References

• Saleh IM, Ruyter IE, Haapasalo M, 0rstavik D. Bacterial penetration along different root canal filling materials in the presence or absence of smear layer. Int Endod J 2008; 41: 32-40. google scholar
• Kakehashi S, Stanley HR, Fitzgerald RJ. The effects of surgical exposures of dental pulps in germ-free and conventional laboratory rats. Oral Surg Oral Med Oral Pathol 1965; 20: 3409. google scholar
• Baruwa AO, Martins JNR, Maravic T, Mazzitelli C, Mazzoni A, Ginjeira A. Effect of Endodontic Irrigating Solutions on Radicular Dentine Structure and Matrix Metalloproteinases-A Comprehensive Review. Dent J (Basel) 2022; 10: 219. google scholar
• Sen BH, Wesselink PR, Türkün M. The smear layer: a phenomenon in root canal therapy. Int Endod J 1995; 28: 141-8. google scholar
• Grigoratos D, Knowles J, Ng YL, Gulabivala K. Effect of exposing dentine to sodium hypochlorite and calcium hydroxide on its flexural strength and elastic modulus. Int Endod J 2001; 34: 113-9. google scholar
• Zehnder M, Schicht O, Sener B, Schmidlin P. Reducing surface tension in endodontic chelator solutions does not affect their ability to remove calcium from instrumented root canals. J Endod 2005; 31: 590-2. google scholar
• Grande NM, Plotino G, Falanga A, Pomponi M, Somma F. Interaction between EDTA and sodium hypochlorite: a nuclear magnetic resonance analysis. J Endod 2006;32:460-4. google scholar
• Lui JN, Kuah HG, Chen NN. Effect of EDTA with and without surfactants or ultrasonics on removal of smear layer. J Endod 2007;33:472-5. google scholar
• Sayin T, Serper A, Cehreli ZC, Kalayci S. Calcium loss from root canal dentin following EDTA, EGTA, and tetracycline-HCl treatment with or without subsequent NaOCl irrigation. J Endod 2007;33:581- 4. google scholar
• Ballal NV, Kandian S, Mala K, Bhat KS, Acharya S. Comparison of the efficacy of maleic acid and ethylenediaminetetraacetic acid in smear layer removal from instrumented human root canal: a scanning electron microscopic study. J Endod 2009;35:1573-6. google scholar
• van Rensburg CE, van Straten A, Dekker J. An in vitro investigation of the antimicrobial activity of oxifulvic acid. J Antimicrob Chemother 2000;46:847-63. google scholar
• Sherry L, Jose A, Murray C, Williams C, Jones B, Millington O, Bagg J, Ramage G. Carbohydrate Derived Fulvic Acid: An in vitro Investigation of a Novel Membrane Active Antiseptic Agent Against Candida albicans Biofilms. Front Microbiol 2012;3:116. google scholar
• Sabi R, Vrey P, van Rensburg CE. Carbohydrate-derived Fulvic acid (CHD-FA) inhibits Carrageenan-induced inflammation and enhances wound healing: efficacy and Toxicity study in rats. Drug Development Research 2012;73:18-23. google scholar
• Rodriguez NC, Urrutia EC, Gertrudis BH, Chaverri JP, Mejıa GB. Antioxidant activity of fulvic acid: A living matter-derived bioactive compound. J Food Agric Environ 2011;9:123-7. google scholar
• Arun DR, Sujatha V, Mahalaxmi S. Effect of 5% Carbohydrate Derived-Fulvic Acid on Smear Layer Removal and Root Dentin Microhardness - An In Vitro study. Eur Endod J 2022;7:156-60. google scholar
• Machnick TK, Torabinejad M, Munoz CA, Shabahang S. Effect of MTAD on flexural strength and modulus of elasticity of dentin. J Endod 2003;29:747-50. google scholar
• Peters OA, Schönenberger K, Laib A. Effects of four Ni-Ti preparation techniques on root canal geometry assessed by micro computed tomography. Int Endod J 2001;34:221-30. google scholar
• Souza EM, Calixto AM, Lima CN, Pappen FG, De-Deus G. Similar influence of stabilized alkaline and neutral sodium hypochlorite solutions on the fracture resistance of root canal-treated bovine teeth. J Endod 2014;40:1600-3. google scholar
