Research Article


DOI :10.26650/oba.1602650   IUP :10.26650/oba.1602650    Full Text (PDF)

The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine

Ahmet NizamoğluArif Hüdai KökenHüseyin İlter

Abdülhamid II’s interest in medicine and health initiated relations with Louis Pasteur. The scientific contacts and achievements established on this axis were turned into a policy by order of the sultan. The interaction between Abdülhamid II and Pasteur, which started in the last quarter of the 19th century, can be said to have created an infrastructure for the current scientifically based health policies in terms of public health and preventive medicine practices that have continued from the Ottoman Empire to the present day. The process initiated by Abdülhamid II, in line with his relations with Pasteur and the Pasteur Institute, paved the way for a more effective fight against other infectious diseases such as rabies, anthrax, smallpox, and diphtheria. In this study, Abdülhamid II’s relations with Pasteur and the Pasteur Institute, which formed the basis of modern public health policies, were evaluated in the light of archival documents, printed works, periodicals, statistical reports, and copyrighted works. The study was conducted using the survey model and document analysis method.

DOI :10.26650/oba.1602650   IUP :10.26650/oba.1602650    Full Text (PDF)

II. Abdülhamid’in Pasteur ve Pasteur Enstitüsü ile Olan Münasebetlerinin Osmanlı Tıbbına Etkileri

Ahmet NizamoğluArif Hüdai KökenHüseyin İlter

II. Abdülhamid’in tıp ve sağlığa ilgisi Louis Pasteur ile olan münasebetleri başlatmıştır. Bu eksende kurulan bilimsel temaslar ve kazanımlar padişah emriyle bir politika haline getirilmiştir. 19. yüzyılın son çeyreğinde başlayan II. Abdülhamid ile Pasteur etkileşimi, güncel bilimsel temele dayanan sağlık politikalarının Osmanlı’dan günümüze kadar devam eden halk sağlığı ve koruyucu hekimlik uygulamaları yönüyle bir alt yapı oluşturduğu söylenebilir. II. Abdülhamid’in Pasteur ve Pasteur Enstitüsü ile münasebetleri doğrultusunda başlattığı süreç, kuduz, şarbon, çiçek, difteri gibi diğer bulaşıcı hastalıklarla mücadelenin daha etkin bir şekilde yürütülmesine ön ayak olmuştur. Bu çalışmada modern halk sağlığı politikalarının temelini oluşturan II. Abdülhamid’in, Pasteur ve Pasteur Enstitüsü ile olan münasebetleri arşiv belgeleri, döneme ait basılı eserler, süreli yayınlar, istatistik raporları ve telif-tetkik eserler ışığında değerlendirilmiştir. Çalışma tarama modeli ve doküman analizi yöntemiyle yapılmıştır


EXTENDED ABSTRACT


In the 19th century, developments in microbiology in the West highlighted the importance of preventive healthcare services. Alongside the emergence of modern approaches in state governance, state officials began to be held responsible for healthcare services and were authorized to take necessary measures for public health. These advancements also influenced the Ottoman Empire, leading to the modernization of administrative and healthcare practices concerning public health. Health reforms in the Ottoman Empire gained momentum during the reign of Sultan Abdulhamid II. A notable development was the implementation of vaccination programs, particularly against rabies and smallpox, to improve public health.

In addition to structural reforms in healthcare, Abdulhamid II prioritized the training and education of numerous physicians and healthcare personnel to address the healthcare needs of the time, especially concerning infectious diseases. He adopted an encouraging stance toward sending physicians and healthcare teams abroad for education. In the fall of 1885, Louis Pasteur’s introduction of the rabies vaccine to the scientific community caught the attention of Abdulhamid II, who closely followed healthcare advancements in Europe. Approximately seven months later, in the spring of 1886, he ordered a delegation to be sent to Paris to learn about the newly developed rabies vaccine from Louis Pasteur. The delegation was to include prominent experts such as Zoeros Pasha, Hüseyin Remzi, and Hüseyin Hüsnü, with Zoeros Pasha designated as the head. Even before their departure from Istanbul, the delegation attracted the attention of the French press and was featured in several newspapers. To honor Pasteur, Zoeros Pasha was entrusted with a sum of money and a medal to be presented to the newly established Pasteur Institute.

