Mi̇krobi̇yotanın İnsan Sağlığı Üzeri̇ne Etki̇leri̇

EnglishTürkçe

BÖLÜM


DOI :10.26650/B/LS34CH11CH22/2024.011.009   IUP :10.26650/B/LS34CH11CH22/2024.011.009    Tam Metin (PDF)

Doğal Mineralli Suların Bağırsak İnflamasyonu ve Bağırsak Mukozası ile İli̇şkili̇ Mi̇krobi̇yota Üzeri̇ne Faydalı Etki̇leri̇

Sevinç Baba

Doğal mineralli sular mikrobiyolojik açıdan sağlıklı sular olarak tanımlanmıştır. Doğal kaynaktan çıkan sular steril olmayıp çeşitli mikroorganizmaları barındırmaktadır. Farklı maden sularının ana parametrelerin analizine dayalı olarak sınıflandırılması için fiziksel ve kimyasal özellikleri kullanılmaktadır. Mineral bileşimi, maden suların; bikarbonatlı, sülfatlı, klorürlü, magnezyumlu, florürlü, kalsiyumlu, demirli ve sodyumlu maden suları olarak sınıflanırılmasını sağlamaktadır. Bu minerallerin insan vücudunda farklı birçok yararlı etkisi bulunmaktadır. Mineral eksikliklerinin gidermenin yanı sıra insan vücudunda farklı biyolojik işlevlerle olumlu etki oluşturmaktadır. Yapılan çalışmalarda şişelenmiş maden sularında mikrobiyolojik risk bildirilmemiştir. Doğal su kaynağında ve pazarlaması sırasında Avrupa Birliği Mevzuatına göre mikrobiyolojik olarak taşıması gereken bazı özellikler bulunmaktadır. Maden su kaynaklarında bakteri sayısı düşük olsa da çok çeşitli mikroorganizmaların (Pseudomonas, Acinetobacter, Stenotrophomonas, Alcaligenes, Comamonas, Acidovorax, Paucimonas, Brevundimonas, Cytophaga, Flavobacterium, Flexibacter, Arthrobacter ve Corynebacterium) varlığı bildirilmiştir. Doğal mineralli suların sindirim sistemi üzerinde yararlı etkileri olduğu ve anti-inflamatuvar etki gösterdiği bilinmektedir. Segmentli filamentöz bakterileri arttırarak bağırsak mukozasıyla ilişkili dengeli bir mikrobiyota oluşumuna katkı sağlamakta ve antimikrobiyal etki oluşturmaktadır. Sonuç olarak, minerallerin bağırsak mikrobiyotası üzerinde etkilerinin olabileceği çeşitli çalışmalarla gösterilmiş, ancak bu konuda daha fazla araştırmaya ihtiyaç duyulmaktadır.


Anahtar Kelimeler: Doğal mineralli su, bağırsak inflamasyonu, mikrobiyota, antimikrobiyal ve antiinflamatuvar etki
DOI :10.26650/B/LS34CH11CH22/2024.011.009   IUP :10.26650/B/LS34CH11CH22/2024.011.009    Tam Metin (PDF)

Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and The Mucosa-Associated Microbiota

Sevinç Baba

Natural mineral waters are defined as microbiologically healthy waters. The waters coming out of the natural source are not sterile and contain various microorganisms. Physical and chemical properties are used to classify different mineral waters based on analysis of main parameters. The mineral composition enables the mineral waters to be classified as bicarbonate, sulfate, chloride, magnesium, fluoridated, calcium, ferrous and sodium mineral waters. These minerals have many beneficial effects on the human body. In addition to eliminating mineral deficiencies, it has a positive effect on the human body with different biological functions. No microbiological risk was reported in bottled mineral waters in the studies. According to the European Union Legislation, there are some microbiological features that must be carried in the natural water source and during its marketing. Although the number of bacteria is low in mineral water sources, the presence of a wide variety of microorganisms (Pseudomonas, Acinetobacter, Stenotrophomonas, Alcaligenes, Comamonas, Acidovorax, Paucimonas, Brevundimonas, Cytophaga, Flavobacterium, Flexibacter, Arthrobacter and Corynebacterium) have been reported. It is known that natural mineral waters have beneficial effects on the digestive system and have an anti-inflammatory effect. By increasing segmented filamentous bacteria, it contributes to the formation of a balanced microbiota associated with the intestinal mucosa and creates an antimicrobial effect.