• Sim TP, Knowles JC, Ng YL, Shelton J, Gulabivala K. Effect of sodium hypochlorite on mechanical properties of dentine and tooth surface strain. Int Endod J 2001;34:120-32. google scholar
• Dunavant TR, Regan JD, Glickman GN, et al. Comparative evaluation of endodontic irrigants against Enterococcus faecalis biofilms. J Endod 2006;32:527-31. google scholar
• Dua A, Dua D, Uppin VM. Evaluation of the effect of duration of application of Smear Clear in removing intracanal smear layer: SEM study. Saudi Endod J 2015;5:26-32. google scholar
• Ballal NV, Mala K, Bhat KS. Evaluation of the effect of maleic acid and ethylenediaminetetraacetic acid on the microhardness and surface roughness of human root canal dentin. J Endod 2010; 36:1385-8. google scholar
• Schepetkin IA, Khlebnikov AI, Ah SY, Woo SB, Jeong CS, Klubachuk ON, Kwon BS. Characterization and biological activities of humic substances from mumie. J Agric Food Chem 2003;51:5245-54. google scholar
• Gandy JJ, Snyman JR, van Rensburg CE. Randomized, parallel-group, double-blind, controlled study to evaluate the efficacy and safety of carbohydrate-derived fulvic acid in topical treatment of eczema. Clin Cosmet Investig Dermatol 2011;4:145-8. google scholar
• Rawel HM, Czajka D, Rohn S, Kroll J. Interactions of different phenolic acids and flavonoids with soy proteins. Int J Biol Macromol 2002 ;30:137-50. google scholar
• Huang TJ, Schilder H, Nathanson D. Effects of moisture content and endodontic treatment on some mechanical properties of human dentin. J Endod 1992;18:209-15. google scholar
• Patterson SS. In vivo and in vitro studies of the effect of the disodium slat of ethylenediamine tetra-acetate on human dentine and its endodontic implications. Oral Surg Oral Med Oral Pathol. 1963;16:83-103. google scholar
• Patil P, Banga KS, Pawar AM, Pimple S, Ganeshan R. Influence of root canal obturation using gutta-percha with three different sealers on root reinforcement of endodontically treated teeth. An in vitro comparative study of mandibular incisors. J Conserv Dent 2017;20:241-4. google scholar
• Marending M, Paque F, Fischer J, Zehnder M. Impact of irrigant sequence on mechanical properties of human root dentin. J Endod 2007;33:1325-8. google scholar
• Hiradate S, Yonezawa T, Takesako H. Isolation and purification of hydrophilic fulvic acids by precipitation. Geoderma 2006;1:196-205. google scholar
• Prasansuttiporn T, Nakajima M, Kunawarote S, Foxton RM, Tagami J. Effect of reducing agents on bond strength to NaOCl-treated dentin. Dent Mater 2011;27:229-34. google scholar
• Bedran-Russo AK, Pashley DH, Agee K, Drummond JL, Miescke KJ. Changes in stiffness of demineralized dentin following application of collagen crosslinkers. J Biomed Mater Res B Appl Biomater 2008;86:330-4. google scholar
• Epasinghe DJ, Yiu CK, Burrow MF, Tsoi JK, Tay FR. Effect of flavonoids on the mechanical properties of demineralised dentine. J Dent 2014;42:1178-84. google scholar
• Matos AB, Palma RG, Saraceni CH, Matson E. Effects of acid etching on dentin surface: SEM morphological study. Braz Dent J 1997;8:35-41. google scholar
• Durmus B, Hale AA, Oguz E, Sema B. The effect of different irrigation protocols on elastic modulus of dentine and biomechanics of single-rooted premolar tooth: A nano-indentation and finite element analysis study. Niger J Clin Pract 2019; 22:101-7. google scholar
• Ferrer-Luque CM, Arias-Moliz MT, Gonzalez-Rodriguez MP, Baca P. Antimicrobial activity of maleic acid and combinations of cetrimide with chelating agents against Enterococcus faecalis biofilm. J Endod 2010;36:1673-5. google scholar
• Saito K, Webb TD, Imamura GM, Goodell GG. Effect of shortened irrigation times with 17% ethylene diamine tetra-acetic acid on smear layer removal after rotary canal instrumentation. J Endod 2008;34:1011-4. google scholar

Citations