After receiving comprehensive training in Paris, the delegation returned to Istanbul and was tasked with implementing modern vaccination techniques against rabies. During Abdulhamid II\'s reign, physicians were sent to Europe not only to study rabies and diphtheria vaccines but also to learn methods for combating other infectious diseases. Institutional reforms in combating infectious diseases were realized upon the return of these trained physicians. The first rabies hospital, Dâülkelp Tedavihanesi, was established in Sirkeci Demirkapı by Zoeros Pasha in 1887. In 1892, the Telkihhane-i Şâhâne was founded to produce and develop smallpox vaccines. By 1893, the Bakteriyolojihane-i Şâhâne and Tebhirhaneler were established to produce the vaccines and serums needed to fight epidemics. 

The integration of medical knowledge into healthcare services, particularly concerning rabies and anthrax, was facilitated by those sent from Istanbul to train at the Pasteur Institute. Experts in their fields who received advanced training at this pioneering institution returned to Istanbul, paving the way for future overseas education opportunities for healthcare personnel in other areas. Statistical records of treatments provided valuable insights into the outcomes of efforts to combat infectious diseases, enabling the evaluation of healthcare policies\' success. These records demonstrated the effectiveness of implemented policies, which subsequently facilitated the expansion of preventive healthcare practices across Anatolia.

The physicians who implemented these successful healthcare policies were commended, boosting their motivation. Additionally, individuals from the Pasteur Institute who visited the Ottoman Empire had the opportunity to assess how their advancements were integrated into Ottoman healthcare policies in institutional and practical terms. Their feedback further contributed to the improvement of healthcare services.

This study, conducted using the survey model and document analysis method, utilized documents obtained from the Ottoman Archives, printed works from the period, periodicals, statistical reports, and original studies. Searches were conducted in the open-access Ottoman Archive catalog of the Presidency of the Republic of Turkey Directorate of State Archives, and relevant documents pertaining to the research topic were selected.

For obtaining printed works from the period, the Digital Archive and e-Resources of the Istanbul Metropolitan Municipality Atatürk Library, the e-Resources of Atatürk University Central Library, and the National Library Digital Library System were utilized. Foreign periodicals were accessed via Gallica, the digital library of the Bibliothèque Nationale de France, and its partners.

Sources written in Ottoman Turkish and French were translated into modern Turkish. All these documents were systematically examined, and the findings were analyzed and discussed.


