Journal of Child

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Case Report


DOI :10.5222/j.child.2012.083   IUP :10.5222/j.child.2012.083    Full Text (PDF)

Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma

Erkin Rahimov, Barış Ekici, Meliha Mine Çalışkan

Acute ataxia in infants may develop due to viral infections, drug intoxication, intercranial lesions. One of the first symptoms of neuroblastoma can be the combination of acute cerebral ataxia, and opsomyoclonus. A 19-month old male infant was admitted with complaints of ataxia, loss of balance and hand tremors. The neuron-specific enolase test revealed an increased level of 48 ng/ml (the normal level being <16 ng/ml), and spinal MRI revealed a hyperintense T2 signal mass that absorbed the contrast on the 7 - 9 dorsal vertebral levels. During his investigation, he developed opsomyoclonus. He was diagnosed as a Stage 1 neuroblastoma and no chemotherapy was approved. After the surgery, the patient’s tremors, ataxia and opsomyoclonus continued. After the patient was put on steroids, opsomyoclonus subsided, but the ataxia persisted. Opsomyoclonus in pediatric patients with neuroblastoma is among good prognostic criteria, but it could cause permanent neurological deficits.

Keywords: Neuroblastoma, ataxia, Opsoclonus-Myoclonus syndrome
DOI :10.5222/j.child.2012.083   IUP :10.5222/j.child.2012.083    Full Text (PDF)

Opsomiyoklonus ve Ataksi: Nöroblastomun Kalıcı Olabilen Nörolojik Sorunu

Erkin Rahimov, Barış Ekici, Meliha Mine Çalışkan

Sütçocuğu döneminde akut ataksi çoğu kez viral infeksiyonlar, ilaç intoksikasyonları ve intrakraniyal tümörlere bağlı olarak gelişir. Akut serebellar ataksi ve opsomiyoklonus birlikteliği nöroblastomun ilk belirtisi olabilir. On dokuz aylık erkek hasta, 10 gün önce başlayan yürürken düşme, dengesizlik ve ellerde titreme yakınmaları ile getirildi. Hastanın nöron spesifik enolaz değeri 48 ng/ml (normal değeri < 16 ng/ml) idi. Spinal manyetik rezonans görüntülemesinde torakal 7-9 vertebralar seviyesinde, T2 kesitlerde hiperintens kontrast tutulumu gösteren oval kitle saptandı. İzleminde hastada opsomiyoklonus gelişti. Histopatolojik inceleme nöroblastom ile uyumlu bulundu. Tümör evre 1 olarak değerlendirilip kemoterapiye gerek duyulmadı. Ameliyat sonrası hastanın tremor, ataksi ve opsomiyoklonusu devam etmesi üzerine steroid tedavisi başlandı. Bu tedaviyle opsomiyoklonusu kayboldu, fakat ataksisi devam etti. Nöroblastomda opsomiyoklonus her ne kadar iyi prognostik kriterler arasında yer alsa da tedavi sonrası kalıcı nörolojik sorunlara yol açabilmektedir.

Keywords: Nöroblastoma, ataksi, Opsoklonus-Miyoklonus sendromu

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APA

Rahimov, E., Ekici, B., & Çalışkan, M.M. (2012). Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma. Journal of Child, 12(2), 83-85. https://doi.org/10.5222/j.child.2012.083


AMA

Rahimov E, Ekici B, Çalışkan M M. Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma. Journal of Child. 2012;12(2):83-85. https://doi.org/10.5222/j.child.2012.083


ABNT

Rahimov, E.; Ekici, B.; Çalışkan, M.M. Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma. Journal of Child, [Publisher Location], v. 12, n. 2, p. 83-85, 2012.


Chicago: Author-Date Style

Rahimov, Erkin, and Barış Ekici and Meliha Mine Çalışkan. 2012. “Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma.” Journal of Child 12, no. 2: 83-85. https://doi.org/10.5222/j.child.2012.083


Chicago: Humanities Style

Rahimov, Erkin, and Barış Ekici and Meliha Mine Çalışkan. “Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma.” Journal of Child 12, no. 2 (May. 2025): 83-85. https://doi.org/10.5222/j.child.2012.083


Harvard: Australian Style

Rahimov, E & Ekici, B & Çalışkan, MM 2012, 'Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma', Journal of Child, vol. 12, no. 2, pp. 83-85, viewed 23 May. 2025, https://doi.org/10.5222/j.child.2012.083


Harvard: Author-Date Style

Rahimov, E. and Ekici, B. and Çalışkan, M.M. (2012) ‘Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma’, Journal of Child, 12(2), pp. 83-85. https://doi.org/10.5222/j.child.2012.083 (23 May. 2025).


MLA

Rahimov, Erkin, and Barış Ekici and Meliha Mine Çalışkan. “Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma.” Journal of Child, vol. 12, no. 2, 2012, pp. 83-85. [Database Container], https://doi.org/10.5222/j.child.2012.083


Vancouver

Rahimov E, Ekici B, Çalışkan MM. Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma. Journal of Child [Internet]. 23 May. 2025 [cited 23 May. 2025];12(2):83-85. Available from: https://doi.org/10.5222/j.child.2012.083 doi: 10.5222/j.child.2012.083


ISNAD

Rahimov, Erkin - Ekici, Barış - Çalışkan, MelihaMine. “Opsomyoclonus and Ataxia: Possibly Permanent Neurological Conditions Caused by Neuroblastoma”. Journal of Child 12/2 (May. 2025): 83-85. https://doi.org/10.5222/j.child.2012.083



TIMELINE


First Revision14.12.2011
Last Revision28.04.2012
Published Online28.04.2012

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