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Case Report


DOI :10.26650/JARHS2021-826059   IUP :10.26650/JARHS2021-826059    Full Text (PDF)

Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia

Aylin Canbolat Ayhan, Ahmet Baysal, Öykü Tosun

In acute promyelocytic leukemia (APL) potentially fatal coagulopathy and hemorrhages remain major causes of induction failure. Serious thrombotic events are frequently reported at the diagnosis or following remission induction therapy with all-trans-retinoic acid (ATRA), which is a key point in treatment of APL. On the other hand, isolated right ventricular (RV) thrombus is a life-threatening condition and in cancer patients it has been rarely reported. In this report, we have described a very rare a case of ATRA-related isolated right-sided intracardiac thrombus in a nine-year-old child with APL that developed after achievement of complete remission, during the 4th course of ATRA, which is an unexpected period for ATRArelated thrombotic events. We aimed to emphasize the importance of side effects of ATRA and increase awareness against such life-threatening complications. Thrombosis mustn’t be expected only during differentiation syndrome; it should be kept in mind in every phase of treatment with ATRA.

Keywords: Acute promyelocytic leukemia, All-trans-retinoic acid, Intracardiac thrombus
DOI :10.26650/JARHS2021-826059   IUP :10.26650/JARHS2021-826059    Full Text (PDF)

Akut Promyelositik Lösemili Çocuk Hastada All-Trans-Retinoik Asit Tedavisiyle İlişkili İntrakardiyak Tromboz

Aylin Canbolat Ayhan, Ahmet Baysal, Öykü Tosun

Ölümcül koagulopatiler ve hemorajiler akut promiyelositik lösemide (APL) indüksiyon tedavisine yanıt alınamamasının temel sebeplerini oluşturmaktadır. Ağır trombotik olaylar genellikle tanı sırasında ya da tedavinin kilit noktasını oluşturan all-trans-retinoik asit (ATRA) ile remisyon indüksiyon tedavisine başlanmasından hemen sonra gelişir. Diğer yandan izole sağ ventrikül içi tromboz hayatı tehdit edici bir patoloji olup kanser hastalarında nadir olarak saptanmıştır. Bu çalışmada remisyonda iken sağ ventriküler kardiyak trombüs gelişen dokuz yaşındaki APL olgusu nadir görülmesi nedeniyle sunulmuştur. ATRA’nın yan etkilerinin öneminin gösterilmesi, ölümcül olabilen komplikasyonların vurgulanması amaçlanmıştır. Trombozun sadece diferansiyasyon sendromunu sırasında değil tedavinin her döneminde gelişebileceği akılda tutulmalıdır

Keywords: Akut promiyelositik lösemi, All-Trans-Retinoik Asit, İntrakardiyak tromboz

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APA

Canbolat Ayhan, A., Baysal, A., & Tosun, Ö. (2021). Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia. Journal of Advanced Research in Health Sciences, 4(2), 81-86. https://doi.org/10.26650/JARHS2021-826059


AMA

Canbolat Ayhan A, Baysal A, Tosun Ö. Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia. Journal of Advanced Research in Health Sciences. 2021;4(2):81-86. https://doi.org/10.26650/JARHS2021-826059


ABNT

Canbolat Ayhan, A.; Baysal, A.; Tosun, Ö. Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 4, n. 2, p. 81-86, 2021.


Chicago: Author-Date Style

Canbolat Ayhan, Aylin, and Ahmet Baysal and Öykü Tosun. 2021. “Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia.” Journal of Advanced Research in Health Sciences 4, no. 2: 81-86. https://doi.org/10.26650/JARHS2021-826059


Chicago: Humanities Style

Canbolat Ayhan, Aylin, and Ahmet Baysal and Öykü Tosun. “Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia.” Journal of Advanced Research in Health Sciences 4, no. 2 (Dec. 2024): 81-86. https://doi.org/10.26650/JARHS2021-826059


Harvard: Australian Style

Canbolat Ayhan, A & Baysal, A & Tosun, Ö 2021, 'Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia', Journal of Advanced Research in Health Sciences, vol. 4, no. 2, pp. 81-86, viewed 14 Dec. 2024, https://doi.org/10.26650/JARHS2021-826059


Harvard: Author-Date Style

Canbolat Ayhan, A. and Baysal, A. and Tosun, Ö. (2021) ‘Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia’, Journal of Advanced Research in Health Sciences, 4(2), pp. 81-86. https://doi.org/10.26650/JARHS2021-826059 (14 Dec. 2024).


MLA

Canbolat Ayhan, Aylin, and Ahmet Baysal and Öykü Tosun. “Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia.” Journal of Advanced Research in Health Sciences, vol. 4, no. 2, 2021, pp. 81-86. [Database Container], https://doi.org/10.26650/JARHS2021-826059


Vancouver

Canbolat Ayhan A, Baysal A, Tosun Ö. Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia. Journal of Advanced Research in Health Sciences [Internet]. 14 Dec. 2024 [cited 14 Dec. 2024];4(2):81-86. Available from: https://doi.org/10.26650/JARHS2021-826059 doi: 10.26650/JARHS2021-826059


ISNAD

Canbolat Ayhan, Aylin - Baysal, Ahmet - Tosun, Öykü. “Intracardiac Thrombus Associated with All-Trans-Retinoic Acid Treatment in a Child with Acute Promyelocytic Leukemia”. Journal of Advanced Research in Health Sciences 4/2 (Dec. 2024): 81-86. https://doi.org/10.26650/JARHS2021-826059



TIMELINE


Submitted15.11.2020
Accepted06.05.2021
Published Online19.06.2021

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