Anahtar Kelimeler: Natural mineral water, intestinal inflammation, microbiota, antimicrobial and anti-inflammatory effect

Referanslar

  • Akiyama, H., Yamasaki, O., Tada, J., Kubota, K., & Arata, J. (2000). Antimicrobial effects of acidic hot-spring water on Staphylococcus aureus strains isolated from atopic dermatitis patients. J Dermatol Sci, 24(2), 112118. doi:10.1016/s0923-1811(00)00091-8 google scholar
  • Ananthakrishnan, A. N. (2015). Environmental risk factors for inflammatory bowel diseases: a review. Dig Dis Sci, 60(2), 290-298. doi:10.1007/s10620-014-3350-9 google scholar
  • Bankir, L., Perucca, J., Norsk, P., Bouby, N., & Damgaard, M. (2017). Relationship between Sodium Intake and Water Intake: The False and the True. Ann Nutr Metab, 70 Suppl 1, 51-61. doi:10.1159/000463831 google scholar
  • Barnich, N., Rodrigues, M., Sauvanet, P., Chevarin, C., Denis, S., Le Goff, O., . . . Alric, M. (2021). Beneficial Effects of Natural Mineral Waters on Intestinal Inflammation and the Mucosa-Associated Microbiota. In-ternational Journal of Molecular Sciences, 22(9). doi:ARTN 433610.3390/ijms22094336 google scholar
  • Bielik, V., & Kolisek, M. (2021). Bioaccessibility and Bioavailability of Minerals in Relation to a Healthy Gut Microbiome. International Journal of Molecular Sciences, 22(13). doi:10.3390/ijms22136803 google scholar
  • Bothe, G., Coh, A., & Auinger, A. (2017). Efficacy and safety of a natural mineral water rich in magnesium and sulphate for bowel function: a double-blind, randomized, placebo-controlled study. Eur J Nutr, 56(2), 491-499. doi:10.1007/s00394-015-1094-8 google scholar
  • Casanovas-Massana, A., & Blanch, A. R. (2012). Diversity of the heterotrophic microbial populations for distinguishing natural mineral waters. International Journal of Food Microbiology, 153(1-2), 38-44. do-i:10.1016/j.ijfoodmicro.2011.10.012 google scholar
  • Casas, C., Ribet, V., Alvarez-Georges, S., Sibaud, V., Guerrero, D., Schmitt, A. M., & Redoules, D. (2011). Modulation of Interleukin-8 and staphylococcal flora by Avene hydrotherapy in patients suffering from chronic inflammatory dermatoses. J Eur Acad Dermatol Venereol, 25 Suppl 1, 19-23. doi:10.1111/j.1468-3083.2010.03898.x google scholar
  • Celis, A. I., & Relman, D. A. (2020). Competitors versus Collaborators: Micronutrient Processing by Pat-hogenic and Commensal Human-Associated Gut Bacteria. Mol Cell, 78(4), 570-576. doi:10.1016/j.mol-cel.2020.03.032 google scholar
  • Chaplin, A., Parra, P., Laraichi, S., Serra, F., & Palou, A. (2016). Calcium supplementation modulates gut microbiota in a prebiotic manner in dietary obese mice. Mol Nutr Food Res, 60(2), 468-480. doi:10.1002/ mnfr.201500480 google scholar
  • Constante, M., Fragoso, G., Lupien-Meilleur, J., Calve, A., & Santos, M. M. (2017). Iron Supplements Modulate Colon Microbiota Composition and Potentiate the Protective Effects of Probiotics in Dextran Sodium Sulfa-te-induced Colitis. Inflamm Bowel Dis, 23(5), 753-766. doi:10.1097/MIB.0000000000001089 google scholar
  • Directive 2009/54/EC of the European Parliament and of the Council of 18 June 2009 on the exploitation and marketing of natural mineral waters (Recast) (Text with EEA relevance). 27 December 2022). Retrieved from https://eur-lex.europa.eu/legal-content/EN/ALL/?uri=CELEX%3A32009L0054 google scholar
  • Dostal, A., Baumgartner, J., Riesen, N., Chassard, C., Smuts, C. M., Zimmermann, M. B., & Lacroix, C. (2014). Effects of iron supplementation on dominant bacterial groups in the gut, faecal SCFA and gut inflammation: a randomised, placebo-controlled intervention trial in South African children. Br J Nutr, 112(4), 547-556. doi:10.1017/S0007114514001160 google scholar
