Meeting Abstract


DOI :10.26650/JARHS2021-1137378   IUP :10.26650/JARHS2021-1137378    Full Text (PDF)

ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY

Burçin BaranGamze SanlavDeniz KızmazoğluSelen Kum ÖzşengezerSafiye AktaşZekiye AltunNur Olgun

Objective: Tribbles protein (TRIB) family was first identified in Drosophila, plays role in coordinating cell division and morphogenesis. TRIB3 is one of the members of this family, its protein expression levels and patient prognosis has been examined in various studies. While TRIB3 expression was correlated with poor prognosis in hepatocellular cancer patients, its expression levels were associated with increased disease-free survival and a better response to therapy in luminal breast cancer patients. Neuroblastoma (NB) is the most common solid tumor in children and accounts for ~15% of childhood cancer‐related mortality. In the present study, we aimed the investigate the TRIB3 expression levels among NB patients and to determine if TRIB3 expression levels could be prognostic biomarker for NB. Materials and Methods: 40 children with different stages of NB were studied. The patients were staged according to criteria defined by Turkish Pediatric Oncology Group and International Neuroblastoma Staging System. Protein expression levels of TRIB3 was determined with immunohistochemical staining on paraffin sections of NB patient tissue samples. All sections were independently and blindly studied for protein expression under microscopic examination. P values <0.05 was accepted statistically significant. Results: TRIB3 expression was found to be upregulated in low grade samples and ganglioneuroblastoma samples and downregulated in neuroblastoma cells in the tissue sections of high-grade NB samples. Conclusion: While study is still ongoing, preliminary results showed that TRIB3 could be a candidate prognostic marker for NB patients. 


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    APA

    Baran, B., Sanlav, G., Kızmazoğlu, D., Kum Özşengezer, S., Aktaş, S., Altun, Z., & Olgun, N. (2022). ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY. Journal of Advanced Research in Health Sciences, 5(1), 56-56. https://doi.org/10.26650/JARHS2021-1137378


    AMA

    Baran B, Sanlav G, Kızmazoğlu D, Kum Özşengezer S, Aktaş S, Altun Z, Olgun N. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY. Journal of Advanced Research in Health Sciences. 2022;5(1):56-56. https://doi.org/10.26650/JARHS2021-1137378


    ABNT

    Baran, B.; Sanlav, G.; Kızmazoğlu, D.; Kum Özşengezer, S.; Aktaş, S.; Altun, Z.; Olgun, N. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 56-56, 2022.


    Chicago: Author-Date Style

    Baran, Burçin, and Gamze Sanlav and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. 2022. “ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY.” Journal of Advanced Research in Health Sciences 5, no. 1: 56-56. https://doi.org/10.26650/JARHS2021-1137378


    Chicago: Humanities Style

    Baran, Burçin, and Gamze Sanlav and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 56-56. https://doi.org/10.26650/JARHS2021-1137378


    Harvard: Australian Style

    Baran, B & Sanlav, G & Kızmazoğlu, D & Kum Özşengezer, S & Aktaş, S & Altun, Z & Olgun, N 2022, 'ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 56-56, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1137378


    Harvard: Author-Date Style

    Baran, B. and Sanlav, G. and Kızmazoğlu, D. and Kum Özşengezer, S. and Aktaş, S. and Altun, Z. and Olgun, N. (2022) ‘ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY’, Journal of Advanced Research in Health Sciences, 5(1), pp. 56-56. https://doi.org/10.26650/JARHS2021-1137378 (24 Feb. 2024).


    MLA

    Baran, Burçin, and Gamze Sanlav and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 56-56. [Database Container], https://doi.org/10.26650/JARHS2021-1137378


    Vancouver

    Baran B, Sanlav G, Kızmazoğlu D, Kum Özşengezer S, Aktaş S, Altun Z, Olgun N. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):56-56. Available from: https://doi.org/10.26650/JARHS2021-1137378 doi: 10.26650/JARHS2021-1137378


    ISNAD

    Baran, Burçin - Sanlav, Gamze - Kızmazoğlu, Deniz - Kum Özşengezer, Selen - Aktaş, Safiye - Altun, Zekiye - Olgun, Nur. ANALYSIS OF TRIBBLES HOMOLOG 3 (TRIB3) EXPRESSION LEVELS IN NEUROBLASTOMA: PRELIMINARY STUDY”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 56-56. https://doi.org/10.26650/JARHS2021-1137378



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    Published Online09.08.2022

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