Journal of Advanced Research in Health Sciences

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DOI :10.26650/JARHS2024-1473193   IUP :10.26650/JARHS2024-1473193    Full Text (PDF)

ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS

Gönül Şeyda Seydel, İnayet Güntürk, Cevat Yazıcı, Füsun Ferda Erdoğan

Objective: The aim of this study was to examine the association between gustatory and olfactory dysfunctions and ghrelin, IL-6, and IL-10 levels in patients with COVID-19.

Materials and Methods: A total of 80 COVID-19 patients were enrolled in the study: 57 patients with gustatory and/or olfactory dysfunctions and 23 patients without gustatory or olfactory dysfunctions. The plasma ghrelin, IL-6, and IL-10 levels of all patients were determined using the ELISA method.

Results: COVID-19 patients with gustatory and/or olfactory dysfunctions had higher IL-6 and lower ghrelin and IL-10 levels compared with COVID19 patients without gustatory or olfactory dysfunctions (p<0.001).

Conclusions: These results demonstrate that an inflammatory process mediated by ghrelin, IL-6, and IL-10 contributes to the development of gustatory and olfactory dysfunctions in COVID-19 patients.

Keywords: Ghrelin, IL-6, IL-10, COVID-19, Gustatory dysfunction, Olfactory dysfunction
DOI :10.26650/JARHS2024-1473193   IUP :10.26650/JARHS2024-1473193    Full Text (PDF)

COVID-19’LU HASTALARDA TAT VE KOKU ALMA BOZUKLUKLARI İLE GHRELİN, IL-6 VE IL-10 DÜZEYLERİ ARASINDAKİ İLİŞKİ

Gönül Şeyda Seydel, İnayet Güntürk, Cevat Yazıcı, Füsun Ferda Erdoğan

Amaç: Bu çalışmanın amacı, COVID-19’lu hastalarda tat ve koku alma bozuklukları ile ghrelin, IL-6 ve IL-10 düzeyleri arasındaki ilişkiyi incelemekti.

Gereç ve Yöntemler: Çalışmaya tat ve/veya koku alma bozukluğu olan 57 hasta ve tat ve ya koku alma bozukluğu olmayan 23 hasta olmak üzere toplam 80 COVID-19 hasta dahil edildi. Tüm hastaların plazma ghrelin, IL-6 ve IL-10 düzeyleri ELISA yöntemi kullanılarak belirlendi.

Bulgular: Tat ve/veya koku alma bozukluğu olan COVID-19 hastaları, tat ve koku alma bozukluğu olmayan COVID-19 hastalarına kıyasla daha yüksek IL-6 ve daha düşük ghrelin ve IL-10 düzeylerine sahipti (p<0.001).

Sonuçlar: Bu sonuçlar, ghrelin, IL-6 ve IL-10’un aracılık ettiği inflamatuar bir sürecin, COVID-19 hastalarında tat ve koku alma bozukluklarının gelişimine katkıda bulunduğunu göstermektedir.

Keywords: Ghrelin, IL-6, IL-10, COVID-19, tat alma bozukluğu, koku alma bozukluğu

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APA

Seydel, G.Ş., Güntürk, İ., Yazıcı, C., & Erdoğan, F.F. (2024). ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS. Journal of Advanced Research in Health Sciences, 7(3), 209-213. https://doi.org/10.26650/JARHS2024-1473193


AMA

Seydel G Ş, Güntürk İ, Yazıcı C, Erdoğan F F. ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS. Journal of Advanced Research in Health Sciences. 2024;7(3):209-213. https://doi.org/10.26650/JARHS2024-1473193


ABNT

Seydel, G.Ş.; Güntürk, İ.; Yazıcı, C.; Erdoğan, F.F. ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS. Journal of Advanced Research in Health Sciences, [Publisher Location], v. 7, n. 3, p. 209-213, 2024.


Chicago: Author-Date Style

Seydel, Gönül Şeyda, and İnayet Güntürk and Cevat Yazıcı and Füsun Ferda Erdoğan. 2024. “ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS.” Journal of Advanced Research in Health Sciences 7, no. 3: 209-213. https://doi.org/10.26650/JARHS2024-1473193


Chicago: Humanities Style

Seydel, Gönül Şeyda, and İnayet Güntürk and Cevat Yazıcı and Füsun Ferda Erdoğan. “ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS.” Journal of Advanced Research in Health Sciences 7, no. 3 (Nov. 2024): 209-213. https://doi.org/10.26650/JARHS2024-1473193


Harvard: Australian Style

Seydel, GŞ & Güntürk, İ & Yazıcı, C & Erdoğan, FF 2024, 'ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS', Journal of Advanced Research in Health Sciences, vol. 7, no. 3, pp. 209-213, viewed 15 Nov. 2024, https://doi.org/10.26650/JARHS2024-1473193


Harvard: Author-Date Style

Seydel, G.Ş. and Güntürk, İ. and Yazıcı, C. and Erdoğan, F.F. (2024) ‘ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS’, Journal of Advanced Research in Health Sciences, 7(3), pp. 209-213. https://doi.org/10.26650/JARHS2024-1473193 (15 Nov. 2024).


MLA

Seydel, Gönül Şeyda, and İnayet Güntürk and Cevat Yazıcı and Füsun Ferda Erdoğan. “ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS.” Journal of Advanced Research in Health Sciences, vol. 7, no. 3, 2024, pp. 209-213. [Database Container], https://doi.org/10.26650/JARHS2024-1473193


Vancouver

Seydel GŞ, Güntürk İ, Yazıcı C, Erdoğan FF. ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS. Journal of Advanced Research in Health Sciences [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];7(3):209-213. Available from: https://doi.org/10.26650/JARHS2024-1473193 doi: 10.26650/JARHS2024-1473193


ISNAD

Seydel, GönülŞeyda - Güntürk, İnayet - Yazıcı, Cevat - Erdoğan, FüsunFerda. “ASSOCIATION BETWEEN GUSTATORY AND OLFACTORY DYSFUNCTIONS AND GHRELIN, IL-6, AND IL-10 LEVELS IN COVID-19 PATIENTS”. Journal of Advanced Research in Health Sciences 7/3 (Nov. 2024): 209-213. https://doi.org/10.26650/JARHS2024-1473193



TIMELINE


Submitted24.04.2024
Accepted05.09.2024
Published Online25.10.2024

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