  • Ericsson, A. C., Hagan, C. E., Davis, D. J., & Franklin, C. L. (2014). Segmented filamentous bacteria: commen-sal microbes with potential effects on research. Comp Med, 64(2), 90-98. Retrieved from https://www.ncbi. nlm.nih.gov/pubmed/24674582 google scholar
  • Gentile, C. L., & Weir, T. L. (2018). The gut microbiota at the intersection of diet and human health. Science, 362(6416), 776-780. doi:10.1126/science.aau5812 google scholar
  • Hugot, J. P., Chamaillard, M., Zouali, H., Lesage, S., Cezard, J. P., Belaiche, J., . . . Thomas, G. (2001). As-sociation of NOD2 leucine-rich repeat variants with susceptibility to Crohn’s disease. Nature, 411(6837), 599-603. doi:10.1038/35079107 google scholar
  • Ivanov, II, Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., . . . Littman, D. R. (2009). Indu-ction of intestinal Th17 cells by segmented filamentous bacteria. Cell, 139(3), 485-498. doi:10.1016/j. cell.2009.09.033 google scholar
  • Kaplan, G. G. (2015). The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol, 12(12), 720-727. doi:10.1038/nrgastro.2015.150 google scholar
  • Khan, I., Ullah, N., Zha, L., Bai, Y., Khan, A., Zhao, T., . . . Zhang, C. (2019). Alteration of Gut Microbiota in Inflammatory Bowel Disease (IBD): Cause or Consequence? IBD Treatment Targeting the Gut Microbiome. Pathogens, 8(3). doi:10.3390/pathogens8030126 google scholar
  • Knights, D., Silverberg, M. S., Weersma, R. K., Gevers, D., Dijkstra, G., Huang, H., . . . Xavier, R. J. (2014). Complex host genetics influence the microbiome in inflammatory bowel disease. Genome Med, 6(12), 107. doi:10.1186/s13073-014-0107-1 google scholar
  • Kortman, G. A., Mulder, M. L., Richters, T. J., Shanmugam, N. K., Trebicka, E., Boekhorst, J., . . . Tjalsma, H. (2015). Low dietary iron intake restrains the intestinal inflammatory response and pathology of enteric infection by food-borne bacterial pathogens. Eur J Immunol, 45(9), 2553-2567. doi:10.1002/eji.201545642 google scholar
  • Leclerc, H., & Moreau, A. (2002). Microbiological safety of natural mineral water. FEMS Microbiol Rev, 26(2), 207-222. doi:10.1111/j.1574-6976.2002.tb00611.x google scholar
  • Lee, D., & Hong, J. H. (2020). The Fundamental Role of Bicarbonate Transporters and Associated Carbonic An-hydrase Enzymes in Maintaining Ion and pH Homeostasis in Non-Secretory Organs. International Journal of Molecular Sciences, 21(1). doi:10.3390/ijms21010339 google scholar
  • Lewis, J. D., Chen, E. Z., Baldassano, R. N., Otley, A. R., Griffiths, A. M., Lee, D., . . . Bushman, F. D. (2015). Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn’s Disease. Cell Host Microbe, 18(4), 489-500. doi:10.1016/j.chom.2015.09.008 google scholar
  • Liu, L., Zheng, Y., Ruan, H., Li, L., Zhao, L., Zhang, M., . . . He, S. (2022). Drinking natural water unchange-ably is associated with reduced all-cause mortality in elderly people: A longitudinal prospective study from China. Front Public Health, 10, 981782. doi:10.3389/fpubh.2022.981782 google scholar
  • Lloyd-Price, J., Arze, C., Ananthakrishnan, A. N., Schirmer, M., Avila-Pacheco, J., Poon, T. W., . . . Huttenhower, C. (2019). Multi-omics of the gut microbial ecosystem in inflammatory bowel diseases. Nature, 569(7758), 655-662. doi:10.1038/s41586-019-1237-9 google scholar
  • Lopez, C. A., & Skaar, E. P. (2018). The Impact of Dietary Transition Metals on Host-Bacterial Interactions. Cell Host Microbe, 23(6), 737-748. doi:10.1016/j.chom.2018.05.008 google scholar
