European Journal of Biology

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Research Article


DOI :10.26650/EurJBiol.2019.0002   IUP :10.26650/EurJBiol.2019.0002    Full Text (PDF)

Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis

Sehkar Oktay, Özge Ozoner, Ebru Emekli Alturfan, Ülkü Noyan

Objective: Periodontitis, an inflammatory disease, leads to the destruction of the periodontium and results in tooth loss. Reactive oxygen species are involved in the destruction of periodontal tissues and systemic inflammation. The aim of the study was to evaluate and compare the oxidative status in different kinds of periodontal disease and whether the treatment amends these effects.
Materials and Methods: Whole saliva was collected from 30 patients with chronic marginal gingivitis, chronic periodontitis and generalized aggressive periodontitis at baseline and after non-surgical periodontal therapy and 10 healthy control subjects. Lipid peroxidation (LPO) and glutathione (GSH) levels and glutathione-s-transferase, superoxide dismutase catalase and tissue factor (TF) activities were determined in the whole saliva.
Results: Antioxidant enzyme activities were significantly higher in periodontitis groups before non-surgical periodontal therapy and also increased LPO levels and decreased TF activities were found in these groups. Significant decreases in antioxidant enzymes and LPO levels, and increases in TF activities were detected after treatment. GSH levels increased after treatment.
Conclusion: Increased antioxidant enzyme activities and LPO levels indicate destruction of periodontal tissues due to excessive radical production. Treatment of periodontitis and restoring the balance of oxidant-antioxidants ameliorates tissue damage caused by oxygen species and inflammation.
Keywords: Oxidative stress, periodontitis, saliva

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APA

Oktay, S., Ozoner, Ö., Emekli Alturfan, E., & Noyan, Ü. (2019). Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis. European Journal of Biology, 78(2), 63-68. https://doi.org/10.26650/EurJBiol.2019.0002


AMA

Oktay S, Ozoner Ö, Emekli Alturfan E, Noyan Ü. Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis. European Journal of Biology. 2019;78(2):63-68. https://doi.org/10.26650/EurJBiol.2019.0002


ABNT

Oktay, S.; Ozoner, Ö.; Emekli Alturfan, E.; Noyan, Ü. Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis. European Journal of Biology, [Publisher Location], v. 78, n. 2, p. 63-68, 2019.


Chicago: Author-Date Style

Oktay, Sehkar, and Özge Ozoner and Ebru Emekli Alturfan and Ülkü Noyan. 2019. “Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis.” European Journal of Biology 78, no. 2: 63-68. https://doi.org/10.26650/EurJBiol.2019.0002


Chicago: Humanities Style

Oktay, Sehkar, and Özge Ozoner and Ebru Emekli Alturfan and Ülkü Noyan. “Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis.” European Journal of Biology 78, no. 2 (Apr. 2024): 63-68. https://doi.org/10.26650/EurJBiol.2019.0002


Harvard: Australian Style

Oktay, S & Ozoner, Ö & Emekli Alturfan, E & Noyan, Ü 2019, 'Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis', European Journal of Biology, vol. 78, no. 2, pp. 63-68, viewed 26 Apr. 2024, https://doi.org/10.26650/EurJBiol.2019.0002


Harvard: Author-Date Style

Oktay, S. and Ozoner, Ö. and Emekli Alturfan, E. and Noyan, Ü. (2019) ‘Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis’, European Journal of Biology, 78(2), pp. 63-68. https://doi.org/10.26650/EurJBiol.2019.0002 (26 Apr. 2024).


MLA

Oktay, Sehkar, and Özge Ozoner and Ebru Emekli Alturfan and Ülkü Noyan. “Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis.” European Journal of Biology, vol. 78, no. 2, 2019, pp. 63-68. [Database Container], https://doi.org/10.26650/EurJBiol.2019.0002


Vancouver

Oktay S, Ozoner Ö, Emekli Alturfan E, Noyan Ü. Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis. European Journal of Biology [Internet]. 26 Apr. 2024 [cited 26 Apr. 2024];78(2):63-68. Available from: https://doi.org/10.26650/EurJBiol.2019.0002 doi: 10.26650/EurJBiol.2019.0002


ISNAD

Oktay, Sehkar - Ozoner, Özge - Emekli Alturfan, Ebru - Noyan, Ülkü. “Determination of Oxidative Stress Parameters and Tissue Factor Activity in the Saliva of Patients with Periodontitis”. European Journal of Biology 78/2 (Apr. 2024): 63-68. https://doi.org/10.26650/EurJBiol.2019.0002



TIMELINE


Submitted03.04.2019
Accepted24.05.2019
Published Online06.12.2019

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