Geriatrik Nefroloji

EnglishTürkçe

BÖLÜM


DOI :10.26650/B/CH12CH47.2023.014.32   IUP :10.26650/B/CH12CH47.2023.014.32    Tam Metin (PDF)

Yaşlı Hastalarda Transplantasyon

Ayşe Sinangil, Alaattin Yıldız

Böbrek nakli, yaşlı hastalar da dahil olmak üzere son dönem böbrek hastalığı(SDBY) olan çoğu hastanın uzun dönem sağkalımını ve yaşam kalitesini iyileştirmektedir. Bununla birlikte, önemli komorbiditeleri olan yaşlı hastalar, transplantasyonun faydalarını fark edecek kadar uzun yaşamayabilir. Yine bu faydalar, transplantasyondan birkaç ay veya yıl sonrası gibi posttransplant erken dönemlerde gözlenmeyebilir. Böbrek nakli düşünülen yaşlı hastaların dikkatli bir şekilde değerlendirilmesi; hastalara fayda sağlamayacak invaziv işlemlere maruz bırakmamak ve özellikle kadavra verici nakiller için yıllarca başka bir alıcı adayının uzun bir süre kullanabilecekleri bir böbreği boşa harcamamak adına da önemlidir.



Referanslar

  • 1. https://www.usrds.org/qtr/default.aspx (Accessed on December 05, 2018). google scholar
  • 2. http://srtr.transplant.hrsa.gov/annual_reports/2011/default.aspx (Accessed on May 17, 2013). google scholar
  • 3. Schaeffner ES, Rose C, Gill JS. Access to kidney transplantation among the elderly in the United States: a glasshalffull, not halfempty. Clin J Am Soc Nephrol 2010; 5:2109. google scholar
  • 4. Dusseux E, Albano L, Fafin C, et al. A simple clinic altool toinform the decision-making proces storefer elderly incident dialysis patients for kidney transplant evaluation. Kidney Int 2015; 88:121. google scholar
  • 5. Van Pilsum Rasmussen S, Konel J, Warsame F, et al. Engaging clinician sand patients to assessand improve frailty measurement in adults withendsta gerenal disease. BMC Nephrol 2018; 19:8. google scholar
  • 6. McAdams-DeMarco MA, Daubresse M, Bae S, et al. Dementia, Alzheimer’s Disease, and Mortality after Hemodialysis Initiation. Clin J Am Soc Nephrol 2018; 13:1339. google scholar
  • 7. McAdams-DeMarco MA, Bae S, Chu N, et al. Dementia and Alzheimer’s Disease among Older Kidney Transplant Recipients. J Am Soc Nephrol 2017; 28:1575. google scholar
  • 8. McAdams-DeMarco MA, Ying H, Thomas AG, et al. Frailty, Inflammatory Markers, and Waitlist Mortality Among Patients With End-stage Renal Disease in a Prospective Cohort Study. Transplantation 2018; 102:1740. google scholar
  • 9. Weng FL, Reese PP, Mulgaonkar S, Patel AM. Barriers to living donor kidney transplantation among black or older transplantc and idates. Clin J Am Soc Nephrol 2010; 5:2338. google scholar
  • 10. Gill JS, Gill J, Rose C, et al. The older living kidney donor: Part of the solution to the organ shortage. Transplantation 2006; 82:1662. google scholar
  • 11. Rao PS, Merion RM, Ashby VB, et al. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation 2007; 83:1069. google scholar
  • 12. Schold J, Srinivas TR, Sehgal AR, Meier-Kriesche HU. Half of kidney transplantc and idates whoare older than 60 years now placed on the waiting list will die before receiving a deceased-donortransplant. Clin J AmSocNephrol 2009; 4:1239. google scholar
  • 13. Molnar MZ, Streja E, Kovesdy CP, et al. Age and the associations of living donor and expanded criteria donor kidneys with kidney transplant outcomes. Am J Kidney Dis 2012; 59:841. google scholar
  • 14. Rao PS, Merion RM, Ashby VB, et al. Renal transplantation in elderly patients older than 70 years of age: results from the Scientific Registry of Transplant Recipients. Transplantation 2007; 83:1069. google scholar
  • 15. Giessing M, Fuller TF, Friedersdorff F, et al. Outcomes of transplanting deceased-donor kidneys between elderly donors and recipients. J Am Soc Nephrol 2009; 20:37. google scholar
  • 16. Tan JC, Alfrey EJ, Dafoe DC, et al. Dual-kidney transplantation with organs from expanded criteria donors: a long-termfollow-up. Transplantation 2004; 78:692. google scholar
  • 17. Brifkani Z, Alhamad T, Horwedel T, et al. Inductionavoidance in 2-haplotype-matched white living kidney transplantation [abstract]. Am J Transplant. 2015; 15 (suppl 3). https://atcmeetingabstracts.com/abstract/ induction-avoidance-in-2-haplotype-matched-white-living-kidney-transplantation/. google scholar
  • 18. Gill J, Sampaio M, Gill JS, et al. Induction immunosuppressive therapy in the elderly kidney transplant recipient in the United States. Clin J Am Soc Nephrol 2011; 6:1168. google scholar
  • 19. Hurst FP, Altieri M, Nee R, et al. Pooroutcomes in elderly kidney transplant recipients receiving alemtu-zumab induction. Am J Nephrol 2011; 34:534. google scholar
  • 20. Smits JM, Persijn GG, vanHouwelingen HC, et al. Evaluation of the Eurotransplant Senior Program. Theresults of the first year. Am J Transplant 2002; 2:664. google scholar
  • 21. Meier-Kriesche HU, Friedman G, Jacobs M, et al. Infectious complications in geriatric renal transplant patients: comparison of two immunosuppressive protocols. Transplantation 1999; 68:1496. google scholar
  • 22. Meier-Kriesche HU, Morris JA, Chu AH, et al. Mycophenolate mofetil vsazathioprine in a large population of elderly renal transplant patients. Nephrol Dial Transplant 2004; 19:2864. google scholar
  • 23. Danovitch GM, Gill J, Bunnapradist S. Immunosuppression of the elderly kidney transplant recipient. Transplantation 2007; 84:285. google scholar
  • 24. Tullius SG, Tran H, Guleria I, et al. The combination of donor and recipientage is critical in determining host immunoresponsive nessand renal transplant outcome. Ann Surg 2010; 252:662. google scholar
  • 25. McAdams-DeMarco MA, James N, Salter ML, et al. Trends in kidney transplant outcomes in older adults. J Am Geriatr Soc 2014; 62:2235. google scholar
  • 26. Huang E, Poommipanit N, Sampaio MS, et al. Intermediate-term outcomes associated with kidney transplantation in recipients 80 years and older: an analysis of the OPTN/UNOS database. Transplantation 2010; 90:974. google scholar
  • 27. Molnar MZ, Ravel V, Streja E, et al. Survival of Elderly Adults Undergoing Incident Home Hemodialysis and Kidney Transplantation. J Am Geriatr Soc 2016; 64:2003. google scholar
  • 28. Martins PN, Pratschke J, Pascher A, et al. Age and immune response in organ transplantation. Transplan-tation 2005; 79:127. google scholar
  • 29. Haugen CE, Mountford A, Warsame F, et al. Incidence, Risk Factors, and Sequelae of Post-kidney Transplant Delirium. J Am Soc Nephrol 2018; 29:1752. google scholar
  • 30. The 2010 SRTR report on thestate of transplantation www.ustransplant.org/annual_reports (Accessed on February 12, 2012). google scholar


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.