  • Maraver, F., Vitoria, I., Ferreira-Pego, C., Armijo, F., & Salas-Salvado, J. (2015). Magnesium in tap and bottled mineral water in Spain and its contribution to nutritional recommendations. Nutr Hosp, 31(5), 2297-2312. doi:10.3305/nh.2015.31.5.8589 google scholar
  • Martin, R., Henley, J. B., Sarrazin, P., & Seite, S. (2015). Skin Microbiome in Patients With Psoriasis Before and After Balneotherapy at the Thermal Care Center of La Roche-Posay. J Drugs Dermatol, 14(12), 1400-1405. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/26659932 google scholar
  • Mogna, L., Nicola, S., Pane, M., Lorenzini, P., Strozzi, G., & Mogna, G. (2012). Selenium and zinc internalized by Lactobacillus buchneri Lb26 (DSM 16341) and Bifidobacterium lactis Bb1 (DSM 17850): improved bioavailability using a new biological approach. J Clin Gastroenterol, 46 Suppl, S41-45. doi:10.1097/MCG. 0b013e318268861d google scholar
  • Morgan, X. C., Tickle, T. L., Sokol, H., Gevers, D., Devaney, K. L., Ward, D. V., . . . Huttenhower, C. (2012). Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment. Genome Biol, 13(9), R79. doi:10.1186/gb-2012-13-9-r79 google scholar
  • Narciso, L., Martinelli, A., Torriani, F., Frassanito, P., Bernardini, R., Chiarotti, F., & Marianelli, C. (2022). Natural Mineral Waters and Metabolic Syndrome: Insights From Obese Male and Female C57BL/6 Mice on Caloric Restriction. Front Nutr, 9, 886078. doi:10.3389/fnut.2022.886078 google scholar
  • Ni, J., Wu, G. D., Albenberg, L., & Tomov, V. T. (2017). Gut microbiota and IBD: causation or correlation? Nat Rev Gastroenterol Hepatol, 14(10), 573-584. doi:10.1038/nrgastro.2017.88 google scholar
  • Norman, J. M., Handley, S. A., Baldridge, M. T., Droit, L., Liu, C. Y., Keller, B. C., . . . Virgin, H. W. (2015). Disease-specific alterations in the enteric virome in inflammatory bowel disease. Cell, 160(3), 447-460. doi:10.1016/j.cell.2015.01.002 google scholar
  • Oka, A., & Sartor, R. B. (2020). Microbial-Based and Microbial-Targeted Therapies for Inflammatory Bowel Diseases. Dig Dis Sci, 65(3), 757-788. doi:10.1007/s10620-020-06090-z google scholar
  • Piuri, G., Zocchi, M., Della Porta, M., Ficara, V., Manoni, M., Zuccotti, G. V., . . . Cazzola, R. (2021). Mag-nesium in Obesity, Metabolic Syndrome, and Type 2 Diabetes. Nutrients, 13(2). doi:10.3390/nu13020320 google scholar
  • Quattrini, S., Pampaloni, B., & Brandi, M. L. (2016). Natural mineral waters: chemical characteristics and health effects. Clin Cases Miner Bone Metab, 13(3), 173-180. doi:10.11138/ccmbm/2016.13.3.173 google scholar
  • Rocca, G., Dioni, F., Rocca, N., Oliveri, F., Brunetto, M. R., & Bonino, F. (2007). Thermal care of functional dyspepsia based on bicarbonate-sulphate-calcium water: a sequential clinical trial. Evid Based Complement Alternat Med, 4(3), 381-391. doi:10.1093/ecam/nel100 google scholar
  • Said, H., & Kaunitz, J. D. (2016). Gastrointestinal defense mechanisms. Curr Opin Gastroenterol, 32(6), 461466. doi:10.1097/MOG.0000000000000316 google scholar
  • Sauer, A. K., & Grabrucker, A. M. (2019). Zinc Deficiency During Pregnancy Leads to Altered Microbiome and Elevated Inflammatory Markers in Mice. Front Neurosci, 13, 1295. doi:10.3389/fnins.2019.01295 google scholar
  • Schnupf, P., Gaboriau-Routhiau, V., Sansonetti, P. J., & Cerf-Bensussan, N. (2017). Segmented filamentous bacteria, Th17 inducers and helpers in a hostile world. Curr Opin Microbiol, 35, 100-109. doi:10.1016/j. mib.2017.03.004 google scholar
