Advances in Cancer Immunotherapy and Stem Cell Research

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DOI :10.26650/B/LS17LS30.2025.038.014   IUP :10.26650/B/LS17LS30.2025.038.014    Tam Metin (PDF)

Embryonic Stem Cells Derivatives: Immunology and Therapeutic Benefits

Sibel Bulgurcuoğlu Kuran, Bilge Şadan Özsait Selçuk

Human embryonic stem cells (hESCs) have the capability to develop into various cell types including adult cells. This characteristic of hESCs has been very attractive to researchers due to their potential applications in regenerative medicine and therapeutics such as stem cell (SC) transplantation. On the other hand, the immunologic properties and the risk of teratoma formation after transplantation have been the major challenges in treatment. To overcome these challenges, several approaches were developed such as forming hESC derivates or establishing hESC banks comprised of a vast diversity of major histocompatibility antigen-presenting cells. Although the tremendous potential of hESCs has been tempting, the use of adult stem cells in therapeutic approaches has exceeded embryonic cells. In this review, first, we have briefly summarized the preimplantation embryo development, the isolation of hESCs, and the immunologic properties of these cells, and then presented different examples for ESCs derivatives. 


Anahtar Kelimeler: Human embryonic stem cells, human embryonic stem cell derivatives, immunogenicity, stem cell therapy

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