Meeting Abstract


DOI :10.26650/JARHS2021-1137390   IUP :10.26650/JARHS2021-1137390    Full Text (PDF)

NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES

Burcu Bakır Güngör

The tremendous boost in the next generation sequencing technologies and in the “omics” technologies makes it possible to look for the coordinated behavior among different levels of biochemical activity. Irrespective of the technology used, the advent of high-throughput profiling technologies presents a new challenge, that of interpretation of these data in a meaningful manner – to uncover relationships that are not readily apparent between molecular profiles and states of health or disease. In contrast to isolated molecules, network and pathway oriented analyses are thought to better capture pathological perturbations and hence, better explain predisposition to disease. In this talk, firstly I will introduce different types of multi-omics data integration methods. Along this line, I will present existing trans-omics, merge-omics, multi-omics, panomics strategies as an example of integrative omics studies. Secondly, I will focus on network and pathway based integration techniques. In this respect, I will mention different functional enrichment analysis techniques including over-representation analysis (ORA), gene set enrichment analysis (GSEA) methods, integrative and modular enrichment analysis (MEA). Thirdly, I will summarize our approach and present how this approach can help us to identify disease-associated pathway markers. Lastly, I will conclude via discussing how these pathway markers can help us to enlighten individual disease development mechanisms and personalized targets for treatments, and hence bridging the gap between the -omics data and precision medicine. 


PDF View

References

    Citations

    Copy and paste a formatted citation or use one of the options to export in your chosen format


    EXPORT



    APA

    Bakır Güngör, B. (2022). NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES. Journal of Advanced Research in Health Sciences, 5(1), 65-68. https://doi.org/10.26650/JARHS2021-1137390


    AMA

    Bakır Güngör B. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES. Journal of Advanced Research in Health Sciences. 2022;5(1):65-68. https://doi.org/10.26650/JARHS2021-1137390


    ABNT

    Bakır Güngör, B. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 65-68, 2022.


    Chicago: Author-Date Style

    Bakır Güngör, Burcu,. 2022. “NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES.” Journal of Advanced Research in Health Sciences 5, no. 1: 65-68. https://doi.org/10.26650/JARHS2021-1137390


    Chicago: Humanities Style

    Bakır Güngör, Burcu,. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 65-68. https://doi.org/10.26650/JARHS2021-1137390


    Harvard: Australian Style

    Bakır Güngör, B 2022, 'NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 65-68, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1137390


    Harvard: Author-Date Style

    Bakır Güngör, B. (2022) ‘NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES’, Journal of Advanced Research in Health Sciences, 5(1), pp. 65-68. https://doi.org/10.26650/JARHS2021-1137390 (24 Feb. 2024).


    MLA

    Bakır Güngör, Burcu,. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 65-68. [Database Container], https://doi.org/10.26650/JARHS2021-1137390


    Vancouver

    Bakır Güngör B. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):65-68. Available from: https://doi.org/10.26650/JARHS2021-1137390 doi: 10.26650/JARHS2021-1137390


    ISNAD

    Bakır Güngör, Burcu. NETWORK AND PATHWAY BASED ANALYSIS OF MULTI-OMIC DATA TO ENLIGHTEN MOLECULAR MECHANISMS OF COMPLEX DISEASES”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 65-68. https://doi.org/10.26650/JARHS2021-1137390



    TIMELINE


    Published Online09.08.2022

    LICENCE


    Attribution-NonCommercial (CC BY-NC)

    This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


    SHARE




    Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.