PDF View

References

  • T.C. Cumhurbaşkanlığı Devlet Arşivleri Başkanlığı Osmanlı Arşivi (BOA), İstanbul. google scholar
  • Bab-ı Ali Evrak Odası (BEO.) 1296/97179, 1354/101495, 1635/122614, 271/20301, 282/21111, 316/23681, 373/27927, 571/42788, 779/58415, 795/59583. google scholar
  • Dahiliye Mektubi Kalemi (DH.MKT.) 171/11, 1384/17, 1386/50, 1409/49, 1517/60, 1540/63, 1558/100, 1560/78, 1562/91, 1825/40, 1827/116, 1974/31, 2069/35, 2375/34, 2418/93, 308/29, 1381/5, 1398/10, 1464/3, 1532/10, 1584/7. google scholar
  • Hariciye Tahrirat (HR.TH.) 67/73. google scholar
  • İrade Dahiliye (İ.DH.) 1010/79739, 1048/82322, 1063/83378, 1216/95213, 989/780067, 989/78144, 991/78260. google scholar
  • İrade Hususi (İ.HUS.) 16/124, 16/19, 16/81. google scholar
  • İrade Şura-yı Devlet (İ.ŞD.) 88/5264. google scholar
  • İrade Orman ve Maadin (İ.OM.) 2/31, 5/41, 9/29. google scholar
  • Meclis-i Vükela Mazbataları (MV.) 62/34. google scholar
  • Şura-yı Devlet (ŞD.) 365/66, 517/18, 528/12, 530/17. google scholar
  • Yıldız Hususi Maruzat (Y.A.HUS.) 280/52, 285/31, 293/37. google scholar
  • Yıldız Mütenevvi Maruzat (Y.MTV.) 25/1, 129/82, 194/108, 20/20, 203/129, 72/118, 75/61. google scholar
  • Yıldız Sıhhiye Nezareti Maruzatı (Y.PRK.SH.) 4/56. google scholar
  • Yıldız Mabeyn Evrakı ve Saray Görevlileri Maruzatı (Y.PRK.SGE.) 2/73. google scholar
  • Zabtiye Defterler (ZB.d.) 315, 316. google scholar
  • L’Eclaireur Du Gard, 6 Mai 1886. google scholar
  • L’Univers Illustre, 19 Juin 1886. google scholar
  • Le Petit Journal, 14 Janvier 1893. google scholar
  • Akpınar, Deniz. Erhan, Ertuğrul. Türkiye’de Bakteriyoloji Alanında Gelişmeler (1876-1938). İstanbul: Kutlu Yayınevi, 2020. google scholar
  • Aydın, Erdem. “19. Yüzyılda Osmanlı Sağlık Teşkilatlanması”, OTAM 15 (2004): 185-207. google scholar
  • Aykurt, Çetin. Aykurt, FiLiz. “II. AbdüLhamit’in Pasteur Enstitüsü iLe MünasebetLeri”, Uluslararası Söz, Sanat, Sağlık Sempozyumu, Ed. Yüksel TopaLoğLu, Barış B. Acar, Ayşe Nur Özdemir, Seda Çetin, 2016: 481-485. google scholar
  • Başustaoğlu, Ahmet. Osmanlı’dan Cumhuriyet’e Mikrobiyoloji Tarihimize Bakış 1850-1923. Ankara: Klinik Mikrobiyoloji Uzmanlık Derneği Yayınları, 2011. google scholar
  • CavaiLLon, Jean Marc. Sandra Legout, “Louis Pasteur: Between Myth and Reality”, Biomolecules 12/4 (2022): 1-22. google scholar
  • Çakır, Sinan. “BakteriyoLojihane-i Şahane’nin Kuruluşu ve Faaliyetleri”, Yüksek Lisans Tezi, Marmara Üniversitesi, 2006. google scholar
  • Çavdar, Necati. Karcı, EroL. “XIX. YüzyıL OsmanLı SağLık TeşkiLatLanması’na Dair BibLiyografik Bir Deneme”, Journal of Turkish Studies 9/4 (2014): 255-286. google scholar
  • Çavuş, Remzi. “II. Abdülhamid Döneminde Dâülkelp (Köpek Hastalığı-Kuduz) Tedavihanesi,” VAKANÜVİS- Uluslararası Tarih Araştırmaları Dergisi 2/1 (2017): 45-61. google scholar
  • ErtuğruL, Levent. Tıp Terimleri Sözlüğü. İstanbul: Akademi Yayıncılık; 2010-2011. google scholar
  • Gordon Y. C. Cheung, Justin S. Bae, MichaeL Otto, “Pathogenicity and viruLence of StaphyLococcus aureus”, Virulance 12/1 (2021): 547-569. google scholar
  • Gökmen, Ertan. “19. Yüzyılda OsmanLı Sağlık Görevlileri ve Emeklileri”, OTAM 52/3 (2022): 99-133. google scholar
  • HayırLıdağ, Mustafa. “Dr. Alexander Zoeros Pasha (1842-1917): One of The First Bacteriologists”, International Social Mentality and Researcher Thinkers Journal 8/63 (2022): 1548-1551. google scholar
  • İhsanoğlu, Ekmeleddin. Osmanlı Tıbbi Bilimler Literatürü Tarihi. Cilt II. (Ed. Ekmeleddin İhsanoğlu vd.), İstanbul: İslam Tarih, Sanat ve Kültür Araştırma Merkezi, 2008. google scholar
  • Jübile De M. Pasteur. Paris: Gauthier-Villars Et Fils, Imprimeurs-Libraires, 1893. google scholar
  • Kahya, Esin. “Fransa’da İhtisas Yapmış Olan Türk Hekimlerinden Bazıları”, Ankara Üniversitesi Dil ve Tarih-Coğrafya Fakültesi Dergisi 31/1-2 (1987): 245-262. google scholar
  • Karacaoğlu, Emre. “Doktor Hüseyin Remzi Bey (Ö.1896) Hayatı, Eserleri ve Bilimsel Bir Diyaloğu”, Mersin Üniversitesi Tıp Fakültesi Lokman Hekim Tıp Tarihi ve Folklorik Tıp Dergisi 5/2 (2015): 69-83. google scholar
