doi.org/10.26650/JARHS2021-807525


Harvard: Author-Date Style

Başarır, N.S. and Mesut, B. and Özsoy Erginer, Y. (2021) ‘A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms’, Journal of Advanced Research in Health Sciences, 4(2), pp. 43-64. https://doi.org/10.26650/JARHS2021-807525 (30 Jun. 2022).


MLA

Başarır, Nur Sena, and Burcu Mesut and Yıldız Özsoy Erginer. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms.” Journal of Advanced Research in Health Sciences, vol. 4, no. 2, 2021, pp. 43-64. [Database Container], https://doi.org/10.26650/JARHS2021-807525


Vancouver

Başarır NS, Mesut B, Özsoy Erginer Y. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms. Journal of Advanced Research in Health Sciences [Internet]. 30 Jun. 2022 [cited 30 Jun. 2022];4(2):43-64. Available from: https://doi.org/10.26650/JARHS2021-807525 doi: 10.26650/JARHS2021-807525


ISNAD

Başarır, NurSena - Mesut, Burcu - Özsoy Erginer, Yıldız. A Review On Current Perspective Of Gastroretentive Drug Delivery Systems Prioritising Floating Dosage Forms”. Journal of Advanced Research in Health Sciences 4/2 (Jun. 2022): 43-64. https://doi.org/10.26650/JARHS2021-807525



TIMELINE


Submitted08.10.2020
Accepted20.01.2021
Published Online19.06.2021

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