  • Seidler, U. E. (2013). Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniqu-es, transport pathways and regulatory pathways. Curr Opin Pharmacol, 13(6), 900-908. doi:10.1016/j. coph.2013.10.001 google scholar
  • Sharifi-Rad, J., Rodrigues, C. F., Stojanovic-Radic, Z., Dimitrijevic, M., Aleksic, A., Neffe-Skocinska, K., . . . Calina, D. (2020). Probiotics: Versatile Bioactive Components in Promoting Human Health. Medicina (Kaunas), 56(9). doi:10.3390/medicina56090433 google scholar
  • Shi, Z., Zou, J., Zhang, Z., Zhao, X., Noriega, J., Zhang, B., . . . Gewirtz, A. T. (2019). Segmented Filamentous Bacteria Prevent and Cure Rotavirus Infection. Cell, 179(3), 644-658 e613. doi:10.1016/j.cell.2019.09.028 google scholar
  • Totaro, M., Casini, B., Valentini, P., Miccoli, M., Lopalco, P. L., & Baggiani, A. (2018). Assessing natural mineral water microbiology quality in the absence of cultivable pathogen bacteria. J Water Health, 16(3), 425-434. doi:10.2166/wh.2018.183 google scholar
  • Toxqui, L., & Vaquero, M. P. (2016). An Intervention with Mineral Water Decreases Cardiometabolic Risk Biomarkers. A Crossover, Randomised, Controlled Trial with Two Mineral Waters in Moderately Hyper-cholesterolaemic Adults. Nutrients, 8(7). doi:10.3390/nu8070400 google scholar
  • Trapani, V., Petito, V., Di Agostini, A., Arduini, D., Hamersma, W., Pietropaolo, G., . . . Scaldaferri, F. (2018). Dietary Magnesium Alleviates Experimental Murine Colitis Through Upregulation of the Transient Receptor Potential Melastatin 6 Channel. Inflamm Bowel Dis, 24(10), 2198-2210. doi:10.1093/ibd/izy186 google scholar
  • Umesaki, Y., Setoyama, H., Matsumoto, S., Imaoka, A., & Itoh, K. (1999). Differential roles of segmented filamentous bacteria and clostridia in development of the intestinal immune system. Infect Immun, 67(7), 3504-3511. doi:10.1128/IAI.67.7.3504-3511.1999 google scholar
  • Vannucci, L., Fossi, C., Quattrini, S., Guasti, L., Pampaloni, B., Gronchi, G., . . . Brandi, M. L. (2018). Cal-cium Intake in Bone Health: A Focus on Calcium-Rich Mineral Waters. Nutrients, 10(12). doi:10.3390/ nu10121930 google scholar
  • Wallace, J. L., Vong, L., McKnight, W., Dicay, M., & Martin, G. R. (2009). Endogenous and exogenous hydrogen sulfide promotes resolution of colitis in rats. Gastroenterology, 137(2), 569-578, 578 e561. doi:10.1053/j. gastro.2009.04.012 google scholar
  • Whisner, C. M., Martin, B. R., Nakatsu, C. H., McCabe, G. P., McCabe, L. D., Peacock, M., & Weaver, C. M. (2014). Soluble maize fibre affects short-term calcium absorption in adolescent boys and girls: a randomised controlled trial using dual stable isotopic tracers. Br J Nutr, 112(3), 446-456. doi:10.1017/ S0007114514000981 google scholar
  • Zackular, J. P., Moore, J. L., Jordan, A. T., Juttukonda, L. J., Noto, M. J., Nicholson, M. R., . . . Skaar, E. P. (2016). Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nat Med, 22(11), 1330-1334. doi:10.1038/nm.4174 google scholar
  • Zeichner, J., & Seite, S. (2018). From Probiotic to Prebiotic Using Thermal Spring Water. J Drugs Dermatol, 17(6), 657-662. Retrieved from https://www.ncbi.nlm.nih.gov/pubmed/29879253 google scholar


PAYLAŞ




İstanbul Üniversitesi Yayınları, uluslararası yayıncılık standartları ve etiğine uygun olarak, yüksek kalitede bilimsel dergi ve kitapların yayınlanmasıyla giderek artan bilimsel bilginin yayılmasına katkıda bulunmayı amaçlamaktadır. İstanbul Üniversitesi Yayınları açık erişimli, ticari olmayan, bilimsel yayıncılığı takip etmektedir.