  • Karacaoğlu, Emre. “Bakteriyolojihâne-i Şâhâne’nin İlk Müdürü Dr. Maurice Nicolle’e (1862-1932) Dâir Bazı Arşiv Belgeleri”, Türkiye Klinikleri Tıp Etiği-Hukuku-Tarihi Dergisi 23/2 (2015): 41-53. google scholar
  • Karacaoğlu, Emre. “Hüseyin Remzi Bey ve Hüseyin Hüsnü Bey’in ‘Mikrob’ Adlı Eseri ve Tıp Tarihimiz Açısından Önemi,” TürKiye KliniKleri Tıp Etiği-Hukuku-Tarihi Dergisi 22/2 (2014): 48-59. google scholar
  • Karacaoğlu, Emre. “Hüseyin Remzi Bey ve Hüseyin Hüsnü Bey’in Mikrob Adlı Yapıtı ve Türk Tıp Bilimine Katkıları”, Yüksek Lisans Tezi, Ankara Üniversitesi, 2013. google scholar
  • Karacaoğlu, Emre. “Kuduz Hastalığına Dâir İlk Kitabımız: Kuduz İlleti ve Tedâvîsi”, Türkiye Klinikleri J Med Ethics 23/3 (2015): 73-85. google scholar
  • Kılıç, Pelin İskender. “II. Abdülhamid Döneminde İstanbul’da Hastane Açma Girişimi ve Doktor Stecoulis”, History Studies International Journal of History 13/1 (2021): 187-199. google scholar
  • Köken, Arif Hüdai. Nizamoğlu, Ahmet, “Tanzimat’tan Cumhuriyet’in Kuruluşuna Kadar Osmanlı Sağlık Mevzuatına Genel Bir Bakış (1839-1922)”, Türkiye Klinikleri J Med Ethics 33/1 (2024): 23-37. google scholar
  • Mitchell, A. M. Mitchell, T. J. “Streptococcus pneumoniae: virulence factors and variation”, Clinical Microbiology and Infection, 16/5 (2010): 411-418. google scholar
  • Özbek, Erdal. Selahattin Atmaca, “Anaerop Bakteriler; İzolasyon, İdentifikasyon, Yeni Türlerin Oluşturduğu Hastalıklar” Turk Mikrobiyol Cemiy Derg 54/1 (2024): 1-14. google scholar
  • Özgün, Cihan. “OsmanLı Devleti’nin Son Zamanlarında Bir İlletle Yüzleşmek: Devletin Resmi Tutumu Bağlamında Dâü'l-kelb (Kuduz Hastalığı)”, Tarih incelemeleri Dergisi, XXXII/2 (2017): 491-529. google scholar
  • Qi, Weilin. Ma, Cheng. Yan, Yun. Huang, Jianbin. “Chirality manipulation of supramolecular self-assembly based on the host-guest chemistry of cyclodextrin”, Current Opinion in Colloid & Interface Science 56 (2021): 1-11. google scholar
  • Smith, Kendall A. “Louis Pasteur, The Father Of Immunology?,” Frontiers in Immunology 3 (2012): 1-10. google scholar
  • Subhi Edhem, Nevsal-i Baytarî, Dersaadet: Agop Matyosyan Matbaası, 1334. google scholar
  • Unat, Ekrem Kadri. “OsmanLı İmparatorluğu’nda Mikrobiyoloji Tarihçesi Üzerine Bir Deneme,” Mikrobiyoloji Bülteni 4/3 (1970): 159-175. google scholar
  • Unat, Ekrem Kadri. Osmanlı İmparatorluğunda Bakteriyoloji ve Viroloji. İstanbul: İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi Yayınları, 1970. google scholar
  • Vallery Radot, Rene. R.M.M Pasteur, Histoire d’un Savant Par Un Ignorant. Paris: J. Hetzel, 1883. google scholar
  • Yıldırım, Nuran. "BakteriyoLojihane-i Şahane’de Veteriner Bakteriyoloji 1893-1901”, ed. Abdullah Özen, I. Ulusal Veteriner Hekimliği Tarihi ve Mesleki Etik Sempozyumu, 2006: 171-184. google scholar
  • Yıldırım, Nuran. “II. Abdülhamid’in Saltanat Yıllarında Tıp, Sağlık ve Sosyal Yardım”, Bezmialem Aktüel 21 (2018): 28-33. google scholar
  • Yıldırım, Nuran. “Zoeros Paşa’nın Paris Dönüşü Takdim Ettiği Rapor”, Yeni Tıp Tarihi Araştırmaları 1 (1995): 91-97. google scholar
  • Yıldırım, Nuran. Ertin, Hakan. “1893-1895 İstanbul Kolera Salgınında Avrupalı Uzmanlar ve Osmanlı Devleti’nde Sağlık Modernizasyonuna google scholar
  • Katkıları,” Anadolu Kliniği Tıp Bilimleri Dergisi Özel Sayı (2020): 85-101. google scholar
  • Yıldırım, Nuran. Özaltay, Bülent. “Sultan II. Abdülhamid’in Sağlığı ve Sağlık Hizmetleri”, Sultan II. Abdülhamid ve Dönemi, Ed. Coşkun Yılmaz, (İstanbul: Sultanbeyli Belediyesi, 2012): 123-146. google scholar
  • Zoeros, Alexander. “Dâülkelb Ameliyâthânesi,” in Nevsal-i Âfiyet, C. 1, ed. Besim Ömer, İstanbul: Haz. Ahmet Zeki İzgöer, Sağlık Bilimleri Üniversitesi Tıp Tarihi Uygulama ve Araştırma Merkezi Yayını, 2020. google scholar
  • Zoeros, Alexander. Daü'l-kelb Ameliyathanesi, Dersaadet: Tahir Bey’in 40 Numaralı Matbaası, 1317. google scholar

