Referanslar

• Acosta JC, Gil J. Senescence: A new weapon for cancer therapy. Trends Cell Biol. 2012;22(4):211-219. google scholar
• Coppe JP, Desprez PY, Krtolica A, Campisi J. The senescence-associated secretory phenotype: The dark side of tumor suppres-sion. Annu Rev Pathol. 2010;5:99-118. google scholar
• Childs BG, Durik M, Baker DJ, van Deursen JM. Cellular senes-cence in aging and age-related disease: from mechanisms to ther-apy. Nat Med. 2015;21(12):1424-1435. google scholar
• Yuan J, Ofengeim D. A guide to cell death pathways. Nat Rev Mol Cell Biol. 2024;25(5):379-395. google scholar
• Han J, Zhong CQ, Zhang DW. Programmed necrosis: Backup to and competitor with apoptosis in the immune system. Nat Immunol. 2011;12(12):1143-1149. google scholar
• Sanz AB, Sanchez-Nino MD, Ramos AM, Ortiz A. Regu-lated cell death pathways in kidney disease. Nat Rev Nephrol. 2023;19(5):281-299. google scholar
• Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A. In-flammaging: A new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol. 2018;14(10):576-590. google scholar
• Ferrucci L, Fabbri E. Inflammageing: Chronic inflammation in ageing, cardiovascular disease, and frailty. Nat Rev Cardiol. 2018;15(9):505-522. google scholar
• Hotamisligil GS. Inflammation and metabolic disorders. Nature. 2006;444(7121):860-867. google scholar
• Salminen A, Kaarniranta K, Kauppinen A. Inflammaging: Disturbed interplay between autophagy and inflammasomes. Aging-Us. 2012;4(3):166-175. google scholar
• Esrefoglu M, Kalkan TK, Karatas E, et al. Hepatoprotective actions of melatonin by mainly modulating oxidative status and apoptosis rate in lipopolysaccharide-induced liver damage. Immunopharm Immunot. 2024;46(2):161-171. google scholar
• Lopez-Otm C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013;153(6):1194-1217. google scholar
• Mehdizadeh M, Aguilar M, Thorin E, Ferbeyre G, Nattel S. The role of cellular senescence in cardiac disease: basic biology and clinical relevance. Nat Rev Cardiol. 2022;19(4):250-264. google scholar
• Ishaq A, Tchkonia T, Kirkland JL, Siervo M, Saretzki G. Palmitate induces DNA damage and senescence in human adipocytes in vitro that can be alleviated by oleic acid but not inorganic nitrate. Exp Gerontol. 2022;163:111798. doi:10.1016/j.exger.2022.111798 google scholar
• Lagnado A, Leslie J, Ruchaud-Sparagano MH, et al. Neu-trophils induce paracrine telomere dysfunction and senes-cence in ROS-dependent manner. Embo J. 2021;40(9):e106048. doi:10.15252/embj.2020106048 google scholar
• Palmer AK, Gustafson B, Kirkland JL, Smith U. Cellular senes-cence: At the nexus between ageing and diabetes. Diabetologia. 2019;62(10):1835-1841. google scholar
• Miwa S, Kashyap S, Chini E, von Zglinicki T. Mitochon-drial dysfunction in cell senescence and aging. J Clin Invest. 2022;132(13):e158447. doi:10.1172/JCI158447 google scholar
• Xu M, Pirtskhalava T, Farr JN, et al. Senolytics improve physical function and increase lifespan in old age. Nat Med. 2018;24(8):1246-1256. google scholar
• Acosta JC, Banito A, Wuestefeld T, et al. A complex secretory program orchestrated by the inflammasome controls paracrine senescence. Nat Cell Biol. 2013;15(8):978-990. google scholar
• Franceschi C, Campisi J. Chronic inflammation (inflammag-ing) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci. 2014;69 Suppl 1:S4-S9. doi:10.1093/gerona/glu057 google scholar
• Stahl EC, Delgado ER, Alencastro F, et al. Inflammation and ectopic fat deposition in the aging murine liver is influenced by CCR2. Am J Pathol. 2020;190(2):372-387. google scholar
• Marquez-Exposito L, Tejedor-Santamaria L, Santos-Sanchez L, et al. Acute kidney injury is aggravated in aged mice by the exacerbation of proinflammatory processes. Front Pharmacol. 2021;12:662020. doi:10.3389/fphar.2021.662020 google scholar
• Tower J. Programmed cell death in aging. Ageing Res Rev. 2015;23(Pt A):90-100. google scholar
• Walczak H. TNF and ubiquitin at the crossroads of gene activation, cell death, inflammation, and cancer. Immunol Rev. 2011;244:9-28. google scholar
• Bertheloot D, Latz E, Franklin BS. Necroptosis, pyroptosis and apoptosis:An intricate game of cell death. Cell Mol Immunol. 2021;18(5):1106-1121. google scholar
• Vandenabeele P, Galluzzi L, Vanden Berghe T, Kroemer G. Molecular mechanisms of necroptosis: an ordered cellular ex-plosion. Nat Rev Mol Cell Biol. 2010;11(10):700-714. google scholar
• Newton K, Manning G. Necroptosis and inflammation. Annu Rev Biochem. 2016;85:743-763. google scholar
• Murphy JM, Czabotar PE, Hildebrand JM, et al. The pseudokinase MLKL mediates necroptosis via a molecular switch mechanism. Immunity. 2013;39(3):443-453. google scholar
• Sun L, Wang H, Wang Z, et al. Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase. Cell. 2012;148(1-2):213-227. google scholar
• Silke J. The regulation of TNF signalling: What a tangled web we weave. Curr Opin Immunol. 2011;23(5):620-626. google scholar
• Kanayama A, Seth RB, Sun LJ, et al. TAB2 and TAB3 activate the NF-kB pathway through binding to polyubiquitin chains. Mol Cell. 2004;15(4):535-548. google scholar
• Mohammed S, Thadathil N, Selvarani R, et al. Necroptosis con-tributes to chronic inflammation and fibrosis in aging liver. Aging Cell. 2021;20(12):e13512. doi:10.1111/acel.13512 google scholar

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