Journal of Child

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DOI :10.5222/j.child.2019.18942   IUP :10.5222/j.child.2019.18942    Full Text (PDF)

Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre

Utkucan Uçkun, Firdevs Baş, Şükran Poyrazoğlu, Nur Mine Şükür, Fatma Feyza Darendeliler, Rüveyde Bundak

Objective: The aim of this study was to describe the characteristics and the etiological profile of children with severe short stature evaluated at a tertiary Pediatric Endocrinology centre in Istanbul. Method: Randomly selected 500 patients with the diagnosis of severe short stature height SDS<-3SD) were selected for this study. Among those, 320 patients with at least 12 months of follow-up were included. Results: Among these patients pathological short stature was diagnosed in 94.1%. Endocrine disorders (50.9%) was found to be the leading cause among pathological short stature; followed by specific syndromes and chromosomal abnormalities (13.2%), disproportionate short stature (12.8%), chronic diseases and malnutrition (12.8%), small for gestational age (SGA) with failure of catch-up growth (3.8%) and psychosocial short stature (0.6%). Of those with endocrine disorders; the most common etiology was growth hormone deficiency (GHD) (95.2%). Conclusion: Pathological causes should be ruled out in children with severe short stature. Our results showed that the most common cause was GHD among all subjects.

Keywords: : Severe short stature, children, etiology, growth hormone deficincy
DOI :10.5222/j.child.2019.18942   IUP :10.5222/j.child.2019.18942    Full Text (PDF)

Üçüncü Basamak Bir Pediatrik Endokrinoloji Merkezinde İzlenen Ağır Boy Kısalığı Vakalarının Etiyolojik Değerlendirmesi

Utkucan Uçkun, Firdevs Baş, Şükran Poyrazoğlu, Nur Mine Şükür, Fatma Feyza Darendeliler, Rüveyde Bundak

Amaç: Araştırmamızın amacı İstanbul’da üçüncü basamak bir Pediatrik Endokrinoloji merkezinde izlenen ağır boy kısalığı olgularının etiyolojik profilini ve karakteristiklerini incelemektir. Yöntem: Rastgele seçilen 500 ağır boy kısalığı (boy SDS <-3SD) vakasından izlem süresi 12 ay ve üzeri olan 320 hasta çalışmaya alınmıştır. Bulgular: Vakaların %94.1’inde patolojik boy kısalığı saptanmıştır. Patolojik boy kısalıklarında en sık etiyolojik neden endokrin bozukluklar (%50,9) olarak saptanmıştır. Bunu sırasıyla spesifik sendromlar ve kromozom anomalileri (%13,2), orantısız boy kısalıkları (%12,8), kronik hastalıklar ve malnütrisyon (%12,8), catch-up büyümeyi yakalayamayan gebelik yaşına göre küçük (SGA) vakalar (%3,8) ve psikososyal boy kısalığı (%0,6) izlemektedir. Endokrin bozukluklar içinde en sık etiyolojik neden büyüme hormonu eksikliğidir (%95,2). Sonuç: Ağır boy kısalığı olan çocuklarda patolojik boy kısalığı nedenleri dışlanmalıdır. Araştırmamız ağır boy kısalığı olgularında en sık etiyolojik nedenin endokrin bozukluklar olduğunu göstermiştir. Gerek tüm olgularda gerek de endokrin bozukluklar içinde en sık etiyolojik neden büyüme hormonu eksikliği olarak saptanmıştır.

Keywords: Ağır boy kısalığı, çocuklar, etiyoloji, büyüme hormonu eksikliği

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APA

Uçkun, U., Baş, F., Poyrazoğlu, Ş., Şükür, N.M., Darendeliler, F.F., & Bundak, R. (2019). Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Journal of Child, 19(2), 63-76. https://doi.org/10.5222/j.child.2019.18942


AMA

Uçkun U, Baş F, Poyrazoğlu Ş, Şükür N M, Darendeliler F F, Bundak R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Journal of Child. 2019;19(2):63-76. https://doi.org/10.5222/j.child.2019.18942


ABNT

Uçkun, U.; Baş, F.; Poyrazoğlu, Ş.; Şükür, N.M.; Darendeliler, F.F.; Bundak, R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Journal of Child, [Publisher Location], v. 19, n. 2, p. 63-76, 2019.


Chicago: Author-Date Style

Uçkun, Utkucan, and Firdevs Baş and Şükran Poyrazoğlu and Nur Mine Şükür and Fatma Feyza Darendeliler and Rüveyde Bundak. 2019. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre.” Journal of Child 19, no. 2: 63-76. https://doi.org/10.5222/j.child.2019.18942


Chicago: Humanities Style

Uçkun, Utkucan, and Firdevs Baş and Şükran Poyrazoğlu and Nur Mine Şükür and Fatma Feyza Darendeliler and Rüveyde Bundak. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre.” Journal of Child 19, no. 2 (Nov. 2024): 63-76. https://doi.org/10.5222/j.child.2019.18942


Harvard: Australian Style

Uçkun, U & Baş, F & Poyrazoğlu, Ş & Şükür, NM & Darendeliler, FF & Bundak, R 2019, 'Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre', Journal of Child, vol. 19, no. 2, pp. 63-76, viewed 15 Nov. 2024, https://doi.org/10.5222/j.child.2019.18942


Harvard: Author-Date Style

Uçkun, U. and Baş, F. and Poyrazoğlu, Ş. and Şükür, N.M. and Darendeliler, F.F. and Bundak, R. (2019) ‘Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre’, Journal of Child, 19(2), pp. 63-76. https://doi.org/10.5222/j.child.2019.18942 (15 Nov. 2024).


MLA

Uçkun, Utkucan, and Firdevs Baş and Şükran Poyrazoğlu and Nur Mine Şükür and Fatma Feyza Darendeliler and Rüveyde Bundak. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre.” Journal of Child, vol. 19, no. 2, 2019, pp. 63-76. [Database Container], https://doi.org/10.5222/j.child.2019.18942


Vancouver

Uçkun U, Baş F, Poyrazoğlu Ş, Şükür NM, Darendeliler FF, Bundak R. Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre. Journal of Child [Internet]. 15 Nov. 2024 [cited 15 Nov. 2024];19(2):63-76. Available from: https://doi.org/10.5222/j.child.2019.18942 doi: 10.5222/j.child.2019.18942


ISNAD

Uçkun, Utkucan - Baş, Firdevs - Poyrazoğlu, Şükran - Şükür, NurMine - Darendeliler, FatmaFeyza - Bundak, Rüveyde. “Etiologic Evaluation of Severe Short Stature in Children at a Tertiary Pediatric Endocrinology Centre”. Journal of Child 19/2 (Nov. 2024): 63-76. https://doi.org/10.5222/j.child.2019.18942



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Published Online31.08.2019

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