Citations

Copy and paste a formatted citation or use one of the options to export in your chosen format


EXPORT



APA

Nizamoğlu, A., Köken, A.H., & İlter, H. (2025). The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine. Studies in Ottoman Science, 26(2), 334-363. https://doi.org/10.26650/oba.1602650


AMA

Nizamoğlu A, Köken A H, İlter H. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine. Studies in Ottoman Science. 2025;26(2):334-363. https://doi.org/10.26650/oba.1602650


ABNT

Nizamoğlu, A.; Köken, A.H.; İlter, H. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine. Studies in Ottoman Science, [Publisher Location], v. 26, n. 2, p. 334-363, 2025.


Chicago: Author-Date Style

Nizamoğlu, Ahmet, and Arif Hüdai Köken and Hüseyin İlter. 2025. “The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine.” Studies in Ottoman Science 26, no. 2: 334-363. https://doi.org/10.26650/oba.1602650


Chicago: Humanities Style

Nizamoğlu, Ahmet, and Arif Hüdai Köken and Hüseyin İlter. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine.” Studies in Ottoman Science 26, no. 2 (Aug. 2025): 334-363. https://doi.org/10.26650/oba.1602650


Harvard: Australian Style

Nizamoğlu, A & Köken, AH & İlter, H 2025, 'The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine', Studies in Ottoman Science, vol. 26, no. 2, pp. 334-363, viewed 29 Aug. 2025, https://doi.org/10.26650/oba.1602650


Harvard: Author-Date Style

Nizamoğlu, A. and Köken, A.H. and İlter, H. (2025) ‘The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine’, Studies in Ottoman Science, 26(2), pp. 334-363. https://doi.org/10.26650/oba.1602650 (29 Aug. 2025).


MLA

Nizamoğlu, Ahmet, and Arif Hüdai Köken and Hüseyin İlter. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine.” Studies in Ottoman Science, vol. 26, no. 2, 2025, pp. 334-363. [Database Container], https://doi.org/10.26650/oba.1602650


Vancouver

Nizamoğlu A, Köken AH, İlter H. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine. Studies in Ottoman Science [Internet]. 29 Aug. 2025 [cited 29 Aug. 2025];26(2):334-363. Available from: https://doi.org/10.26650/oba.1602650 doi: 10.26650/oba.1602650


ISNAD

Nizamoğlu, Ahmet - Köken, ArifHüdai - İlter, Hüseyin. The Influence of Abdulhamid II’s Relationship with Pasteur and the Pasteur Institute on Ottoman Medicine”. Studies in Ottoman Science 26/2 (Aug. 2025): 334-363. https://doi.org/10.26650/oba.1602650



TIMELINE


Submitted16.12.2024
Accepted07.05.2025
Published Online30.07.2025

LICENCE


Attribution-NonCommercial (CC BY-NC)

This license lets others remix, tweak, and build upon your work non-commercially, and although their new works must also acknowledge you and be non-commercial, they don’t have to license their derivative works on the same terms.


SHARE



Istanbul University Press aims to contribute to the dissemination of ever growing scientific knowledge through publication of high quality scientific journals and books in accordance with the international publishing standards and ethics. Istanbul University Press follows an open access, non-commercial, scholarly publishing.