This study examines the aesthetic and thematic parallels between visual arts and music during the Renaissance from an interdisciplinary perspective. Its aim is to explore how aesthetic values and thematic elements are reflected concurrently across both art forms. Initially, an analysis of Leonardo da Vinci’s The Virgin of the Rocks and Josquin des Prez’s Ave Maria… Virgo Serena reveals key Renaissance ideals such as harmony, balance, and humanism. Subsequently, a comparative examination of Sandro Botticelli’s The Adoration of the Magi and Claudio Monteverdi’s Vespro della Beata Vergine, alongside Raphael’s The Sistine Madonna and Giovanni Pierluigi da Palestrina’s Missa Papae Marcelli, is undertaken. Visual and auditory techniques including sfumato, perspective, polyphony, and rhythmic structuresare shown to converge around the ideal of "harmony within continuity," guiding the perception of both viewer and listener. Furthermore, within the framework of paragone debates, the ways in which painting and music enriched each other's expressive capacities are explored. The findings emphasize the coordinated role of visual and auditory arts in shaping the spiritual experience of the Renaissance individual. Future research could offer new insights by examining this interdisciplinary interaction across different historical and cultural contexts.