Advances in Cancer Immunotherapy and Stem Cell Research

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DOI :10.26650/B/LS17LS30.2025.038.007   IUP :10.26650/B/LS17LS30.2025.038.007    Tam Metin (PDF)

The Role of CD8+CXCR5+ Follicular Cytotoxic T cell and Their Subsets in B Cell Responses and Diseases

Fatih Akboğa, Fehmi Hindilerden, Günnur Deniz, Metin Yusuf Gelmez

CXCR5 expressing CD8+ T cells called follicular cytotoxic CD8+ T (T𝐹𝐶) cells differ phenotypically and transcriptionally from other CD8+ T cells. T𝐹𝐶 migrates to B cell follicles and eliminates infected or malignant B and follicular helper T (T𝐹𝐻) cells secreting perforin and granzyme. Recent studies showed that there is a subset of T𝐹𝐶 that support antibody responses in B cells by expressing CD40L or ICOS. The studies showed that there is a correlation between the frequency and cytolytic function of T𝐹𝐶 cells and the viral load in chronic infections. T𝐹𝐶 have been reported to infiltrate the tumor and nearby lymph nodes in colorectal cancer patients, and levels of TNF-𝛼, IFN-𝛾, granzyme-B, and T𝐹𝐶 frequency are positively correlated with disease prognosis. The cytotoxic effect of T𝐹𝐶 in CLL has been analyzed, but the CD40L-mediated stimulatory effect of T𝐹𝐶 has not been examined yet. Based on the literature, whether T𝐹𝐶 cells and subsets in CLL patients stimulate malignant B cells and increase proliferation, like the T𝐹𝐻 phenotype, or whether they affect malignant B cell lysis via perforin and granzyme were investigated. It provides information about the functional properties, similarities, and differences of ICOS+ T𝐹𝐶, CD40L+ T𝐹𝐶, and ICOS−CD40L−(Double Negative-DN) T𝐹𝐶 subsets defined. In addition, it has been shown that CD40L+ T𝐹𝐶 have the effect of enhancing IgG responses of B cells. However, ICOS+ T𝐹𝐶 express high amount of perforin and granzyme. Further studies are needed to understand the role of T𝐹𝐶 subset in the pathogenesis of diseases such as B cell malignancy.


Anahtar Kelimeler: Chronic lymphocytic leukemia, CLL, follicular cytotoxic CD8+ T cell, T𝐹𝐶, follicular helper CD4+ T cell, T𝐹𝐻, cytotoxicity

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