BÖLÜM


DOI :10.26650/BB/CH22.2020.008.27   IUP :10.26650/BB/CH22.2020.008.27    Tam Metin (PDF)

COVID-19 (SARS-CoV-2) Tedavisinde Klinik Çalışmalarda Yer Alan Bitkisel Kökenli Doğal Bileşikler

Emine AkalınMiraç EkiciZinar AlanAyşenur Yaman BucakAli Yağız Üresin

COVID-19 küresel salgınında, hastalığın tedavisi ve profilaksisi için, dünyada çok sayıda ilaç ve doğal kaynaklı etken madde denenmektedir. Her ne kadar, her ülkede hastalığın ölümcül etkisini azaltmak için tedavi protokolleri geliştirilse de önleme ve tedavi için herhangi bir ilaç veya doğal bileşik bulunmamıştır. Derlemede seçilen etken maddeler, sentetik olmayan bitkilerden elde edilen etken maddelerdir. Doğal bileşiklerin en çok test edildiği ülke Çin iken, birçok Avrupa ülkesinde de çalışmalar yapılmaktadır. Çalışmaya, kolşisin, kurkumin, artemisinin, resveratrol, silimarin, timokinon, essin, hesperidin, diosmin ve kersetinden oluşan on adet doğal kaynaklı bileşik dâhil edilmiştir. Bu maddeler tek başlarına veya kombine halde kullanılmaktadır. Kolşisin en çok çalışılan maddedir. Seçilen doğal bileşiklerin COVID-19 üzerine etki mekanizmaları genel olarak antiviral etki ve enflamatuvar sitokinlerin sentezini baskılayarak ortaya çıkan antienflamatuvar aktivite ile tanımlanmaktadır. Antiviral etki mekanizmalarından biri olarak en sık araştırılan ACE2 reseptörleri aracılığıyla hücrelere viral girişi etkileyecek bitkisel kökenli etkin maddelerin araştırıldığı in vitro çalışmalar mevcuttur. COVID-19 enfeksiyonu tedavisinde, doğal bileşiklerin etkinliği ile ilgili sonuçların görülmesi ve değerlendirilmesi için tüm çalışmaların tamamlanmış olması gerekmektedir. Bitki kökenli bileşiklerin en başta gelen dezavantajı ise, haklarında sentetik bileşiklere göre çok daha az klinik çalışma yapılmış olmasıdır.


DOI :10.26650/BB/CH22.2020.008.27   IUP :10.26650/BB/CH22.2020.008.27    Tam Metin (PDF)

Plant-Based Natural Compounds in Clinical Trials of COVID-19 (SARS-Cov-2) Treatment

Emine AkalınMiraç EkiciZinar AlanAyşenur Yaman BucakAli Yağız Üresin

Numerous drug and active natural substances for the treatment and prophylaxis during the COVID-19 pandemic are being tested all over the world. However, although treatment protocols are being developed in each country, in order to reduce the lethal effects of the disease, no drugs or natural compounds have been defined for the prevention and treatment of COVID-19. In this review, the selected active compounds are plant-derived substances and are not synthesised. While the country where natural compounds are being tested most frequently is China, they are also being tried in many countries, especially European countries. Ten natural compounds have been included in the study; colchicine, curcumin, artemisinin, resveratrol, silymarin, thymoquinone, aescin, hesperidin, diosmin and quercetin. These products are being used either alone or in combination. Colchicine is being tested most frequently. The general mechanisms of action of the selected natural compounds on COVID-19 are being identified with antiviral effects and anti-inflammatory activity by inhibiting the synthesis of inflammatory cytokines. There are in vitro studies investigating some plant-based active substances that can interfere with viral entry into cells via ACE2 receptors. This is one of the most frequently investigated antiviral mechanisms of action. In the treatment of COVID-19 infection, all clinical trials must be completed in order to understand and evaluate the results of the effectiveness of natural compounds. The main disadvantage in plant-based compounds is that less clinical trials are conducted compared to synthetic compounds.



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