Sağlık Bilimlerinde İleri Araştırmalar Dergisi

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DOI :10.26650/JARHS2021-700825   IUP :10.26650/JARHS2021-700825    Tam Metin (PDF)

Çocuklarda Miyelodisplastik Sendrom

Gül Nihal Özdemir

Miyelodisplastik sendrom (MDS); sitopeni, displazi ve inefektif eritropoyez ile karakterize klonal bir kök hücre bozukluğudur. Çocuklarda MDS erişkinlere göre oldukça nadir görülür. Miyelodisplastik sendromda en sık sitopeni ile ilişkili şikayetler görülür. Kanama, enfeksiyon ve solukluk sık bulgulardır. Tanı klinik bulgular, morfoloji, immünfenotip ve sitogenetik tetkiklerle konulur. Açıklanamayan uzun süren sitopeni, en az bir seride displazi, klonal sitogenetik anomali ve artmış blast sayısı tanı kriterleridir ve en az ikisinin olması tanıda yol göstericidir. Çocukluk çağı ve erişkin MDS arasında hem sınıflama, hem altta yatan hastalıklar hem de tedavi yaklaşımları açısından önemli farklılıklar vardır. Bu yazıda erişkin dönemde ortaya çıkan MDS ile karşılaştırılarak çocukluk çağında MDS anlatılmıştır.

Anahtar Kelimeler: Miyelodisplastik sendrom, Çocuk, Displazi, Sitopeni
DOI :10.26650/JARHS2021-700825   IUP :10.26650/JARHS2021-700825    Tam Metin (PDF)

Myelodysplastic Syndrome in Children

Gül Nihal Özdemir

Myelodysplastic syndrome (MDS); is a clonal stem cell disorder characterized by cytopenia, dysplasia and ineffective erythropoiesis. MDS is very rare in children compared to adults. In myelodysplastic syndrome, complaints related to cytopenia such as bleeding, infection, and pallor are the most common. Diagnosis is made through clinical findings, morphology, immunophenotype and cytogenetic methods. Unexplained prolonged cytopenia, dysplasia in at least one series, clonal cytogenetic anomaly and increased blasts are diagnostic criteria, and the presence of at least two guides diagnosis. There are important differences between childhood and adult MDS in terms of classification, underlying diseases and treatment approaches. In this article, MDS in childhood is described by comparing it with adult MDS.

Anahtar Kelimeler: Myelodysplastic syndrome, Child, Dysplasia, Cytopenia

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Referanslar

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APA

Özdemir, G.N. (2021). Çocuklarda Miyelodisplastik Sendrom. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 4(2), 75-80. https://doi.org/10.26650/JARHS2021-700825


AMA

Özdemir G N. Çocuklarda Miyelodisplastik Sendrom. Sağlık Bilimlerinde İleri Araştırmalar Dergisi. 2021;4(2):75-80. https://doi.org/10.26650/JARHS2021-700825


ABNT

Özdemir, G.N. Çocuklarda Miyelodisplastik Sendrom. Sağlık Bilimlerinde İleri Araştırmalar Dergisi, [Publisher Location], v. 4, n. 2, p. 75-80, 2021.


Chicago: Author-Date Style

Özdemir, Gül Nihal,. 2021. “Çocuklarda Miyelodisplastik Sendrom.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 4, no. 2: 75-80. https://doi.org/10.26650/JARHS2021-700825


Chicago: Humanities Style

Özdemir, Gül Nihal,. “Çocuklarda Miyelodisplastik Sendrom.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi 4, no. 2 (Mar. 2025): 75-80. https://doi.org/10.26650/JARHS2021-700825


Harvard: Australian Style

Özdemir, GN 2021, 'Çocuklarda Miyelodisplastik Sendrom', Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 4, no. 2, pp. 75-80, viewed 22 Mar. 2025, https://doi.org/10.26650/JARHS2021-700825


Harvard: Author-Date Style

Özdemir, G.N. (2021) ‘Çocuklarda Miyelodisplastik Sendrom’, Sağlık Bilimlerinde İleri Araştırmalar Dergisi, 4(2), pp. 75-80. https://doi.org/10.26650/JARHS2021-700825 (22 Mar. 2025).


MLA

Özdemir, Gül Nihal,. “Çocuklarda Miyelodisplastik Sendrom.” Sağlık Bilimlerinde İleri Araştırmalar Dergisi, vol. 4, no. 2, 2021, pp. 75-80. [Database Container], https://doi.org/10.26650/JARHS2021-700825


Vancouver

Özdemir GN. Çocuklarda Miyelodisplastik Sendrom. Sağlık Bilimlerinde İleri Araştırmalar Dergisi [Internet]. 22 Mar. 2025 [cited 22 Mar. 2025];4(2):75-80. Available from: https://doi.org/10.26650/JARHS2021-700825 doi: 10.26650/JARHS2021-700825


ISNAD

Özdemir, GülNihal. “Çocuklarda Miyelodisplastik Sendrom”. Sağlık Bilimlerinde İleri Araştırmalar Dergisi 4/2 (Mar. 2025): 75-80. https://doi.org/10.26650/JARHS2021-700825



ZAMAN ÇİZELGESİ


Gönderim10.03.2020
Kabul20.01.2021
Çevrimiçi Yayınlanma19.06.2021

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