Meeting Abstract


DOI :10.26650/JARHS2021-1136890   IUP :10.26650/JARHS2021-1136890    Full Text (PDF)

S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA

Gamze SanlavBurçin BaranDeniz KızmazoğluSelen Kum ÖzşengezerSafiye AktaşZekiye AltunNur Olgun

Objective: S-100 is an acidic-calcium-binding protein and was first described in cells of neuroendocrine origin. It plays an important role in various cellular processes such as cell differentiation and proliferation. S-100 is described to be a negative prognostic marker for the advanced stages of melanoma and was evaluated to be prognostic biomarker for different cancers. Neuroblastoma(NB) is remarkable for its broad spectrum of clinical behavior, varying from spontaneous regression to progressive disease and accounts for ~15% of childhood cancer‐related mortality. This diversity in behavior correlates closely with defined clinical and biologic features and combinations of prognostic variables are used for risk-group assignment. The aim of this study is to investigate the S-100 expression levels among neuroblastoma patients and to determine if S-100 expression levels could be prognostic biomarker for neuroblastoma. Materials and Methods: Histological tumor sections of 40 cases of varying stages and risk groups of neuroblastoma were studied. The patients were staged according to criteria defined by Turkish Pediatric Oncology Group and International Neuroblastoma Staging System(INSS). Risk groups were determined according to the International Neuroblastoma Risk Group(INRG) classification system. S-100 protein expression levels were evaluated by immunohistochemical staining on paraffin sections of neuroblastoma patient tissue samples. All sections were independently and blindly studied for protein expression under microscopic examination. P values<0.05 was accepted statistically significant. Results: Schwann cells in the ganglioneuromas and ganglioneuroblastomas always strongly stained. Neuroblastoma cases with early stage and low-to-intermediate risk showed upregulated expression. Conclusion: While study is still ongoing, preliminary results showed that S-100 could be a candidate prognostic marker for neuroblastoma patients.


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    APA

    Sanlav, G., Baran, B., Kızmazoğlu, D., Kum Özşengezer, S., Aktaş, S., Altun, Z., & Olgun, N. (2022). S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA. Journal of Advanced Research in Health Sciences, 5(1), 55-55. https://doi.org/10.26650/JARHS2021-1136890


    AMA

    Sanlav G, Baran B, Kızmazoğlu D, Kum Özşengezer S, Aktaş S, Altun Z, Olgun N. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA. Journal of Advanced Research in Health Sciences. 2022;5(1):55-55. https://doi.org/10.26650/JARHS2021-1136890


    ABNT

    Sanlav, G.; Baran, B.; Kızmazoğlu, D.; Kum Özşengezer, S.; Aktaş, S.; Altun, Z.; Olgun, N. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 5, n. 1, p. 55-55, 2022.


    Chicago: Author-Date Style

    Sanlav, Gamze, and Burçin Baran and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. 2022. “S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA.” Journal of Advanced Research in Health Sciences 5, no. 1: 55-55. https://doi.org/10.26650/JARHS2021-1136890


    Chicago: Humanities Style

    Sanlav, Gamze, and Burçin Baran and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA.” Journal of Advanced Research in Health Sciences 5, no. 1 (Feb. 2024): 55-55. https://doi.org/10.26650/JARHS2021-1136890


    Harvard: Australian Style

    Sanlav, G & Baran, B & Kızmazoğlu, D & Kum Özşengezer, S & Aktaş, S & Altun, Z & Olgun, N 2022, 'S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA', Journal of Advanced Research in Health Sciences, vol. 5, no. 1, pp. 55-55, viewed 24 Feb. 2024, https://doi.org/10.26650/JARHS2021-1136890


    Harvard: Author-Date Style

    Sanlav, G. and Baran, B. and Kızmazoğlu, D. and Kum Özşengezer, S. and Aktaş, S. and Altun, Z. and Olgun, N. (2022) ‘S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA’, Journal of Advanced Research in Health Sciences, 5(1), pp. 55-55. https://doi.org/10.26650/JARHS2021-1136890 (24 Feb. 2024).


    MLA

    Sanlav, Gamze, and Burçin Baran and Deniz Kızmazoğlu and Selen Kum Özşengezer and Safiye Aktaş and Zekiye Altun and Nur Olgun. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA.” Journal of Advanced Research in Health Sciences, vol. 5, no. 1, 2022, pp. 55-55. [Database Container], https://doi.org/10.26650/JARHS2021-1136890


    Vancouver

    Sanlav G, Baran B, Kızmazoğlu D, Kum Özşengezer S, Aktaş S, Altun Z, Olgun N. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA. Journal of Advanced Research in Health Sciences [Internet]. 24 Feb. 2024 [cited 24 Feb. 2024];5(1):55-55. Available from: https://doi.org/10.26650/JARHS2021-1136890 doi: 10.26650/JARHS2021-1136890


    ISNAD

    Sanlav, Gamze - Baran, Burçin - Kızmazoğlu, Deniz - Kum Özşengezer, Selen - Aktaş, Safiye - Altun, Zekiye - Olgun, Nur. S-100 PROTEIN EXPRESSION LEVELS AS A POTENTIAL PROGNOSTIC MARKER IN NEUROBLASTOMA”. Journal of Advanced Research in Health Sciences 5/1 (Feb. 2024): 55-55. https://doi.org/10.26650/JARHS2021-1136890



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    Published Online09.08.2022

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